6533b823fe1ef96bd127f542

RESEARCH PRODUCT

Pyrocoll, an Antibiotic, Antiparasitic and Antitumor Compound Produced by a Novel Alkaliphilic Streptomyces Strain

Hans-peter FiedlerWinfried BeilWerner E.g. MüllerAnke DieterReto BrunMichael GoodfellowAndreas HammGerhard Bringmann

subject

Spectrophotometry InfraredAntiparasiticmedicine.drug_classMetaboliteAntiprotozoal AgentsMicrobial Sensitivity TestsSecondary metaboliteStreptomycesMass SpectrometryMicrobiologyMicechemistry.chemical_compoundArthrobacterDrug DiscoverymedicineAnimalsHumansPyrrolesNuclear Magnetic Resonance BiomolecularChromatography High Pressure LiquidSoil MicrobiologyAntibacterial agentPharmacologyAntibiotics AntineoplasticbiologyStreptomycetaceaebiology.organism_classificationStreptomyceschemistryFermentationChromatography GelActinomycetalesDrug Screening Assays AntitumorHeLa Cellsmedicine.drug

description

A new secondary metabolite was detected in the culture extract of Streptomyces sp. AK 409 by HPLC-diode-array screening. The metabolite was identified as pyrocoll, which is known to be a constituent of cigarette smoke. Pyrocoll is known as a synthetic compound, but until now had not been isolated as a natural product from a microorganism. The compound showed biological activity against various Arthrobacter strains, filamentous fungi, several pathogenic protozoa, and some human tumor cell lines.

yearjournalcountryeditionlanguage
2003-09-30The Journal of Antibiotics
https://doi.org/10.7164/antibiotics.56.639