Search results for "soin"

Interactionist Approach to Visual Aesthetics in HCI

2021

Visual Aesthetics has gathered interest among scholars in HCI research. The growing interest stems from examinations of the aesthetic-usability effect (“what is beautiful is usable”), and possibly vice versa. Thus, numerous studies focus on understanding how we make sense and experience visual entities in interacting with technology. However, theoretical, and methodological stances vary, which impact conclusions of the studies conducted, and thus, affect design implications. Visual experience research in HCI lacks detailed conceptualizations of the constituents of visual experience and understanding of how these conceptualizations affect the overall research results through implicit methodo…

A Domino Ring‐Closure Followed by Retro‐Diels–Alder Reaction for the Preparation of Pyrimido[2,1‐ a ]isoindole Enantiomers

2016

A simple method was developed to prepare pyrimido[2,1-a]isoindole derivatives by using di-endo- and di-exo-ethyl 3-aminobicyclo[2.2.1]hept-5-ene-2-carboxylate enantiomers as chiral sources. The method is based on a domino ring-closure reaction of norbornene 2-aminohydroxamic acid followed by microwave-induced retro-Diels–Alder reaction. In the case of enantiomeric starting substances, the chirality is transferred from norbornene derivatives to pyrimido[2,1-a]isoindoles. The configurations of the synthesized compounds were determined by 1D and 2D NMR spectroscopy [based on 2D NOE cross-peaks and 3JH,H coupling constants] and X-ray crystallography.

Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

2015

Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI 50 mean values at low micromolar level (3.72–5.13 μM).

Isoindolo[1,5]benzoxazepines as potential antitumor and/or antiviral agents

2013

L'incertitude en médecine générale : sources, formes et accommodements possibles

2008

Cet article analyse la maniere dont l’incertitude se presente en medecine generale, a partir d’une enquete sociologique qualitative conduite sur plusieurs annees aupres de medecins generalistes francais. Les sources et formes de l’incertitude medicale y sont d’abord envisagees a la lumiere des categories classiques de Fox et des caracteristiques du contexte historique, economique et social d’exercice de la medecine generale en France. On examine ensuite la facon dont les generalistes s’accommodent de l’incertitude et stabilisent plus ou moins une attitude par rapport a cette donnee importante de leur pratique. Le propos aboutit a une cartographie des positionnements des generalistes qui ren…

Harmonian opetus unkarilaista säveltapailumetodia hyödyntäen Lahdessa

2014

Tämän maisterintutkielman tarkoitus on selvittää, miten harmoniaa opetetaan musiikin perusteissa Lahdessa. Kiinnostuin aiheesta toimiessani musiikin perusteiden opettajana Lahden konservatoriossa. Unkarilaisen säveltäjä ja musiikkipedagogi Zoltán Kodályn ajatuksiin perustuvaa säveltapailumenetelmää on käytetty Lahden konservatoriossa pääasiallisena opetusmenetelmänä ja halusin selvittää, miten menetelmää on sovellettu harmonian opetuksessa ja mitkä ovat sen edut. Koska teorian ja säveltapailun opetusta on aiemmin moitittu irralliseksi käytännöstä, halusin selvittää, käytetäänkö opetuksessa apuna soittimia. Tutkimus on laadullinen haastattelututkimus ja se toteutettiin keväällä 2013. Haastat…

Hankintamalleista henkilöstösuunnitteluun: hankinnan osaajat koolla Jyväskylässä

2014

Novel Lipophilic Lanthanide Bis-Phthalocyanines Functionalized by Pentadecylphenoxy Groups: Synthesis, Characterization and UV-Photostability

2012

Novel sandwich-type phthalocyanines containing a rare earth metal core (Pr, Nd, Eu-Lu) and macrocycles peripherally substituted by pentadecylphenoxy groups were synthesized using a cardanol-based phthalonitrile precursor and the respective lanthanide acetate. Additionally, the metal free-base analog compound was studied for comparison. The purified reaction products were all found to be thick and viscous substances at room temperature, showing liquid crystalline behavior with a distinct increase in fluidity at ca. 40 ° C. The complexes are readily soluble in chloroalkyl solvents and dissolve fairly well in DMF with some tendency to form aggregates. Besides they are strongly hydrophobic and …

Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line

2022

A series of [1,2]oxazolo[5,4‐e]isoindole derivatives was evaluated against HL‐60 cell line and its multidrug resistance (MDR) variant, HL‐60R, resistant to doxorubicin and to other P‐gp substrates by overexpressing the efflux pump. They displayed antiproliferative activities, with IC50 values ranging from 0.02 to 5.5μM. In particular, the newly synthesized compound 4k produced synergistic effects in terms of cell growth inhibition and cell death induction either in combination with a Vinca alkaloid, Vinblastine, and a Taxane, Paclitaxel in HL‐60R cells. The study of the mechanism of action indicated that all compounds showed antimitotic activity through inhibition of tubulin polymerization.…

Algorithms and Organizing

2022

Abstract Algorithms are a ubiquitous part of organizations as they enable, guide, and restrict organizing at the level of everyday interactions. This essay focuses on algorithms and organizing by reviewing the literature on algorithms in organizations, examining the viewpoint of relationality and relational agency on algorithms and organizing, exploring the properties of algorithms, and concluding what these mean from an organizational communication viewpoint. Algorithms need data to be collected. The data are always biased, and algorithms exclude everything that is not in their code. They define what is seen as important. Their operating principles are opaque, and they are political due to…