Search results for "script"

A statistical model for magnitudes and angles of wavelet frame coefficients and its application to texture retrieval

2014

Abstract This paper presents a texture descriptor based on wavelet frame transforms. At each position in the image, and for each resolution level, we consider both vertical and horizontal wavelet detail coefficients as the components of a bivariate random vector. The magnitudes and angles of these vectors are computed. At each level the empirical histogram of magnitudes is modeled by a Generalized Gamma distribution, and the empirical histogram of angles is modeled by a different version of the von Mises distribution that accounts for histograms with 2 modes. Each texture is characterized by few parameters. A new distance is presented (based on the Kullback–Leibler divergence) that allows g…

Spectrum of novel mutations found in Waardenburg syndrome types 1 and 2: implications for molecular genetic diagnostics

2013

Objectives Till date, mutations in the genes PAX3 and MITF have been described in Waardenburg syndrome (WS), which is clinically characterised by congenital hearing loss and pigmentation anomalies. Our study intended to determine the frequency of mutations and deletions in these genes, to assess the clinical phenotype in detail and to identify rational priorities for molecular genetic diagnostics procedures. Design Prospective analysis. Patients 19 Caucasian patients with typical features of WS underwent stepwise investigation of PAX3 and MITF . When point mutations and small insertions/deletions were excluded by direct sequencing, copy number analysis by multiplex ligation-dependent probe …

Multifocal TMS for temporo-spatial description of cortico-cortical connectivity patterns

2016

Pathogenesis of inflammatory bowel disease: transcription factors in the spotlight.

1998

See article on page 477 Dysregulated cytokine production by mucosal lymphocytes and macrophages has been implicated in the pathogenesis of both Crohn’s disease and ulcerative colitis, the two major forms of human inflammatory bowel disease (IBD).1 Over the past few years, various murine models of chronic intestinal inflammation resembling IBD have been discovered which have provided important clues as to the nature of this dysregulation and to its possible treatment with cytokines.2 Thus, in studies of several of the models most closely resembling Crohn’s disease it has been shown that production of large amounts of Th1-type cytokines—for example, interferon γ, by T cells is a major and ess…

Reinforcement Efficiency of Cellulose Microfibers for the Tensile Stiffness and Strength of Rigid Low-Density Polyurethane Foams

2020

Rigid low-density closed-cell polyurethane (PU) foams are widely used in both thermal insulation and structural applications. The sustainability of PU foam production can be increased by using bio-based components and fillers that ensure both enhanced mechanical properties and higher renewable material content. Such bio-based foams were produced using polyols derived from rapeseed oil and microcrystalline cellulose (MCC) fibers as filler. The effect of MCC fiber loading of up to 10 wt % on the morphology, tensile stiffness, and strength of foams has been evaluated. For estimation of the mechanical reinforcement efficiency of foams, a model allowing for the partial alignment of filler fibers…

Canine Mesenchymal Stem Cells from visceral and subcutaneuous adipose tissue for cell-based therapy

2012

This study compared some characteristics of canine Adipose tissue-Derived Mesenchymal Stem Cells (cAD-MSCs) from subcutaneous and visceral fat. These findings were directed to obtain high quantity and quality cAD-MSCs for clinical cell-based therapy.

MiR-221 promotes stemness of breast cancer cells by targeting DNMT3b

2016

// Giuseppina Roscigno 1, 2 , Cristina Quintavalle 1, 2 , Elvira Donnarumma 3 , Ilaria Puoti 1 , Angel Diaz-Lagares 4 , Margherita Iaboni 1 , Danilo Fiore 1 , Valentina Russo 1 , Matilde Todaro 5 , Giulia Romano 6 , Renato Thomas 7 , Giuseppina Cortino 7 , Miriam Gaggianesi 5 , Manel Esteller 4 , Carlo M. Croce 6 , Gerolama Condorelli 1, 2 1 Department of Molecular Medicine and Medical Biotechnology, “Federico II” University of Naples, Naples, Italy 2 IEOS-CNR, Naples, Italy 3 IRCCS-SDN, Naples, Italy 4 Epigenetic and Cancer Biology Program (PEBC) IDIBELL, Hospital Duran I Reynals, Barcelona, Spain 5 Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Lab…

Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mous…

2013

The t(8;21) chromosomal translocation activates aberrant expression of the AML1-ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML). Combining a conditional mouse model that closely resembles the slow evolution and the mosaic AE expression pattern of human t(8;21) CBF AML with global transcriptome sequencing, we find that disease progression was characterized by two principal pathogenic mechanisms. Initially, AE expression modified the lineage potential of haematopoietic stem cells (HSCs), resulting in the selective expansion of the myeloid compartment at the expense of normal erythro- and lymphopoiesis. This lineage skewing was foll…

TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells

2015

Metastatic growth in breast cancer (BC) has been proposed as an exclusive property of cancer stem cells (CSCs). However, formal proof of their identity as cells of origin of recurrences at distant sites and the molecular events that may contribute to tumor cell dissemination and metastasis development are yet to be elucidated. In this study, we analyzed a set of patient-derived breast cancer stem cell (BCSC) lines. We found that in vitro BCSCs exhibit a higher chemoresistance and migratory potential when compared with differentiated, nontumorigenic, breast cancer cells (dBCCs). By developing an in vivo metastatic model simulating the disease of patients with early BC, we observed that BCSCs…

Teksta iegūšana no HTML5 canvas elementiem

2016

HTML5 canvas elements un visa tajā atveidotā informācija pēc būtības ir attēls, līdz ar to, no lietojamības viedokļa, grūti pieejams lietotājiem, it īpaši redzes invalīdiem, kuri paļaujas uz ekrāna lasīšanas programmatūru. Darbā pētītas vairākas dažādas metodes HTML5 canvas elementos zīmētās teksta informācijas iegūšanai no lietotāja puses, ļaujot tekstu iezīmēt, kopēt un padarot to pieejamu ekrāna lasīšanas programmatūrai, tādējādi uzlabojot tīmekļa vides lietojamību, it īpaši cilvēkiem ar redzes problēmām. Darba rezultātā veiksmīgi izveidots JavaScript spraudnis, kuru tīmekļa lietotņu izstrādātāji var izmantot, lai bez piepūles zīmētu iezīmējamu, kopējamu un ekrāna lasītājiem pieejamu tek…