Search results for "slip"

DYSLIPIDEMIA AND CARDIOVASCULAR RISK: FOCUS ON THE ROLE OF LOW HDL-CHOLESTEROL CONCENTRATIONS IN DEVELOPING ATHEROSCLEROTIC DISEASE AND IN ACCELERATI…

2009

Complex vein systems as a data source in tectonics: An example from the Ugab Valley, NW Namibia

2014

Abstract Neoproterozoic metaturbidites in the Lower Ugab Domain, Namibia, contain a complex network of four sets of quartz-calcite veins, overprinted by km-scale folds associated with four regional foliations. The veins formed by fluid overpressure predating the main deformation. Deformation structures developed at the junction of two mobile belts during the assembly of Gondwana, the NS Kaoko Belt, and the EW trending Damara Belt. Km-scale NS trending folds were initiated during EW constriction in the Kaoko Belt, while their further development and all subsequent events are related to constriction in the EW-Damara Belt, with coeval sinistral strike slip in the Kaoko Belt. Deformation of the…

Personalized management of dyslipidemias in patients with diabetes-it is time for a new approach (2022)

2022

AbstractDyslipidemia in patients with type 2 diabetes (DMT2) is one of the worst controlled worldwide, with only about 1/4 of patients being on the low-density lipoprotein cholesterol (LDL-C) target. There are many reasons of this, including physicians’ inertia, including diabetologists and cardiologists, therapy nonadherence, but also underusage and underdosing of lipid lowering drugs due to unsuitable cardiovascular (CV) risk stratification. In the last several years there is a big debate on the risk stratification of DMT2 patients, with the strong indications that all patients with diabetes should be at least at high cardiovascular disease (CVD) risk. Moreover, we have finally lipid lowe…

Nutraceuticals in Lipid-Lowering Treatment

2014

Lipid-lowering drugs may cause adverse effects and, although lipid targets may be achieved, a substantial residual cardiovascular (CV) risk remains. Treatment with agents mimicking proteins present in the body, such as incretin-based therapies, provided promising results. However, in order to improve lipids and CV risk, lifestyle measures remain important. Some researchers focused on nutraceuticals that may beneficially affect metabolic parameters and minimize CV risk. Chitosan, a dietary fiber, can regulate lipids with benefit on anthropometric parameters. The beneficial properties of dietary supplements (such as green tea extract, prebiotics, plant sterols, and stanols) on plasma lipids,…

Study of plastic deformation modes in zirconium by color image analysis

2004

Abstract Twinning, as a deformation mode, is a complement to slip. This paper deals with the study from a qualitative point of view, as well as from a quantitative one. Besides techniques widely used in materials science studies such as electron backscattered diffraction (EBSD) or X-ray diffraction (XRD), colour image analysis technique are presented here. Its results manage to confirm or complete the ones obtained, thanks to others methods.

An interface model for analysis of deformation behaviour of discontinuities

1996

An interface constitutive model is presented accounting for slip and sliding effects and also for dilatancy phenomena. The microslip effects are described by considering spherical asperity interaction with variation of contact area and generation of progressive or reverse slip zones. The incremental constitutive equations are derived with proper memory rules accounting for generation and annihilation of particular slip zones during the process of variable loading. It is further assumed that sliding of spherical contacts occurs along large asperities whose slope varies due to the wear process. The predicted shear and dilatancy curves are shown to provide close quantitative simulation of avai…

The influence of strain rate and presence of dispersed second phases on the deformation behaviour of polycrystalline D2O ice

2018

ABSTRACTThis contribution discusses results obtained from 3-D neutron diffraction and 2-D fabric analyser in situ deformation experiments on laboratory-prepared polycrystalline deuterated ice and ice containing a second phase. The two-phase samples used in the experiments are composed of an ice matrix with (1) air bubbles, (2) rigid, rhombohedral-shaped calcite and (3) rheologically soft, platy graphite. Samples were tested at 10°C below the melting point of deuterated ice at ambient pressures, and two strain rates of 1 × 10−5 s−1 (fast) and 2.5 × 10−6 s−1 (medium). Nature and distribution of the second phase controlled the rheological behaviour of the ice by pinning grain boundary migratio…

Microstructure and fabric development in ice: Lessons learned from in situ experiments and implications for understanding rock evolution

2014

Abstract In this contribution we present a review of the evolution of microstructures and fabric in ice. Based on the review we show the potential use of ice as an analogue for rocks by considering selected examples that can be related to quartz-rich rocks. Advances in our understanding of the plasticity of ice have come from experimental investigations that clearly show that plastic deformation of polycrystalline ice is initially produced by basal slip. Interaction of dislocations play an essential role for dynamic recrystallization processes involving grain nucleation and grain-boundary migration during the steady-state flow of ice. To support this review we describe deformation in polycr…

Shear banding mechanism of plastic deformation in LiF irradiated with swift heavy ions

2012

The effect of ion irradiation on the behavior of plastic deformation at micro- and nanoindentation on (001) face of LiF has been investigated. The irradiation was performed using heavy ions (U, Au, Ti and S) with energy in the range from 3 MeV to 2 GeV at fluences up to 5x1013 ions/cm2. In non-irradiated LiF, the indentation produces dislocation gliding on the {110} planes along the and directions. At high fluence irradiation, the resource of the dislocation slip along the preferable directions becomes exhausted due to immobilization of dislocations by radiation defects and their aggregates. The present study demonstrates the change of the mechanism of plastic deformation from homogenous di…

Inclisiran: a small interfering RNA strategy targeting PCSK9 to treat hypercholesterolemia

2022

Introduction: Inclisiran is a novel posttranscriptional gene silencing therapy that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) synthesis by RNA interference and has a potent, dose-dependent, durable effect in lowering LDL-C, and therefore is an effective drug to treat dyslipidemia, reducing the risk for acute cardiovascular (CV) events. It is safe and well-tolerated. Areas covered: This paper aims to review the mechanism of action of inclisiran while evaluating its efficacy and safety in the treatment of dyslipidemia from data of the clinical trials in the ORION program. Expert opinion: Data from the clinical trials in the ORION program demonstrated efficacy and safety o…