Search results for "sif"

A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo

2015

AbstractShort peptide sequences from complementarity-determining regions (CDRs) of different immunoglobulins may exert anti-infective, immunomodulatory and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). In this sense, they resemble early molecules of innate immunity. C36L1 was identified as a bioactive light-chain CDR1 peptide by screening 19 conserved CDR sequences targeting murine B16F10-Nex2 melanoma. The 17-amino acid peptide is readily taken up by melanoma cells and acts on microtubules causing depolymerization, stress of the endoplasmic reticulum and intrinsic apoptosis. At low concentrations, C36L1 inhibited migration, invasion and proli…

Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors

2016

Novel rhodesain inhibitors were developed by combining an enantiomerically pure 3-bromoisoxazoline warhead with a 1,4-benzodiazepine scaffold as specific recognition moiety. All compounds were proven to inhibit rhodesain with Ki values in the low-micromolar range. Their activity towards rhodesain was found to be coupled to an in vitro antitrypanosomal activity, with IC50 values ranging from the mid-micromolar to a low-micromolar value for the most active rhodesain inhibitor (R,S,S)-3. All compounds showed a good selectivity against the target enzyme since all of them were proven to be poor inhibitors of human cathepsin L. Novel rhodesain inhibitors were developed by combining an enantiomeri…

Detection of natural killer T cells in mice infected with Rickettsia conorii.

2013

Little information is available regarding the role of natural killer T (NKT) cells during the early stage of Rickettsia conorii infection. Herein, C3H/HeN mice were infected with the Malish 7 strain of R. conorii. Splenocytes from these mice were analysed in the early stage of the infection by flow cytometry and compared with uninfected controls. Our results showed an increase in NKT cells in infected mice. Additionally, NKT interleukin (IL)-17(+) cells increased three days after infection, together with a concurrent decrease in the relative amount of NKT interferon (IFN)-γ(+) cells. We also confirmed a higher amount of NK IFN-γ(+) cells in infected mice. Taken together, our data showed tha…

Adaptación transcultural y validación de tres scores para la detección de riesgo de desnutrición pediátrica durante la hospitalización (PNRS, STAMP y…

2022

Introducción: La desnutrición en la población infantil hospitalizada, varía entre el 6% y el 32%, siendo la incidencia de pérdida de más del 2% de peso variable, entre 13,15% y 53,05%. Existen diversas escalas para valorar el riesgo de desnutrición ligada a la enfermedad para población infantil. Sin embargo, la carencia de estudios de validación adecuados y la ausencia de un criterio consensuado sobre cúal es el mejor parámetro para determinar la desnutrición, hace que la elección para su uso clínico deba realizarse con cautela. En base a criterios de extensión de uso, facilidad y rapidez de aplicación, las escalas PNRS, STAMP y STRONGkids, son las tres herramientas de valoración de riesgo …

Rigassificatori: e se l’Italia diventasse lo snodo d’Europa?

2006

The Effect of Mechanocatalytic Pretreatment on the Structure and Depolymerization of Willow

2020

In this study, the effect of a mechanocatalytic pretreatment on the structure of willow and sugar release from pretreated willow was explored. In the mechanocatalytic approach, the pretreatment consists of solvent-free impregnation with sulfuric acid and a mechanical treatment with ball milling. Willow sawdust and pretreated samples were analyzed with field emission scanning electron microscope and X-ray diffraction. The products in the sugar solution were determined as the total reducing sugars with the 3,5-dinitrosalicylic acid method and monosaccharides with capillary electrophoresis. According to the results, milling increased the sugar production, depending on the sulfuric acid load. T…

Risk map of transmission of urogenital schistosomiasis by Bulinus truncatus (Audouin, 1827) (Mollusca Gastropoda, Bulinidae) in Spain and Portugal

2019

Mapa del riesgo de contraer schistosomiasis urogenital provocada por Bulinus truncatus (Audouin, 1827) (Mollusca Gastropoda, Bulinidae) en España y Portugal Se da a conocer el mapa de la distribución geográfica de Bulinus truncatus en España y Portugal en el que se recopilan las localidades históricas y actuales, que coincide con el mapa del riesgo de contraer schistosomiasis urogenital provocada por este caracol de agua dulce. Se revisan las muestras de esta especie depositadas en el Museu de Ciències Naturals de Barcelona y en el Museo de Ciencias Naturales de Madrid, así como datos propios, incluidas algunas aportaciones inéditas. Este mapa permitirá conocer el área óptima de esta especi…

Banku riski un to vadīšanas metodes AS "Norvik banka"

2015

Izvēlētā bakalaura darba tēma ir aktuāla ne tikai no bankas efektīvas darbības viedokļa, bet arī no jebkura uzņēmuma, kurš veic saimniecisko darbību, pastāvēšanas viedokļa. Jo jebkurš uzņēmums, jebkura iestāde, kura veic komercdarbību ikdienā saskaras ar dažādiem riskiem. To neesamība vienkārši nav iespējama. Bakalaura darba mērķis ir identificēt nozīmīgākos riskus banku darbībā kopumā un to vadīšanas iespējas, apskatot šo jautājumu arī uz praktiska piemēra (par risku vadīšanu AS „Norvik banka”). Bakalaura darba mērķa sasniegšanai ir izvirzīti šādi uzdevumi: •Izanalizēt pieejamo zinātnisko literatūru par riskiem un to veidiem. •Noteikt svarīgākos riskus, ar kuriem bankas saskaras. •Izpētīt …

Isäntäkalan altistushistorian vaikutus Diplostomum pseudospathaceum -loisen tartuntamenestykseen ja genotyyppien välisiin vuorovaikutussuhteisiin

2016

Luonnossa isännät altistuvat usein monille loislajeille sekä niiden genotyypeille. Altistuminen tapahtuu usein eri aikaan johtuen loisinnan ajallisesta ja paikallisesta vaihtelusta, minkä seurauksena loisia vastaan kehittyvät immuunivasteet syntyvät vaiheittaisesti. Loiset voivat vaikuttaa toisiinsa suoraan kilpailemalla elintilasta tai resursseista, tai epäsuorasti isännän immuunijärjestelmän kautta. Kahden loisgenotyypin yhtäaikaisen tartunnan on aiemmissa tutkimuksissa havaittu kuormittavan isännän immuunijärjestelmää niin, että kummankin genotyypin tartuntamenestys on tällöin korkeampi. Tutkielmassani selvitin, miten isännän altistushistoria vaikuttaa loisten välisiin vuorovaikutussuhte…

Selection of spawning substratum by European river lampreys (Lampetra fluviatilis) in experimental tanks

2014

The selection of spawning substratum by the river lamprey (Lampetra fluviatilis) was studied in two experimental tanks with different flow conditions. In both tanks, four gravel sizes mixed with 15% sand were available to the test animals. In the tank with the lower current speed, lampreys selected in favour of the finest (2–8 mm) gravel size available against gravel sizes 4–20 mm and 8–40 mm. Selection was also significantly different in the tank with higher current speed where selection against the medium-sized substratum (4–20 mm) was evident, but there were no differences between selection for gravel sizes 2–8 mm, 2–40 mm and 8–40 mm relative to availability. Substratum selection and ob…