Search results for "script"

<strong>Predicting Proteasome Inhibition using Atomic Weighted Vector and Machine Learning</strong>

2018

Ubiquitin/Proteasome System (UPS) is a highly regulated mechanism of intracellular protein degradation and turnover. Through the concerted actions of a series of enzymes, proteins are marked for proteasomal degradation by being linked to the polypeptide co-factor, ubiquitin. The UPS participates in a wide array of biological functions such as antigen presentation, regulation of gene transcription and the cell cycle, and activation of NF-κB. Some researchers have applied QSAR method and machine learning in the study of proteasome inhibition (EC50(µmol/L)), such as: the analysis of proteasome inhibition prediction, in the prediction of multi-target inhibitors of UPP and in the prediction of p…

Implications of the restoration of chiral symmetry in bag model building

1985

We analyze via a bag model description of hadron structure the consequences of having two fundamental scales in QCD, one associated with confinement and the other with chiral-symmetry restration. The main effect is that the exterior pion field becomes weaker and, therefore, we are able to reproduce the axial-vector coupling constant.

QCD matching conditions at thresholds

1993

The use of MS-like renormalization schemes in QCD requires an implementation of nontrivial matching conditions across thresholds, a fact often overlooked in the literature. We shortly review the use of these matching conditions in QCD and check explicitly that the prediction for $\alpha_s(M_Z)$, obtained by running the strong coupling constant from the $M_\tau$ scale, does not substantially depend on the exact value of the matching point chosen in crossing the $b$-quark threshold when the appropriate matching conditions are taken into account.

Consistent measurements of alpha(s) from precise oriented event shape distributions

2000

An updated analysis using about 1.5 million events recorded at $\sqrt{s} = M_Z$ with the DELPHI detector in 1994 is presented. Eighteen infrared and collinear safe event shape observables are measured as a function of the polar angle of the thrust axis. The data are compared to theoretical calculations in ${\cal O} (\alpha_s^2)$ including the event orientation. A combined fit of $\alpha_s$ and of the renormalization scale $x_{\mu}$ in $\cal O(\alpha_s^2$) yields an excellent description of the high statistics data. The weighted average from 18 observables including quark mass effects and correlations is $\alpha_s(M_Z^2) = 0.1174 \pm 0.0026$. The final result, derived from the jet cone energ…

3D modul for syntetisk kalkulator

2006

Masteroppgave i informasjons- og kommunikasjonsteknologi 2006 - Høgskolen i Agder, Grimstad ActionScript er et språk som har blitt benyttet mer og mer de senere årene og er en del av verktøyet Flash. Dette er et design verktøy som har gode metoder for animasjoner i 2D og genererer små filer som gjør det svært egnet for internett. Denne rapporten ser på mulighetene for å generere, håndtere og visualisere tredimensjonale objekter i Flash ved bruk av ActionScript. Det blir diskutert roteringsmatriser opp mot Quaternion rotasjon og isometrisk projeksjon opp mot perspektivisk projeksjon i forhold til 3D objekter. Rapporten tar for seg ulike kurver og flater og hvilke begrensninger ActionScript h…

Interacting With Human Simulations: A Prototype Application

2019

The process of interacting and executing agent-based simulations of human phenomena is complex and difficult to follow for lay people. This is due to 1) limited access to computing power, 2) difficulty in writing analytics scripts and 3) the size and complexity of the simulation space. Consequently, agent-based simulations are normally used once to answer a limited set of questions instead of exploring all the potential paths that the model offers. Here, we describe an approach for developing user experiences that automate the analytic process and rely on interactive visualizations and life histories of societies and agents. This approach helps the user visualize simulation results, pin-poi…

Non-coding RNAs at the Eukaryotic rDNA Locus: RNA–DNA Hybrids and Beyond

2019

The human ribosomal DNA (rDNA) locus encodes a variety of long non-coding RNAs (lncRNAs). Among them, the canonical ribosomal RNAs that are the catalytic components of the ribosomes, as well as regulatory lncRNAs including promoter-associated RNAs (pRNA), stress-induced promoter and pre-rRNA antisense RNAs (PAPAS), and different intergenic spacer derived lncRNA species (IGSRNA). In addition, externally encoded lncRNAs are imported into the nucleolus, which orchestrate the complex regulation of the nucleolar state in normal and stress conditions via a plethora of molecular mechanisms. This review focuses on the triplex and R-loop formation aspects of lncRNAs at the rDNA locus in yeast and hu…

El perfil de aplicación de RDA para monografías antiguas de la Biblioteca Nacional de España

2023

La Biblioteca Nacional de España ha trabajado activamente en la adaptación de RDA a la descripción del libro antiguo desde el año 2015, hasta poder afrontar finalmente desde el año 2020 el paso definitivo: la redacción del perfil de aplicación de RDA para monografías antiguas de la BNE. Este trabajo ha permitido identificar los principales retos de esta aplicación, así como aprovechar las oportunidades que ofrece al catalogador de libro antiguo. Entre los aspectos más novedosos se cuentan instrucciones destinadas a la transcripción, al uso de las menciones de publicación, distribución y fabricación, así como al desarrollo de las relaciones a nivel de manifestación que permitirán por primera…

THE PURPOSING OF NEW COMPOUNDS OR THE RE-PURPOSING OF OLD DRUGS BY MEANS OF MULTIVARIATE ANATYSIS ON MOLECULAR DESCRIPTORS

2010

Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids

2005

Dietary vegetable oils and fish oils rich in PUFA (polyunsaturated fatty acids) exert hypocholesterolaemic and hypotriglyceridaemic effects in rodents. The plasma cholesterol-lowering properties of PUFA are due partly to a diminution of cholesterol synthesis and of the activity of the rate-limiting enzyme HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase). To better understand the mechanisms involved, we examined how tuna fish oil and individual n−3 and n−6 PUFA affect the expression of hepatic FPP synthase (farnesyl diphosphate synthase), a SREBP (sterol regulatory element-binding protein) target enzyme that is subject to negative-feedback regulation by sterols, in co-ordination …