Search results for "solu"
showing 10 items of 7577 documents
Prognostic role of soluble PD-1 and BTN2A1 in overweight melanoma patients treated with nivolumab or pembrolizumab: finding the missing links in the …
2023
Individual response to immune checkpoint inhibitors (ICIs) is currently unpredictable in patients with melanoma. Recent findings highlight a striking improvement in the clinical outcomes of overweight/obese patients treated with ICIs, which seems driven, at least in part, by programmed cell death protein 1 (PD-1)-mediated T-cell dysfunction. A putative role of butyrophilins (BTNs) is under investigation as a novel mechanism of cancer immune evasion and obesity-associated inflammation. This study investigates the role of baseline plasma levels of soluble PD-1 (sPD-1), soluble programmed cell death ligand 1 (sPD-L1), BTN2A1 (sBTN2A1), BTN3A1 (sBTN3A1), along with body mass index (BMI), as pr…
Calreticulin 3 gene polymorphism in celiac disease and effects of gluten on calreticulin localization and expression in epithelial cells in vitro
2008
Totalitarismo y lenguaje: el campo de concentración como espacio multilingüe y la figura del intérprete concentracionario
2020
espanolEn este trabajo se examinan las relaciones entre el poder absoluto y el lenguaje. Los campos de concentracion del regimen nacionalsocialista se entienden como el espacio donde se materializa la maxima expresion del totalitarismo. Al convertirse en sociedades forzadamente multilingues desde el inicio de la guerra, la lengua alemana puede convertirse, mas que nunca, en un instrumento mas de opresion al servicio del sistema: se deforma para convertirse practicamente en un protolenguaje violento yrudimentario, y su conocimiento por parte de los reclusos se relaciona siempre con las perspectivas de supervivencia. Ademas, se desarrolla una lengua franca que incorpora rasgos de varios idiom…
Aggregation of Free-Base Octacarboxyphthalocyanine in Aqueous Solutions
1999
Results of spectral (UV-VIS) investigations on the aggregation phenomena of the freebase 2,3,9,10,16,17,23,24-octacarboxypthalocyanine are reported. Phthalocyanine exists mainly in associated (aggregated) froms in water. The aggregates are present even in very diluted (10-7 -10-6 mol/dm-3) solutions. The hydrogen bonding between the carboxyl groups of the adjacent molecules in considered. The increase in pH and temperature, as well as the presence of the cationic surfactant and alcohols (in an appropriate quantity) cause a prtial or full disaggregation. The spectrum of the monomeric phthalocyanine from has been observed. The increase in H2Pc(COOH)8 concentration, the decrease in pH, as well…
Influence of Anion and Cation Structure of Ionic Liquids on Carboxylic Acids Extraction
2019
A recently proposed new mechanism and a model of reactive extraction of carboxylic acids by hydrophobic ionic liquids (ILs) was tested on five systems from published as well as from new equilibrium data on liquid-liquid extraction of butyric and lactic acids (BA and LA) from aqueous solutions. Two phosphonium and one ammonium ILs were used. The model describes experimental data for all systems with a good fit. The mechanism of acid extraction by ILs is very similar for all tested systems. This indicates a more general validity of the developed model. The model allows deeper understanding of regularities in carboxylic acid extraction by hydrophobic ILs. Stability constants of the first acid-…
STAT5b is a key effector of NRG-1/ERBB4-mediated myocardial growth
2023
The growth factor Neuregulin-1 (NRG-1) regulates myocardial growth and is currently under clinical investigation as a treatment for heart failure. Here, we demonstrate in several in vitro and in vivo models that STAT5b mediates NRG-1/EBBB4-stimulated cardiomyocyte growth. Genetic and chemical disruption of the NRG-1/ERBB4 pathway reduces STAT5b activation and transcription of STAT5b target genes Igf1, Myc, and Cdkn1a in murine cardiomyocytes. Loss of Stat5b also ablates NRG-1-induced cardiomyocyte hypertrophy. Dynamin-2 is shown to control the cell surface localization of ERBB4 and chemical inhibition of Dynamin-2 downregulates STAT5b activation and cardiomyocyte hypertrophy. In zebrafish e…
Estudios sobre la enseñanza y aprendizaje de la resolución aritmética de problemas usando un sistema tutorial inteligente
2021
La resolución de problemas siempre ha ocupado un lugar importante en los currículos de matemáticas tanto en educación primaria como en educación secundaria. Un tipo de problemas, particularmente frecuente, son aquellos en los que la información viene dada mediante una narración en la que se describen situaciones cotidianas en las que participan cantidades. Estos problemas verbales son unos de los primeros a los que se enfrentan los estudiantes en su etapa escolar y que los acompañan hasta la finalización de la etapa secundaria. De manera general, los resultados mostrados en el estudio PISA (OECD, 2014a) ponen de manifiesto que la resolución de problemas matemáticos escolares y los problemas…
Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium.
2022
Gap junctions are intercellular channels that permit the transfer of ions and small molecules between adjacent cells. These cellular junctions are particularly dense in the retinal pigment epithelium (RPE), and their contribution to many retinal diseases has been recognized. While gap junctions have been implicated in several aspects of RPE physiology, their role in shaping the electrical properties of these cells has not been characterized in mammals. The role of gap junctions in the electrical properties of the RPE is particularly important considering the growing appreciation of RPE as excitable cells containing various voltage-gated channels. We used a whole-cell patch clamp to measure …
Uptake of actinides by calcium silicate hydrate (C-S-H) phases
2018
Abstract The sorption of actinides (Th, U – Am) was studied in dependence of the solid-to-liquid (S/L) ratio (0.5–20.0 g/L) and the calcium-to-silicon (C:S) ratio. The C:S ratio was varied between 1.80 and 0.70 to simulate the changing composition of the C-S-H phases during cement degradation from high to low C:S ratios. The decrease of the calcium content in the C-S-H phases by time is accompanied by a decrease in pH in the corresponding suspensions from 12.6 to 10.2. X-ray photoelectron spectroscopy (XPS) of the C-S-H phases showed an increasing depletion of Ca on the surface with increasing C:S ratio in comparison to the composition of the solid phase as a whole. The sorption experiments…
Dual-Diameter Laterals in Center-Pivot Irrigation System
2022
Design strategies to enhance modern irrigation practices, reduce energy consumption, and improve water use efficiency and crop yields are fundamental for sustainability. Concerning Center-Pivot Irrigation Systems, different design procedures aimed at optimizing water use efficiency have been proposed. Recently, following a gradually decreasing sprinkler spacing along the pivot lateral with constant diameter and sprinkler flow rate, a new design method providing a uniform water application rate has been introduced. However, no suggestions were given to design multiple-diameter laterals characterized by different values of the inside pipe diameter. In this paper, first the previous design pro…