Search results for "securin"

showing 6 items of 6 documents

Spatial learning and long-term memory impairments in RasGrf1 KO, Pttg1 KO, and double KO mice

2018

© 2018 The Authors.

0301 basic medicineMaleMemory Long-TermHippocampusSpatial learningBiologyHippocampusBarnes mazememory03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineDiscrimination PsychologicalMemoryAnimalsPttg1Maze LearningChromosome separationOriginal ResearchMice KnockoutPCALong-term memoryras-GRF1spatial learningBrainBarnes mazeMice Inbred C57BLSecurin030104 developmental biologySecurinCervell Localització de funcionsMemory consolidationFemaleSignal transductionBeta cellRasGrf1Neuroscience030217 neurology & neurosurgerySignal Transduction
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PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival.

2017

Background: PTTG1-interacting protein (PTTG1IP) is an oncogenic protein, which participates in metaphase-anaphase transition of the cell cycle through activation of securin (PTTG1). PTTG1IP promotes the shift of securin from the cell cytoplasm to the nucleus, allowing the interaction between separase and securin. PTTG1IP overexpression has been previously observed in malignant disease, e.g. in breast carcinoma. However, the prognostic value of PTTG1IP in breast carcinoma patients has not previously been revealed. Methods: A total of 497 breast carcinoma patients with up to 22-year follow-up were analysed for PTTG1IP and securin immunoexpression. The results were evaluated for correlations w…

0301 basic medicineOncologyCancer ResearchTriple Negative Breast NeoplasmsKaplan-Meier EstimatePBF0302 clinical medicineBreast cancerSurgical oncologyRisk FactorsAged 80 and overrintasyöpäPTTG1 interacting proteinIntracellular Signaling Peptides and ProteinsCell cycleMiddle Agedlcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensPrognosisImmunohistochemistrySecurinsyöpägeenitOncologySecurin030220 oncology & carcinogenesisImmunohistochemistryFemaleSeparaseBreast carcinomaResearch ArticleAdultmedicine.medical_specialtyPTTG1IPBreast Neoplasmslcsh:RC254-282immunohistokemia03 medical and health sciencesBreast cancerInternal medicineGeneticsmedicineBiomarkers TumorHumansAgedbusiness.industryMembrane Proteinsmedicine.disease030104 developmental biologyMultivariate AnalysisCancer researchprognosisproteiinitbusinessBMC cancer
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Separase is a marker for prognosis and mitotic activity in breast cancer

2017

Background: Cancer cell proliferation is a critical feature in classifying and predicting the outcome of breast carcinoma. Separase has a central role in cell cycle progression in unleashing sister-chromatids at anaphase onset. Abnormally functioning separase is known to lead to chromosomal instability. Methods: The study comprises 349 breast carcinoma patients treated in Central Hospital of Central Finland. The prognostic value, role as a proliferation marker and regulatory interactions of separase are evaluated by immunohistochemical and double- and triple-immunofluorescence (IF) detections based on complete clinical data and >22-year follow-up of the patient material. Results: In our mat…

0301 basic medicineentsyymitCancer Researchcyclin B1proliferationenzymesMitosismarkersBreast NeoplasmsBiologyta311103 medical and health sciencesbreast cancerBreast cancerseparaseBiomarkers TumormedicineHumansProliferation MarkerCyclin B1Molecular DiagnosticsSurvival rateNeoplasm StagingAnaphaseGeneticsrintasyöpäsecurinPrognosista3122medicine.diseaseSurvival Rate030104 developmental biologyOncologySecurinmarkkeritCancer researchFemaleSeparaseBreast carcinomaESPL1British Journal of Cancer
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Transcriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells

2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License .

MaleComputingMilieux_LEGALASPECTSOFCOMPUTINGTranscriptomeCytosolRas-GRF1Insulin-Secreting CellsGlucose homeostasisPromoter Regions GeneticOligonucleotide Array Sequence AnalysisMice KnockoutGeneticsCell biologySecurinERKPhenotypemedicine.anatomical_structureMitogen-Activated Protein KinasesBeta cellSignal transductionResearch ArticleSignal TransductionBiotechnologyCell signalingMedicina InvestigacióMedicinaPancreatic isletsBiologyGeneticsmedicineAnimalsCell LineagePttg1TranscriptomicsTranscription factorBinding Sitesras-GRF1Gene Expression ProfilingPancreatic isletsBeta cellsMolecular Sequence AnnotationGlucose Tolerance TestMice Inbred C57BLPàncrees MalaltiesGenetic LociData_GENERALTranscriptional factorsras ProteinsCalciumRasGrf1RasBMC Genomics
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Securing Pathways into Teaching to Attract More Applicants ? An Analysis of the ‘Pre-professionalisation’ Scheme for Undergraduate Students in France…

2022

Securing PathwaysTeaching[SHS.EDU] Humanities and Social Sciences/EducationUndergraduate StudentsFranceAnalysisPre-professionalisation Scheme
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Skuteczność zabezpieczeń podatkowych ustanowionych przed ogłoszeniem upadłości po dacie ogłoszenia upadłości. Glosa do wyroku Wojewódzkiego Sądu Admi…

2021

Problematyka skuteczności zabezpieczeń ustanawianych na majątku podatnika, co do którego następnie sąd upadłościowy ogłosił upadłość, budzi liczne kontrowersje i problemy natury praktycznej. Wbrew stanowisku Wojewódzkiego Sądu Administracyjnego (WSA) w Białymstoku1 nie można przyjąć założenia, że zabezpieczenia ustanowione w trybie regulacji podatkowych mają pierwszeństwo przed zasadami prawa upadłościowego oraz są wykonalne i skuteczne także po ogłoszeniu upadłości podatnika. Przyjęcie takiego rozwiązania oznaczałoby uprzywilejowanie określonej grupy wierzycieli. Tym samym, mając na uwadze respektowanie tych zasad w postępowaniu cywilnym i karnym, należy uznać stanowisko WSA w Białymstoku …

taxpayeregzekucjabankruptSecuring tax liabilitiescreditorsupadłyenforcementupadłośćwierzycieleZabezpieczenie zobowiązań podatkowychbankruptcypostępowanie upadłościowepodatnikbankruptcy proceedingsDoradztwo Podatkowe Biuletyn Instytutu Studiów Podatkowych
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