Search results for "ship"

Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes.

2009

Reaction kinetics of betanin and its aglycone betanidin towards peroxyl radicals generated from the azo-initiated oxidation of methyl linoleate in methanol, and of a heterogeneous aqueous/soybean phosphatidylcholine liposomal system, were studied by monitoring formation of linoleic acid hydroperoxides and consumption of the pigments. Betanin was a weak retarder in methanol, and an effective chain breaking antioxidant in the liposomal model, indicating that kinetic solvent effects and partition in lipid bilayers may affect its activity. Betanidin behaved as a chain terminating antioxidant in both models. Kinetic parameters characterizing peroxyl radical-scavenging activity showed that betani…

Comparative study to predict toxic modes of action of phenols from molecular structures.

2013

Quantitative structure-activity relationship models for the prediction of mode of toxic action (MOA) of 221 phenols to the ciliated protozoan Tetrahymena pyriformis using atom-based quadratic indices are reported. The phenols represent a variety of MOAs including polar narcotics, weak acid respiratory uncouplers, pro-electrophiles and soft electrophiles. Linear discriminant analysis (LDA), and four machine learning techniques (ML), namely k-nearest neighbours (k-NN), support vector machine (SVM), classification trees (CTs) and artificial neural networks (ANNs), have been used to develop several models with higher accuracies and predictive capabilities for distinguishing between four MOAs. M…

Design of new DNA-interactive agents by molecular docking and QSPR approach

2010

The design of new series of pyrrolo-pyrimidine derivatives, further annelated with a third heterocycle of different size, which also present several chain shape moieties of variable length and with different physico-chemical character, is reported. In this contribution we showed that the combination of docking-based and QSPR-based methods could lead to good models for ligand-DNA interaction prediction. By means of these computational approaches on 360 proposed inhibitors, we were able to select the most promising candidates as DNA-interactive drugs potentially endowed with antitumor activity.

Differential in vitro Anti-HIV Activity of Natural Lignans

1990

Abstract Two naturally occurring lignanolides, isolated from the tropical climbing shrub Ipomoea cairica, (-)-arctigen in and (-)-trachelogen in , were found to inhibit strongly replication of human immunodeficiency virus type 1 (HIV-1; strain HTLV-III B) in vitro. At a concentration of 0.5 (μм , (-)-arctigenin and (-)-trachelogenin inhibited the expression of HIV-1 proteins p 17 and p24 by 80 -90 % and 60 -70 % , respectively. The reverse transcriptase activity in the cul­ture fluids was reduced by 80 -90 % when the cells (HTLV-III B/H 9) were cultivated in the presence of 0.5 μм (-)-arctigen in or 1 μм (-)-trachelogenin . At the same concentrations, the formation of syncytia in the HTLV-I…

ANALYSIS OF THE DOSE-RESPONSE CURVE TO SODIUM NITRITE IN ISOLATED RAT AORTA

1978

Uztvertais sociālais atbalsts, apmierinātība ar partnerattiecībām un depresijas simptomi sievietēm 4 – 6 nedēļas pēc dzemdībām

2017

Pētījuma jautājumi, kuriem vēlos noskaidrot atbildes pētījumā rezultātā ir, kāda saistība pastāv starp uztverto sociālo atbalstu, apmierinātību ar partnerattiecībām un depresijas simptomiem sievietēm 4 – 6 nedēļas pēc dzemdībām. Otrs pētījuma jautājums ir noskaidrot, kā apmierinātība ar partnerattiecībām un uztvertais sociālais atbalsts prognozē depresijas simptomus sievietēm 4 – 6 nedēļas pēc dzemdībām. Pētījumā piedalījās 31 sieviete, kura bija 4 – 6 nedēļas pēc dzemdībām. Svarīgi nosacījumi bija, lai sievietei būtu piedzimis pirmais bērniņš un lai viņš būtu vesels, kas tika novērtēts pēc Apgares jaundzimušā veselības stāvokļa. Pētījumā tika izmantoti trīs pētījuma instrumenti. Lai noskai…

Opposite vascular activity of (R)-apomorphine and its oxidised derivatives. Endothelium-dependent vasoconstriction induced by the auto-oxidation meta…

2003

We have synthetised a series of oxidised apomorphine derivatives (orto and para quinones 2-5), in order to analyse their vascular activity. We have performed radioligand binding assays on rat cortical membranes and functional studies on rat aortic rings. Instead the relaxant activity exhibited by (R)-apomorphine, o-quinones 2, 4, show contractile activity dependent on endothelium in rat aortic rings. Compound 2, the main metabolite of (R)-apomorphine auto-oxidation, was the product which showed enhanced contractile activity by a complex mechanism related to activation of Ca(2+) channels through release and/or inhibition of endothelial factors. Moreover, this compound disrupts the endothelia…

Reactive oxygen species (ROS) generation inhibited by aporphine and phenanthrene alkaloids semi-synthesized from natural boldine.

2004

Four phenanthrene and one aporphine alkaloids semi-synthesized from boldine were evaluated for their inhibitory effect on reactive oxygen species (ROS) generation. ROS generation by neutrophils stimulated with N-formyl-methionyl-leucyl-phenylalanine was inhibited in a concentration dependent manner. Alkaloids exerted similar inhibitory effect in the hypoxanthine-xanthine oxidase system than in stimulated neutrophils, which could be attributed to a direct ROS scavenging activity. None of the alkaloids assayed had any effect on xanthine oxidase activity. Therefore the synthesized alkaloids might constitute an alternative therapy in inflammation disorders in which ROS generation is involved.

Gelchromatographie. 8. Mitt.: Vernetzte copolymere des vinylacetats

1969

Die Eigenschaften von vernetzten Copolymeren des Vinylacetats wurden in Abhangigkeit von den Herstellungsbedingungen gepruft. Als Vernetzungsmittel dienten Divinyladipat und Butandiol-(1.4)-divinylather. Mit homogen-vernetzten Gelen konnen Ausschlusmolekulargewichte bis etwa 4000 erzielt werden: zwischen dem spezifischen Gelbettvolumen und dem Ausschlusmolekulargewicht besteht eine lineare Beziehung. Die heterogen-vernetzende Copolymerisation des Vinylacetats in Gegenwart verschiedener inerter Verdunnungsmittel fuhrt zu Gelen mit Ausschlusmolekulargewichten uber 106. Die vernetzten Copolymeren wurden durch ihre scheinbare Dichte, durch die Aufnahme von Losungs- und Fallungsmitteln, durch di…

The Company Clusters Power in Tourism Destinations: The Network Configuration and the Business Organisation

2022

Better and greater coordination and integration between companies are essential for tourist destination development processes improving competitiveness. Moreover, it is difficult to imagine that all companies can cooperate. In this way, we can imagine finding a group of companies that, for several reasons, decide to cooperate, creating some clusters as small groups. Companies with stable connections with other clusters or relevant companies could be relevant and central to Tourism Destination (TD) management. In this way, the knowledge of network articulation seems to be critical for TD management business dynamics. In most cases, the relationships are hidden and not formalised, increasing …