Search results for "script"
showing 10 items of 5143 documents
Ripensare il curricolo a partire dai learning outcomes. Un’indagine esplorativa nel CdS-L19 dell’Università di Catania per sostenere processi di camb…
2021
Il presente contributo descrive l’indagine esplorativa avviata a seguito dell’analisi dei dati emersi dalla sperimentazione TECO-D/ Pedagogia alla quale ha partecipato il CdS L-19 dell’Università di Catania. I risultati della somministrazione dei test agli studenti hanno indotto le Autrici a operare una riflessione sul contributo che le discipline del curricolo della L-19 forniscono al raggiungimento dei contenuti core definiti dalla sperimentazione. Grazie a uno strumento di rilevazione appositamente creato, è stato chiesto a tutti i docenti del CdS di operare una riflessione sul contributo che l ’ i n s e g n a m e n t o p r o f e s s a t o o f f r e a l raggiungimento degli obiettivi for…
Defective Postnatal Neurogenesis and Disorganization of the Rostral Migratory Stream in Absence of theVax1Homeobox Gene
2004
The subventricular zone (SVZ) is one of the sources of adult neural stem cells (ANSCs) in the mouse brain. Precursor cells proliferate in the SVZ and migrate through the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate into granule and periglomerular cells. Few transcription factors are known to be responsible for regulating NSC proliferation, migration, and differentiation processes; even fewer have been found to be responsible for the organization of the SVZ and RMS. For this reason, we studied the ventral anterior homeobox (Vax1) gene in NSC proliferation and in SVZ organization. We found thatVax1is strongly expressed in the SVZ and in the RMS and that,…
Glutathione regulates telomerase activity in 3T3 fibroblasts.
2004
Changes in telomerase activity have been associated either with cancer, when activity is increased, or with cell cycle arrest when it is decreased. We report that glutathione, a physiological antioxidant present at high intracellular concentrations, regulates telomerase activity in cells in culture. Telomerase activity increases in 3T3 fibroblasts before exponential cell growth. The peak of telomerase activity takes place 24 h after plating and coincides with the maximum levels of glutathione in the cells. When cells are treated with buthionine sulfoximine, which decreases glutathione levels in cells, telomerase activity decreases by 60%, and cell growth is delayed. Glutathione depletion in…
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
2013
Journal article TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10!-7), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10!-8) and BRCA1 mutation carrier (P = 1.1 × 10!-5) breast cancers and altered promot…
A homolog of the putative tumor suppressor QM in the sponge Suberites domuncula: downregulation during the transition from immortal to mortal (apopto…
1999
Abstract The activation of components of the transcription factors such as AP-1 or c-jun is essential for a physiological response of metazoan cells during aging. The activity of such proto-oncoproteins is under enzymatic control. The function of c-jun is additionally modulated by the QM protein. Here, we studied the expression of the gene, encoding the QM-like protein in the sponge Suberites domuncula . These animals contain high levels of telomerase in their somatic cells. To understand the switch from telomerase-positive immortal cells to telomerase-negative mortal cells which undergo apoptosis, the expression of the QM-like gene was measured in this system. The cDNA, termed QMSD , encod…
Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence.
2020
Telomeres have the ability to adopt a lariat conformation and hence, engage in long and short distance intra-chromosome interactions. Budding yeast telomeres were proposed to fold back into subtelomeric regions, but a robust assay to quantitatively characterize this structure has been lacking. Therefore, it is not well understood how the interactions between telomeres and non-telomeric regions are established and regulated. We employ a telomere chromosome conformation capture (Telo-3C) approach to directly analyze telomere folding and its maintenance in S. cerevisiae. We identify the histone modifiers Sir2, Sin3 and Set2 as critical regulators for telomere folding, which suggests that a dis…
Short telomeres drive pessimistic judgement bias in zebrafish.
2021
The role of telomerase reverse transcriptase has been widely investigated in the contexts of ageing and age-related diseases. Interestingly, decreased telomerase activities (and accelerated telomere shortening) have also been reported in patients with emotion-related disorders, opening the possibility for subjective appraisal of stressful stimuli playing a key role in stress-driven telomere shortening. In fact, patients showing a pessimistic judgement bias have shorter telomeres. However, in humans the evidence for this is correlational and the causal directionality between pessimism and telomere shortening has not been established experimentally yet. We have developed and validated a judg…
Temperature-related effects on respiratory medical prescriptions in Spain
2021
Background The increased risk of mortality during periods of high and low temperatures has been well established. However, most of the studies used daily counts of deaths or hospitalisations as health outcomes, although they are the ones at the top of the health impact pyramid reflecting only a limited proportion of patients with the most severe cases. Objectives This study evaluates the relationship between short-term exposure to the daily mean temperature and medication prescribed for the respiratory system in five Spanish cities. Methods We fitted time series regression models to cause-specific medical prescriptions, including different respiratory subgroups and age groups. We included a…
The cognitive shift in terminology and specialized translation
2009
Este artículo propone un análisis crítico y una visión global de las teorías terminológicas con especial atención a la traducción científica y técnica. El estudio de los tecnolectos está sometido en la actualidad a un cambio hacia el cognitivismo, que a su vez conduce a un énfasis mucho mayor tanto en el significado como en las estructuras conceptuales que subyacen en los textos y en la lengua en general. La terminología parece estar pasando del prescriptivismo al descriptivismo, con un interés creciente por enfocar el estudio de las unidades de los tecnolectos desde una perspectiva social, lingüística y cognitiva. En esta misma línea, comienzan a oírse nuevas voces que ofrecen perspectivas…
Reflection Assignment as a Tool to Support Students’ Metacognitive Awareness in the Context of Computer-Supported Collaborative Learning
2021
The present study explores the potential of a reflection assignment as a tool for supporting master’s degree students’ metacognitive skills in the context of computer-supported collaborative learning (CSCL). The research question (RQ) is formulated as follows: How does a regularly submitted reflection assignment support the development of students’ individual metacognitive awareness in the context of CSCL? The empirical data is a text corpus (7878 words) extracted from individual students’ (N = 13) reflection assignments (N = 65) submitted during one semester. Qualitative content analysis was employed to analyze the data. The results demonstrate that by the end of the course, the students s…