Search results for "ship"
showing 10 items of 6731 documents
Ferricytochrome c encapsulated in silica nanoparticles: structural stability and functional properties.
2004
Using a modified sol-gel technique, we have succeeded in encapsulating ferric cytochrome c in silica nanoparticles obtained from hydrolysis and polycondensation of tetramethylorthosilicate. Particles dimensions have been determined with dynamic light scattering; this technique yields an hydrodynamic radius of about 100 nm, each nanoparticle containing about 10(2)-10(3) proteins. If stored in the cold at low ionic strength, nanoparticles are stable for more than one week, even if a slow radius increase with time is observed. CD measurements show that encapsulated proteins exhibit substantially increased stability against guanidinium hydrochloride induced denaturation. Reduction kinetics of e…
New benzothieno[3,2-d]-1,2,3-triazines with antiproliferative activity: synthesis, spectroscopic studies, and biological activity.
2014
New benzothieno[3,2-d]-1,2,3-triazines, together with precursors triazenylbenzo[b]thiophenes, were designed, synthesized and screened as anticancer agents. The structural features of these compounds prompted us to investigate their DNA binding capability through UV–vis absorption titrations, circular dichroism, and viscometry, pointing out the occurrence of groove-binding. The derivative 3-(4-methoxy-phenyl)benzothieno[3,2-d]-1,2,3-triazin-4(3H)-one showed the highest antiproliferative effect against HeLa cells and was also tested in cell cycle perturbation experiments. The obtained results assessed for the first time the anticancer activity of benzothieno[3,2-d]-1,2,3-triazine nucleus, and…
Binding of several phenothiazine neuroleptics to a common binding site of alpha 1-acid glycoprotein, orosomucoid.
1983
The interaction of several phenothiazine neuroleptics with alpha 1-acid glycoprotein was investigated using circular dichroism and equilibrium dialysis techniques. For chlorpromazine only, one high-affinity binding site of the protein was found. The binding of the drug to this single site generated typical polyphasic extrinsic Cotton effects. Since several other phenothiazine neuroleptics gave qualitatively comparable extrinsic Cotton effects in the presence of alpha 1-acid glycoprotein and potently inhibited the binding of chlorpromazine to the single site, it was concluded that all phenothiazine derivatives investigated bound preferentially to only one common binding site of the alpha 1-a…
Effects of seniority, gender and geography on the bibliometric output and collaboration networks of European Research Council (ERC) grant recipients.
2019
Assessing the success and performance of researchers is a difficult task, as their grant output is influenced by a series of factors, including seniority, gender and geographical location of their host institution. In order to assess the effects of these factors, we analysed the publication and citation outputs, using Scopus and Web of Science, and the collaboration networks of European Research Council (ERC) starting (junior) and advanced (senior) grantees. For this study, we used a cohort of 355 grantees from the Life Sciences domain of years 2007-09. While senior grantees had overall greater publication output, junior grantees had a significantly greater pre-post grant award increase in …
Citizenship Education at the Republican Schools in France: Comprehensive Review and Teachers' Points of View
2019
Citizenship Education at the Republican Schools in France: Comprehensive Review and Teachers' Points of View This thesis deals with citizenship education in France, a subject that has been on the agenda for some thirty years and the object of intense debates, especially in a national community deeply shocked by recent terrorist attacks. As there are but few studies on the subject, especially from an empirical perspective (Bozec, 2016), our objective is a comprehensive review of citizenship education in France. We explore how the subject is conceived officially and integrates national curricula as well as how it is implemented at school. In fact, we seek to answer the question: how is citize…
Main needs and best practices in citizenship and intercultural education in Europe
2008
Training citizenship and intercultural education in Europe: Main needs and best practices
2008
Tra.C.I.E. project: Training Citizenship and Intercultural Education in Europe
2009
The paper is a report about the project “Training Citizenship and Intercultural Education: methods and resources for adult learning (Tra.C.I.E.)”, that is funded by EC (LLP – Grundtvig, Multilateral projects). It involves organizations of 5 European countries (Italy, Bulgaria, Portugal, Romania, and Spain) and it is aimed at developing a set of curricula for the training of the educators in the field of Intercultural and Citizenship Education. During the first stages of the project, an analysis of the main needs of the target groups in the countries of the consortium was performed. At the same time, through the exchange of best practices a set of training resources was selected. Then, on th…
Violences scolaires et culture (s)
2005
La question de la violence scolaire est d'abord une question politique. L'École est un lieu politique parce que s'y jouent des jeux et enjeux de pouvoir dont la violence scolaire est la forme émergente. L'École de la République est aujourd'hui confrontée à des demandes croissantes de pluralité culturelles et cultuelles. Comment est-il possible de comprendre les formes de violence et de déviances scolaires ? Voici les résultats d'un colloque organisé dans et par un lycée.
La polis y el polites: orígenes y características de la categoría de ciudadanía | The Polis and the Polites: origins and characteristics of the citiz…
2016
RESUMEN. El autor describe algunos elementos distintivos del estatus y de las funciones del ciudadano en la Atenas del siglo V asi como en el contexto democratico ateniense, en el que nacio la figura del ciudadano. Pone de relieve el caracter excluyente y las instituciones "limitadas" que hacen de la ciudadania un estatus exclusivo, reservado para los hombres, para los hijos de ambos padres atenienses y que de esa manera excluia a los extranjeros residentes (metecos), a los otros griegos y a los barbaros. A partir de la categoria aristotelica de "ciudadano en sentido absoluto", el autor muestra como incluso dentro de la comunidad de los atenienses libres, por varias razones, grupos como el …