Search results for "skeleta"
showing 10 items of 3030 documents
The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms.
2015
Objectives:\ud The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.\ud \ud Methods:\ud Pharmacological manipulation of the activity of CRF receptors, CRF1 and CRF2, was performed in 3T3L1 white pre-adipocytes and T37i brown pre-adipocytes during in vitro differentiation. The expression of genes of the CRF/urocortin system and of markers of white and brown adipocytes was evaluated along with mitochondrial biogenesis and cellular oxygen consumption. Metabolic evaluation of corticosterone-deficient or supplemented Crhr1-null (Crhr1−/−) mice and their wild-type controls was performed alo…
Efectos de la aplicación de un analgésico de mentol previo al entrenamiento de la fuerza muscular sobre parámetros de dolor y capacidad funcional de …
2021
El dolor lumbar crónico (DLC) afecta a más del 30% de los adultos mayores que viven en la comunidad y es la afección musculoesquelética más prevalente en esta población, razón por la cual, se ha transformado en uno de los motivos de consulta más comunes entre las personas mayores quienes se atienden en servicios de atención primaria de salud. Es por esta razón, que el DLC es considerado hoy en día una “epidemia silenciosa” que impacta directamente en la funcionalidad y calidad de vida de las personas mayores con consecuentes costes sanitarios elevados que sobrecargan los sistemas de salud. A este hecho se suma que el origen de este síndrome es multifactorial, con lo cual el diagnóstico es i…
Neurophysiological Changes After Paired Brain and Spinal Cord Stimulation Coupled With Locomotor Training in Human Spinal Cord Injury
2021
Neurophysiological changes that involve activity-dependent neuroplasticity mechanisms via repeated stimulation and locomotor training are not commonly employed in research even though combination of interventions is a common clinical practice. In this randomized clinical trial, we established neurophysiological changes when transcranial magnetic stimulation (TMS) of the motor cortex was paired with transcutaneous thoracolumbar spinal (transspinal) stimulation in human spinal cord injury (SCI) delivered during locomotor training. We hypothesized that TMS delivered before transspinal (TMS-transspinal) stimulation promotes functional reorganization of spinal networks during stepping. In this p…
EMG-Assisted Muscle Force Driven Finite Element Model of the Knee Joint with Fibril-Reinforced Poroelastic Cartilages and Menisci
2020
Abnormal mechanical loading is essential in the onset and progression of knee osteoarthritis. Combined musculoskeletal (MS) and finite element (FE) modeling is a typical method to estimate load distribution and tissue responses in the knee joint. However, earlier combined models mostly utilize static-optimization based MS models and muscle force driven FE models typically use elastic materials for soft tissues or analyze specific time points of gait. Therefore, here we develop an electromyography-assisted muscle force driven FE model with fibril-reinforced poro(visco)elastic cartilages and menisci to analyze knee joint loading during the stance phase of gait. Moreover, since ligament pre-st…
Can Oscillatory Alpha-Gamma Phase-Amplitude Coupling be Used to Understand and Enhance TMS Effects?
2019
Recent applications of simultaneous scalp electroencephalography (EEG) and transcranial magnetic stimulation (TMS) suggest that adapting stimulation to underlying brain states may enhance neuroplastic effects of TMS. It is often assumed that longer-lasting effects of TMS on brain function may be mediated by phasic interactions between TMS pulses and endogenous cortical oscillatory dynamics. The mechanisms by which TMS exerts its neuromodulatory effects, however, remain unknown. Here, we discuss evidence concerning the functional effects on synaptic plasticity of oscillatory cross-frequency coupling in cortical networks as a potential framework for understanding the neuromodulatory effects o…
Cold Exposure Affects Lipid Metabolism, Fatty Acids Composition and Transcription in Pig Skeletal Muscle
2021
Cold exposure promotes glucose oxidation and modulates the lipid metabolism in adipose tissue, but it is still not fully clear whether cold exposure could affect meat quality and fatty acid metabolism in skeletal muscle of pig in vivo. Here, we kept finishing pigs under cold or room temperature overnight and determined the effects of cold exposure on meat quality, fatty acids composition and transcriptional changes in skeletal muscle of pigs. We found that cold exposure significantly reduced the meat colour24 h and pH24 h, without affecting carcass characteristics and other meat quality traits. Considerable changes were found in the proportions of individual fatty acids and the total conten…
Slight variations in components ratio affect odor pleasantness of a blending mixture
2009
International audience; Odors rely mainly on the perception of odorants mixtures but are commonly perceived as single undivided entities; nevertheless, the processes involved remain poorly explored. It has been reported that perceptual blending, based on configural olfactory processing, can lead odorant mixtures to give rise to an emergent odor quality not present in the components. Furthermore, very slight variations (just noticeable differences, jnd) in components concentrations were shown to be sufficient to modify the odor quality of a blending mixture. In the present study, we set out to examine whether jnd in components concentrations could also affect the odor pleasantness of a blend…
Postmortem Electrical Conductivity Changes of Dicentrarchus labrax Skeletal Muscle: Root Mean Square (RMS) Parameter in Estimating Time since Death
2022
Electric impedance spectroscopy techniques have been widely employed to study basic biological processes, and recently explored to estimate postmortem interval (PMI). However, the most-relevant parameter to approximate PMI has not been recognized so far. This study investigated electrical conductivity changes in muscle of 18 sea bass specimens, maintained at different room temperatures (15.0 °C; 20.0 °C; 25.0 °C), during a 24 h postmortem period using an oscilloscope coupled with a signal generator, as innovative technology. The root mean square (RMS) was selected among all measured parameters, and recorded every 15 min for 24 h after death. The RMS(t) time series for each anima…
Ocena stanu szkieletu u dzieci i młodzieży z cukrzycą typu 1 przy użyciu ilościowej metody ultradźwiękowej paliczków dłoni. Badanie pilotażowe
2008
Cel pracy. Ocena stanu szkieletu u dzieci i młodzieży z cukrzycą typu 1 przy użyciu ilościowej metody ultradźwiękowej paliczków dłoni. Materiał i metody. W badaniu wzięło udział 152 pacjentów, 82 chłopców i 70 dziewcząt z cukrzycą typu 1, w wieku – średnio: dziewczęta 13,11±2,93, chłopcy 12,89±3,12. Średni czas trwania choroby wynosił u dziewcząt 4,66±2,43, a u chłopców 4,19±2,36 lata. Średnia wartość hemoglobiny glikowanej HbA1c w dniu badania wynosiła w grupie dziewcząt 7,1±1,3%, a w grupie chłopców 7,2±1,2%. Grupę kontrolną stanowiło 219 zdrowych dzieci (121 chłopców i 98 dziewcząt), dobranych pod względem wieku i płci. Do oceny szkieletu użyto aparatu DBM Sonic 1200, który mierzy zależn…
The effects of whey protein with or without carbohydrates on resistance training adaptations
2015
Background: Nutrition intake in the context of a resistance training (RT) bout may affect body composition and muscle strength. However, the individual and combined effects of whey protein and carbohydrates on long-term resistance training adaptations are poorly understood. Methods: A four-week preparatory RT period was conducted in previously untrained males to standardize the training background of the subjects. Thereafter, the subjects were randomized into three groups: 30 g of whey proteins (n = 22), isocaloric carbohydrates (maltodextrin, n = 21), or protein + carbohydrates (n = 25). Within these groups, the subjects were further randomized into two whole-body 12-week RT regimens aimin…