Search results for "solu"

Iän ja fyysisen aktiivisuuden yhteys supistumisominaisuuksiltaan erityyppisten luustolihasten proteiinien O-GlcNAcylaatioon

2014

The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A

2021

Protein phosphatase 2A (PP2A) activity is critical for maintaining normal physiological cellular functions. PP2A is inhibited by endogenous inhibitor proteins in several pathological conditions including cancer. A PP2A inhibitor protein, ARPP-19, has recently been connected to several human cancer types. Accordingly, the knowledge about ARPP-19—PP2A inhibition mechanism is crucial for the understanding the disease development and the therapeutic targeting of ARPP-19—PP2A. Here, we show the first structural characterization of ARPP-19, and its splice variant ARPP-16 using NMR spectroscopy, and SAXS. The results reveal that both ARPP proteins are intrinsically disordered but contain transient…

Halogens and trace metal emissions from the ongoing 2008 summit eruption of Kīlauea volcano, Hawai`i

2012

Volcanic plume samples taken in 2008 and 2009 from the Halemàumàu eruption at Kīlauea provide new insights into Kīlauea's degassing behaviour. The Cl, F and S gas systematics are consistent with syn-eruptive East Rift Zone measurements suggesting that the new Halemàumàu activity is fed by a convecting magma reservoir shallower than the main summit storage area. Comparison with degassing models suggests that plume halogen and S composition is controlled by very shallow (<3m depth) decompression degassing and progressive loss of volatiles at the surface. Compared to most other global volcanoes, Kīlauea's gases are depleted in Cl with respect to S. Similarly, our Br/S and I/S ratio measurem…

Predicting valuable forest habitats using an indicator species for biodiversity

2020

Intensive management of boreal forests impairs forest biodiversity and species of old-growth forest. Effective measures to support biodiversity require detection of locations valuable for conservation. We applied species distribution models (SDMs) to a species of mature forest, the northern goshawk (Accipiter gentilis, goshawk), that is often associated with hotspots of forest biodiversity. We located optimal sites for the goshawk on a landscape scale, assessed their state under intensified logging operations and identified characteristics of goshawks' nesting sites in boreal forests. Optimal sites for the goshawk covered only 3.4% of the boreal landscape and were mostly located outside pro…

Understanding altered contractile properties in advanced age : insights from a systematic muscle modelling approach

2023

Age-related alterations of skeletal muscle are numerous and present inconsistently, and the effect of their interaction on contractile performance can be nonintuitive. Hill-type muscle models predict muscle force according to well-characterised contractile phenomena. Coupled with simple, yet reasonably realistic activation dynamics, such models consist of parameters that are meaningfully linked to fundamental aspects of muscle excitation and contraction. We aimed to illustrate the utility of a muscle model for elucidating relevant mechanisms and predicting changes in output by simulating the individual and combined effects on isometric force of several known ageing-related adaptations. Simu…

Luurankolihassolun glykolyysin simulointi differentiaaliyhtälöillä

2015

Solun aineenvaihduntaa on hankala tutkia. Simulointi voi olla eräs ratkaisu ongelmaan. Tutkielma tarkastelee differentiaaliyhtälöihin perustuvaa luurankolihaksen glykolyysin simuloimista. Siihen on kehitetty 2000-luvulla glykolyysin reaktioiden empiirisiin mittaustuloksiin perustuvia malleja. Differentiaaliyhtälömallit soveltuvat hyvin simuloimiseen, ja suurinpana ongelmana voidaan pitää parametrien saatavuutta ja epävarmuutta. Cell metabolism is difficult to investigate. Simulation can be one solution to the problem. This thesis examines differential equation based simulation of skeletal muscle glycolysis. For simulation, in 2000s it has been developed models based on empirical measurement…

Viruses are ancient parasites that have influenced the evolution of contemporary and archaic forms of life

2010

Triacylglycerol Analysis in Human Milk and Other Mammalian Species: Small-Scale Sample Preparation, Characterization, and Statistical Classification …

2015

In this work, a method for the separation of triacylglycerols (TAGs) present in human milk and from other mammalian species by reversed-phase high-performance liquid chromatography using a core–shell particle packed column with UV and evaporative light-scattering detectors is described. Under optimal conditions, a mobile phase containing acetonitrile/n-pentanol at 10 °C gave an excellent resolution among more than 50 TAG peaks. A small-scale method for fat extraction in these milks (particularly of interest for human milk samples) using minimal amounts of sample and reagents was also developed. The proposed extraction protocol and the traditional method were compared, giving similar results…

Modelling of rotations by using matrix solutions of nonlinear wave equations

2007

A family of matrix solutions of nonlinear wave equations is extended and its application to modelling is given. It is shown that a similarity transformation, induced by the matrix solution, is equivalent to the rotation. Matrix solutions are used for modelling helical motions and vortex rings, simultaneous rotations and particles collision, mapping contraction and pulsating spheres. Geometrical interpretation of the doubling of rotation angle in each step of sequential mapping contraction is given. First Published Online: 14 Oct 2010

High-resolution, accurate multiple-reflection time-of-flight mass spectrometry for short-lived, exotic nuclei of a few events in their ground and low…

2019

Physical review / C covering nuclear physics 99(6), 064313 (2019). doi:10.1103/PhysRevC.99.064313