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Tīmekļa lietotņu veiktspējas optimizācija AngularJS lietotnēs
2016
Darbā Tīmekļa lietotņu veiktspējas optimizācija AngularJS lietotnēs tiek pētīts klienta puses lietotņu izstrādes ietvars AngularJS un tā tipiskākie veiktspējas trūkumi un izstrādātāju kļūdas, kā arī veidi kā risināt šīs kļūdas un uzlabot lietotņu veiktspēju. Pētījums balstās uz informāciju, kas atrodama paša ietvara oficiālajā dokumentācijā un pieredzējušu AngularJS lietotāju viedokļiem par šī ietvara potenciālajām problēmām un to risinājumiem. Pārsvarā tiek aplūkoti veidi kā veidot lietotnes izvairoties no AngularJS problemātiskajām konstrukcijām.
L’imaginaire trichologique dans l’œuvre de Julien Green (1924-1930)
2015
I capelli e, per estensione, la pelosità occupano generalmente un ruolo importante nel campo dell'antropologia e dell'etnologia, dove sono oggetto di numerosi studi. Trovano anche un posto significativo nella categoria della descrizione e più specificamente in quella del ritratto. Nell’opera letteraria di Julien Green le notazioni sui capelli e, più in generale, sul sistema tricologico dei personaggi sono numerose e partecipano pienamente alla costituzione dell’ "effet-personnage". Questo articolo si propone di esaminare dettagliatamnte il rapporto che intrattengono nell'immaginario dell'autore attraverso una lettura dei suoi primi racconti (Christine, Le Voyageur sur la terre, Léviathan (L…
Pieśni chóru pod skreśleniem w "Zawiszy Czarnym" Juliusza Słowackiego
2019
The manuscript of the drama about Zawisza Czarny (unreleased during the poet’s life) is divided in editions and critical analyzes into two, three or four editorials in which individual scenes sometimes obtained more than one study. There are significant differences between the various editorial regarding the construction of the presented world, which is evidenced by the condition and function of the choir, present only in two out of four editors (C and D) and in different studies of one episode (D, C2 and C1). The choir (Chorus) once remains merely a retinue of the powerful spirit of the mythical Wanda (D), other times it shortens its distance from the characters and may even join their dia…
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles.
2008
Spermatogonial stem cells (SSCs) isolated from the adult mouse testis and cultured have been shown to respond to culture conditions and become pluripotent, so called multipotent adult germline stem cells (maGSCs). microRNAs (miRNAs) belonging to the 290 and 302 miRNA clusters have been previously classified as embryonic stem cell (ESC) specific. Here, we show that these miRNAs generally characterize pluripotent cells. They are expressed not only in ESCs but also in maGSCs as well as in the F9 embryonic carcinoma cell (ECC) line. In addition, we tested the time-dependent influence of different factors that promote loss of pluripotency on levels of these miRNAs in all three pluripotent cell t…
Characterization of disease-specific cellular abundance profiles of chronic inflammatory skin conditions from deconvolution of biopsy samples
2019
Background Psoriasis and atopic dermatitis are two inflammatory skin diseases with a high prevalence and a significant burden on the patients. Underlying molecular mechanisms include chronic inflammation and abnormal proliferation. However, the cell types contributing to these molecular mechanisms are much less understood. Recently, deconvolution methodologies have allowed the digital quantification of cell types in bulk tissue based on mRNA expression data from biopsies. Using these methods to study the cellular composition of the skin enables the rapid enumeration of multiple cell types, providing insight into the numerical changes of cell types associated with chronic inflammatory skin c…
Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
2008
Summary Telomerase confers limitless proliferative potential to most human cells through its ability to elongate telomeres, the natural ends of chromosomes, which otherwise would undergo progressive attrition and eventually compromise cell viability. However, the role of telomerase in organismal aging has remained unaddressed, in part because of the cancer-promoting activity of telomerase. To circumvent this problem, we have constitutively expressed telomerase reverse transcriptase (TERT), one of the components of telomerase, in mice engineered to be cancer resistant by means of enhanced expression of the tumor suppressors p53, p16, and p19ARF. In this context, TERT overexpression improves …
Melittin Modulates Keratinocyte Function through P2 Receptor-dependent ADAM Activation
2012
Melittin, the major component of the bee venom, is an amphipathic, cationic peptide with a wide spectrum of biological properties that is being considered as an anti-inflammatory and anti-cancer agent. It modulates multiple cellular functions but the underlying mechanisms are not clearly understood. Here, we report that melittin activates disintegrin-like metalloproteases (ADAMs) and that downstream events likely contribute to the biological effects evoked by the peptide. Melittin stimulated the proteolysis of ADAM10 and ADAM17 substrates in human neutrophil granulocytes, endothelial cells and murine fibroblasts. In human HaCaT keratinocytes, melittin induced shedding of the adhesion molecu…
Keratinocytes Determine Th1 Immunity during Early Experimental Leishmaniasis
2010
Experimental leishmaniasis is an excellent model system for analyzing Th1/Th2 differentiation. Resistance to Leishmania (L.) major depends on the development of a L. major specific Th1 response, while Th2 differentiation results in susceptibility. There is growing evidence that the microenvironment of the early affected tissue delivers the initial triggers for Th-cell differentiation. To analyze this we studied differential gene expression in infected skin of resistant and susceptible mice 16h after parasite inoculation. Employing microarray technology, bioinformatics, laser-microdissection and in-situ-hybridization we found that the epidermis was the major source of immunomodulatory mediat…
cFLIPL Inhibits Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated NF-κB Activation at the Death-inducing Signaling Complex in Human Ke…
2004
Human keratinocytes undergo apoptosis following treatment with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via surface-expressed TRAIL receptors 1 and 2. In addition, TRAIL triggers nonapoptotic signaling pathways including activation of the transcription factor NF-kappaB, in particular when TRAIL-induced apoptosis is blocked. The intracellular protein cFLIP(L) interferes with TRAIL-induced apoptosis at the death-inducing signaling complex (DISC) in many cell types. To study the role of cFLIP(L) in TRAIL signaling, we established stable HaCaT keratinocyte cell lines expressing varying levels of cFLIP(L). Functional analysis revealed that relative cFLIP(L) levels correlat…
Shuttling of the autoantigen La between nucleus and cell surface after uv irradiation of human keratinocytes.
1990
During the past years we have established that the nuclear autoantigen La shuttles between the nucleus and the cytoplasm in tumor cells after inhibition of transcription or virus infection. We reinvestigated this shuttling using primary human keratinocytes from both healthy donors and patients with xeroderma pigmentosum. Ultraviolet irradiation resulted in both an inhibition of transcription and a translocation of La protein from the nucleus to the cytoplasm. After a prolonged inhibition of transcription La protein relocated into the nucleus and assembled with nuclear storage regions. The uv-induced shuttling included a translocation to the cell surface, where La protein colocalized with ep…