Search results for "soft"

A Parallel Face Detection System Implemented on FPGA

2007

In this paper, we introduce a methodology for designing a system for face detection and its implementation on FPGA. The chosen face detection method is the well-known convolutional face finder (CFF) algorithm, which consists in a pipeline of convolutions and subsampling operations. Our goal is to define a parallel architecture able to process efficiently this algorithm. We present a dataflow based architecture algorithm adequation (AAA) methodology implemented using the SynDEx software, in order to find the best compromise between the processing power and functionality requirement of each processor element (PE), and the efficiency of algorithm parallelization. We describe a first implementa…

Palermo: Virtual urban reconfiguration of some ancient squares and quarters

2013

The representation area is nowaday called upon to face new challenges for new computer technologies that have developed over the last few years. Visual communication and multimedia language experienced a radical change: representation and visualization, thought and image are based on the branch of communication and therefore on the trasmission of knowledge that cannot be separated from the interdisciplinarity. Digital imagery challenges more and more analog imagery, creating a scene that is independent from the constructed reality and sometimes reaching to overlap and merge with it: therefore the representation is no longer just a repetition of the real, but becomes itself an autonomous rea…

2019

Negative image-based (NIB) screening is a rigid molecular docking methodology that can also be employed in docking rescoring. During the NIB screening, a negative image is generated based on the target protein’s ligand-binding cavity by inverting its shape and electrostatics. The resulting NIB model is a drug-like entity or pseudo-ligand that is compared directly against ligand 3D conformers, as is done with a template compound in the ligand-based screening. This cavity-based rigid docking has been demonstrated to work with genuine drug targets in both benchmark testing and drug candidate/lead discovery. Firstly, the study explores in-depth the applicability of different ligand 3D conformer…

A Comparative Study of Nonlinear Machine Learning for the "In Silico" Depiction of Tyrosinase Inhibitory Activity from Molecular Structure.

2011

In the preset report, for the first time, support vector machine (SVM), artificial neural network (ANN), Baye- sian networks (BNs), k-nearest neighbor (k-NN) are applied and compared on two "in-house" datasets to describe the tyrosinase inhibitory activity from the molecular structure. The data set Data I is used for the identification of tyrosi- nase inhibitors (TIs) including 701 active and 728 inactive compounds. Data II consists of active chemicals for potency estimation of TIs. The 2D TOMOCOMD-CARDD atom-based quadratic indices are used as molecular descriptors. The de- rived models show rather encouraging results with the areas under the Receiver Operating Characteristic (AURC) curve …

Convolutional architectures for virtual screening

2020

Abstract Background A Virtual Screening algorithm has to adapt to the different stages of this process. Early screening needs to ensure that all bioactive compounds are ranked in the first positions despite of the number of false positives, while a second screening round is aimed at increasing the prediction accuracy. Results A novel CNN architecture is presented to this aim, which predicts bioactivity of candidate compounds on CDK1 using a combination of molecular fingerprints as their vector representation, and has been trained suitably to achieve good results as regards both enrichment factor and accuracy in different screening modes (98.55% accuracy in active-only selection, and 98.88% …

In silicoAntibacterial Activity Modeling Based on the TOMOCOMD-CARDD Approach

2015

In the recent times, the race to cope with the increasing multidrug resistance of pathogenic bacteria has lost much of its momentum and health professionals are grasping for solutions to deal with the unprecedented resistance levels. As a result, there is an urgent need for a concerted effort towards the development of new antimicrobial drugs to stay ahead in the fight against the ever adapting bacteria. In the present report, antibacterial classification functions (models) based on the topological molecular computational design-computer aided >rational> drug design (TOMOCOMD-CARDD) atom-based non-stochastic and stochastic bilinear indices are presented. These models were built using the li…

Environment-Aware RSSI Based Positioning Algorithm for Random Angle Interference Cancellation in Visible Light Positioning System

2021

International audience; Visible Light Positioning (VLP) is considered to be one of the most promising candidates for future Location Based Service (LBSs). The traditional Received Signal Strength Indication (RSSI) based VLP system is highly sensitized with receiver's orientation. However, the assumption of the receiver's orientation fixed or perfectly known is not realistic in practice. Thus, a random angle between receiver and the horizontal plane inevitably appears among localization, which extremely affects positioning results. This paper proposed an Environment-Aware RSSI based positioning algorithm for VLP system. It enables to mainly eliminate random angle interference without the hel…

Cybertext Challenge

2007

This article discusses the changing role of literature in the contemporary media landscape. Literary scholarship may well maintain its importance in the digitalizing world, but this requires it to engage in an open dialogue with cultural and media studies. It is important that more attention is paid to contemporary literature as well as to new media offering significant pedagogical possibilities, which should be better acknowledged. The article's main focus is on the emerging field of digital literature. Cybertextuality, especially, is fundamentally changing our notions of the integrity of a literary work, reading, writing and interpretation. I attempt to describe and put into context one …

Dance moves reflect current affective state illustrative of approach–avoidance motivation.

2013

Design follows politics? The visualization of political orientation in newspaper page layout

2017

This article explores how the political orientation of newspapers is reflected in their page layout. The authors compare the layouts of five German national quality newspapers exemplarily and exploratively in a combination of quantitative and qualitative analyses. Dimensions of comparison are typography, size, colouration, quantity and arrangement of elements. Results show systematic differences between the page layouts of left-wing and right-wing newspapers. These differences are reflected in the contrast of traditional and contemporary styles and also in the use of ideologically charged typography and colours. In addition, the size of headlines seems to be dependent on political extremity…