Search results for "ships"
showing 10 items of 443 documents
Homology models of melatonin receptors: challenges and recent advances
2013
Melatonin exerts many of its actions through the activation of two G protein-coupled receptors (GPCRs), named MT1 and MT2. So far, a number of different MT1 and MT2 receptor homology models, built either from the prototypic structure of rhodopsin or from recently solved X-ray structures of druggable GPCRs, have been proposed. These receptor models differ in the binding modes hypothesized for melatonin and melatonergic ligands, with distinct patterns of ligand-receptor interactions and putative bioactive conformations of ligands. The receptor models will be described, and they will be discussed in light of the available information from mutagenesis experiments and ligand-based pharmacophore …
We Become People in Architecture
2016
Attraverso lo studio del Catalogo Breve del 12 ° Mostra Internazionale di Architettura della Biennale di Venezia del 2010, People meet in Architecture, sotto la direzione di Kazuyo Sejima, cercheremo di interpretare: un lavoro scritto, dei disegni e alcune foto. La Mostra ha permesso ai visitatori di conoscere idee derivanti da diversi contesti con un presupposto che l'architettura, come spazio costruito per gli stili di vita in continua evoluzione, è sempre stato uno specchio della coscienza collettiva. Per mezzo di questo lavoro cercheremo di capire come i contenuti della Mostra, di cui con l'uso della essenzialità grafica di un catalogo, consente di conoscere e studiare piani intrisi di …
Współczesne związki intymne w sieci przeszkód i sprzeczności
2020
W artykule przyglądam się przeszkodom i sprzecznościom, które wynikają ze zmienności naszej rzeczywistości i z jednej strony są charakterystyczne dla czasów, w których żyjemy – dlatego są nieredukowalne – a z drugiej utrudniają lub nawet uniemożliwiają ludziom tworzenie satysfakcjonujących związków intymnych. Traktowane jako opresyjne i niesprawiedliwe nierówności w związku, konieczność kompromisu przy dominacji różnych odmian indywidualizmu i koncentracji na „ja” czy negocjacyjny charakter relacji komplikują budowanie szczęśliwych związków oraz tak ważną w nich intymności.
New Families as an Educational Emergency
2017
One phenomenon typical of late-modern Western societies is the extreme pluralisation of family forms, a true and proper archipelago of families, so that: the family can no longer be reasonably discussed in the singular, just as well as each couple seems to form a «mixed couple» . Observing the data describing this phenomenon and any perceived trends, prompt a first general consideration, from an educational perspective: the aspects related to couple formation, the choice of whether to marry, the preferred family forms, all highlight a breakup between the older and the younger generations. In short, we are confronted with a new culture of human relationships: this new culture sets new symbol…
Ether-Lipids Are Involved in Retinal Vegf Expression and in Postnatal Hyaloid Vessel Regression
2009
Purpose:Ether-lipids are phospholipids that represent about 13% of retinal lipids and whose exact functions remain unknown. However, the preferential esterification of polyunsaturated fatty acids (PUFAs) at the sn-2 position of ether-lipids and their liberation by an ether-lipid-specific phospholipase A2 suggest their involvement in cell signaling processes. Based on the data showing the persistence of the hyaloid vasculature in ether-lipid-deficient mice (DAPAT-/- mice, Rodemer et al Hum Mol Genet 2003), we further investigated the molecular mechanisms by which ether-lipids may regulate hyaloid vessels regression during post-natal development. Methods:C57BL/6 mice were treated at birth eit…
Simple Relationships for the Optimal Design of Paired Drip Laterals on Uniform Slopes
2016
Microirrigation plants, if properly designed, allow water use efficiency to be optimized and quite high values of emission uniformity to be obtained in the field. It is known that disposing paired laterals, in which two distribution pipes extend in opposite directions from a common manifold, contribute to increasing water use efficiency. Recently, an analytical procedure has been proposed to optimally design paired drip laterals on uniform slopes under the assumption of neglect: (1) the variations of the emitters’ flow rate along the lateral, and (2) the local losses due to the emitters’ insertions. However, this procedure is not readily usable for every geometric and hydraulic characterist…
Can ‘Fellow of the European Board of Ophthalmology Subspecialty Diploma in Glaucoma,’ a subspecialty examination on glaucoma induce the qualification…
2016
From 2015, the examination of Fellow of the European Board of Ophthalmology Subspecialty Diploma in Glaucoma (FEBOS-Glaucoma) was launched by the European Board of Ophthalmology (EBO) in cooperation with the European Glaucoma Society (EGS). This opinion aims at disclosing the background of the examination, prerequisite to the examination, and the value of the FEBOS-Glaucoma diploma.
The logic of the gift and the bonding value: a new perspective for business management
2011
PurposeThis paper aims to conceptualize business relationships so as to include in these dimensions of both gift and gratuity, to develop the concept of “bonding value”, and to offer some ideas for the use of this within firms.Design/methodology/approachThe paper analyses the concept of “bonding value”, distinguishing it from the concepts of “exchange value” and “use value” that are normally used in business, and attempts to investigate its practical implications.FindingsThe paper shows how evaluating both the relationships within the organization and between firm and stakeholders in terms of “bonding value” can have effects on the economic, organizational and social aspects of a firm's act…
Engaging in upward and downward comparisons as a determinant of relative deprivation at work
2003
A longitudinal study was conducted among 93 nurses to determine the role of comparing one's performance with that of one's colleagues in the increase versus decrease of perceived relative deprivation at work over a period of one year. Relative deprivation at T2 had increased particularly among those high in social comparison orientation (Gibbons & Buunk, 1999) who at T1 (1) more frequently engaged in upward comparisons; (2) more frequently derived positive as well as negative feelings from such comparisons; and (3) more frequently derived negative feelings from downward comparison. Moreover, engaging in downward comparison also led to an increase in perceived relative deprivation at T2.…
Making and breaking relationships on social media: the impacts of brand and influencer betrayals
2021
This study considers how the relationships between social media influencers, brands and individuals are intertwined on social media and analyses the spill-over effects of feelings of betrayal. An experimental design with two transgression scenarios (influencer vs. brand) was created, and 250 individuals were recruited to participate in the study. The results show that a perceived betrayal by a brand can negatively affect the perceived coolness of the social media influencer that has endorsed the brand, as well as the parasocial relationships that followers have with the influencer. Accordingly, a perceived betrayal by a social media influencer can negatively affect attitudes, trust and purc…