Search results for "spectrum"
showing 10 items of 2043 documents
Duloxetine serum concentrations and clinical effects. Data from a therapeutic drug monitoring (TDM) survey.
2009
INTRODUCTION The aim of this study was to relate drug concentrations in serum and clinical effects in patients treated with the new antidepressant duloxetine. METHODS Data were obtained from a newly established therapeutic drug monitoring (TDM) survey. Duloxetine was measured using HPLC with UV detection and clinical effects by the clinical global impressions (CGI) scale for improvement. RESULTS The study included 103 depressed inpatients (69% female). Patients under duloxetine monotherapy who were very much improved according to CGI had significantly (p<0.05) higher serum levels than patients with moderate, minimal or lacking improvement (mean+/-SD and range, 93+/-53 ng/mL and 30-182 ng/mL…
The effect of water on protein dynamics
2004
Neutron diffraction and spectroscopy were applied to describe the hydration and dynamics of a soluble protein and a natural membrane from extreme halophilic Archaea. The quantitative dependence of protein motions on water activity was clearly illustrated, and it was established that a minimum hydration shell is required for the systems to access their functional resilience, i.e. a dynamics state that allows biological activity.
Synthesis of porous indium phosphide with nickel oxide crystallites on the surface
2022
Y. Suchikova, S. Kovachov, I. Bohdanov, І. Bardus show their appreciation to the Ministry of Education and Science of Ukraine for its support, in particular: grant 0122U000129 “Search for Optimal Conditions for the Synthesis of Nanostructures on the Surface of Semiconductors A3B5, A2B6 and Silicon for Photonics and Solar Energy,” and grant 0121U109426 “Theoretical and Methodological Principles of Systemic Fundamentalization of Intended Specialist Training in the Field of Nanophase Materials Science for Productive Professional Activity”.
EUSO Science
2005
EUSO is a mission to explore the extreme universe by the probe of Ultra High Energy Cosmic Rays (LTHECRs) and LTHE neutrinos [1]. EUSO monitors a gigantic volume of atmosphere from Space and measures showers induced by UHECRs and UHE neutrinos. Scientifically, it is important to measure the energy spectrum of UHECRs well beyond GZK energy with high statistics. EUSO ensures the observation of UHECRs up to 10(21) eV even in the case of GZK mechanism working [2-7], and gives us a clear picture of the existence / non-existence of the GZK effect and the behavior of the spectrum beyond GZK energy, which represents the contributions from nearby sources. The anisotropy study of UHECR arrival direct…
Characterization of the first extended-spectrum b-lactamase–producing nontyphoidal Salmonella strains Isolated in Tehran, Iran
2010
The infections caused by Salmonella remain a significant public health problem throughout the world. b-Lactams and fluoroquinolones are generally used to treat invasive Salmonella infections, but emergence and spread of antibiotic-resistant strains are being increasingly notified in many countries. In particular, detection of extended spectrum b-lactamases (ESBLs) in Salmonella spp. is a newly emerging threat worldwide. This study was carried out to characterize b-lactamase–producing Salmonella strains identified in Tehran, Iran. Over the 2-year period from 2007 to 2008, 6 of 136 Salmonella isolates recovered from pediatrics patients, including three Salmonella enterica serotypes Enteritidi…
Novel Munc13-4 mutations in children and young adult patients with haemophagocytic lymphohistiocytosis
2006
Familial haemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous disorder characterised by constitutive defects in cellular cytotoxicity resulting in fever, hepatosplenomegaly and cytopenia, and the outcome is fatal unless treated by chemoimmunotherapy followed by haematopoietic stem‐cell transplantation. Since 1999, mutations in the perforin gene giving rise to this disease have been identified; however, these account only for 40% of cases. Lack of a genetic marker hampers the diagnosis, suitability for transplantation, selection of familial donors, identification of carriers, genetic counselling and prenatal diagnosis. Mutations in the Munc13–4 gene have recently been des…
Comparative study of sensory modulation vulnerabilities in children with and without ASD in family and school contexts
2018
Background: Children with autism spectrum disorder (ASD) may present sensory processing alterations that are specific to each environment in which they develop, inevitably impacting their daily fun...
Remote sensing of chlorophyll fluorescence for estimation of stress in vegetation. Recommendations for future missions
2007
Vegetation monitoring is a key issue in Earth Observation due to its relation with the global CO2 cycle. Chlorophyll fluorescence (ChF) emitted by the vegetation is an accurate indicator of the plant status and their photosynthetic activity. This work analyses the diurnal evolution of the ChF emission spectrum and the fluorescence yield in order to determine the best conditions for remote sensing of ChF from a satellite platform. The ChF evolution is studied at leaf level during several diurnal cycles, in simulated conditions, for two species under different stress conditions. The analysis of the signal levels gives an estimation of the values of ChF emission which could be observed from a …
Polar motion prediction using the combination of SSA and Copula-based analysis
2018
The real-time estimation of polar motion (PM) is needed for the navigation of Earth satellite and interplanetary spacecraft. However, it is impossible to have real-time information due to the complexity of the measurement model and data processing. Various prediction methods have been developed. However, the accuracy of PM prediction is still not satisfactory even for a few days in the future. Therefore, new techniques or a combination of the existing methods need to be investigated for improving the accuracy of the predicted PM. There is a well-introduced method called Copula, and we want to combine it with singular spectrum analysis (SSA) method for PM prediction. In this study, first, we…
When financial economics influences physics: The role of Econophysics
2019
This paper aims at analyzing the unexpected influence of Financial economics on Physics. The rise of Econophysics, a fundamentally new approach in finance, suggests that the influence between the two disciplines becomes less unilateral than in the past. Methodological debates emerging in Econophysics led physicists to acknowledge that dealing with financial complex systems contributed to a wider modelling of their field. The approach of econophysicists suggests that physicists might try to conceptualize physical phenomena by integrating elements they faced with in Financial economics, and more generally in Economics. Surprisingly, many of econophysicists’ argumentations have some methodolog…