Search results for "ships"
showing 10 items of 443 documents
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor
2013
The Eph–ephrin system plays a critical role in tumor growth and vascular functions during carcinogenesis. We had previously identified cholanic acid as a competitive and reversible EphA2 antagonist able to disrupt EphA2-ephrinA1 interaction and to inhibit EphA2 activation in prostate cancer cells. Herein, we report the synthesis and biological evaluation of a set of cholanic acid derivatives obtained by conjugation of its carboxyl group with a panel of naturally occurring amino acids with the aim to improve EphA2 receptor inhibition. Structure-activity relationships indicate that conjugation of cholanic acid with linear amino acids of small size leads to effective EphA2 antagonists whereas …
Homopolymerization of styrenic monomers and their copolymerization with ethylene using group 4 non‐metallocene catalysts
2020
Homopolymerization of styrenic monomers (St, p ‐Me‐St, p ‐t Bu‐St, p ‐t BuO‐St) and their copolymerization with ethylene, with the use of [( t Bu2O2NN′)ZrCl]2(μ‐O) (1 ) and ( t Bu2O2NN′)TiCl2 (2 ), where t Bu2O2NN′ = Me2N(CH2)2N(CH2‐2‐O−‐3,5‐t Bu2‐C6H2)2, is explored in the presence of MMAO and (i Bu)3Al/Ph3CB(C6F5)4. The ethylene/styrenic monomers copolymerization with 1 /MMAO produces exclusively copolymers with high activity and good comonomer incorporation whereas the other catalytic systems yield mixtures of copolymers and homopolymers. The use of p ‐alkyl styrene derivatives instead of styrene raises the catalytic activity, comonomer incorporation and molecular weights of the copolyme…
Separated Children’s Migration in the Mediterranean Sea. An Ethnohistorical Perspective
2016
In the imaginary of Italian people, the Island of Lampedusa (Italy) has always been considered a paradise destination for summer holidays. The beauty of this small island at the heart of the Mediterranean Sea, far from big harbors and cities, with its rich biodiversity and unspoilt nature, has made it a national and international tourist attraction. However, in recent years its name become associated with scenes of tragic, desperate journeys made by people of different origins trying to reach Europe from North African coasts. This shift exists not only in Italian people’s perception, but also all over the world, as the news related to Lampedusa and other Italian areas affected by this pheno…
Concurrent and lagged effects of counterdispositional extraversion on vitality
2020
Abstract There are two contrasting perspectives on the effects of state extraversion. One states that people benefit from behaving extraverted, regardless of their level of trait extraversion. The second entails that behaving concordant to one’s trait is natural while deviations from the trait level— counterdispositional behaviors—are effortful to maintain, leading to mental fatigue. We test the possibility that both perspectives are correct, with beneficial effects of high state extraversion showing immediately, while the depleting counterdispositional effects are delayed. Experience sampling data from 67 employees (N = 1,664), shows that extraverted behaviors are associated with high leve…
Extraversion and performance approach goal orientation : An integrative approach to personality
2019
Abstract Research shows that extraversion is unrelated to performance approach goal orientation, both at the trait- and the state-level. However, since previous studies have either focused on the trait- or the state-level, such a conclusion may be premature. Building upon the idea that acting against one’s trait consumes self-control resources, we reason that within-person deviations from one’s level of trait extraversion might negatively relate to performance approach goal orientation. Using experience sampling data from 47 employees across 10 days (N = 307), we found that deviations from one’s trait extraversion levels are associated with lower levels of performance approach goal orientat…
Joint route planning under varying market conditions
2007
PurposeTo provide empirical evidence on the level of savings that can be attained by joint route planning and how these savings depend on specific market characteristics.Design/methodology/approachJoint route planning is a measure that companies can take to decrease the costs of their distribution activities. Essentially, this can either be achieved through horizontal cooperation or through outsourcing distribution to a logistics service provider. The synergy value is defined as the difference between distribution costs in the original situation where all entities perform their orders individually, and the costs of a system where all orders are collected and route schemes are set up simulta…
What are the risk and protective factors for the well-being of adolescents with CF?
2021
La fibrosis quística (FQ) es una enfermedad crónica y hereditaria que compromete la vida de quienes la padecen, y se hace especialmente importante su impacto en la adolescencia. El afrontamiento que estos pacientes y sus familiares hagan de estas circunstancias que les han tocado vivir, puede mejorar o empeorar el curso y desenlace de la enfermedad. El objetivo es conocer los factores de riesgo y protectores que influyen en el bienestar de los adolescentes con FQ. Para ello se realizó una búsqueda bibliográfica de la literatura científica siguiendo la guía PRISMA en las siguientes bases de datos: Web of Science, ProQuest y Scopus. Se incluyeron artículos centrados en factores psicológicos d…
Famiglie, disagio e servizio sociale
2019
Il volume raccoglie contributi che intendono disvelare la natura sociale e culturale della famiglia. Gli autori dei contributi hanno messo in evidenza come la famiglia, lungi dall'essere una entità ovvia e data per scontata, sia invece il prodotto di aspettative, comportamenti socialmente strutturati, oltre che di negoziazioni e di rapporti di potere e dinamiche, talvolta profondamente conflittuali. The volume collects contributions that intend to reveal the social and cultural nature of the family.
La generatività familiare. Nuove prospettive di studio in educazione
2019
The paper aims to present, through a pedagogical approach, the concept of family generativity, without neglecting its limits and critical points. In addition to E.H. Erikson’s well-known studies, the concept of generativity occupies a crucial position for some scholars of symbolic-relational area, who explain it as an essentially relational construct: it is the value of the relationship between the generations. The analysis underlines how the intergenerational dimension, which traverses the couple and the family, is at the origin of the family generativity as it develops and grows thanks to the donative sources within the family systems. Therefore, it’s a task that delineates itself as esse…
Informant discrepancies in perceived parental psychological control, adolescent autonomy, and relatedness psychological needs
2021
Abstract Framed from Self-Determination Theory and Family Systems Theory, the present multi-informant study sought to contribute to a better understanding of the relations between discrepancies in parents' and adolescents' perceptions of parental psychological control and satisfaction of adolescents' needs for autonomy and relatedness. Participants were 190 Italian intact families in which an adolescent was present (Mage = 16.47 years, SDage = 1.41). Our findings highlighted that: (1) adolescents generally tended to perceive higher levels of psychological control than their parents reported; (2) adolescents tended to rate mothers' psychological control higher than the mothers themselves, wh…