Search results for "spinal"

Continuous Theta-Burst Stimulation Intensity Dependently Facilitates Motor-Evoked Potentials Following Focal Electrical Stimulation of the Rat Motor …

2020

Although theta-burst stimulation (TBS) is known to differentially modify motor cortical excitability according to stimulus conditions in humans, whether similar effects can be seen in animals, in particular rats, remains to be defined. Given the importance of experimental rat models for humans, this study explored this stimulation paradigm in rats. Specifically, this study aimed to explore corticospinal excitability after TBS in anesthetized animals to confirm its comparability with human results. Both inhibition-facilitation configurations using paired electrical stimulation protocols and the effects of the TBS paradigm on motor-evoked potentials (MEPs) in rat descending motor pathways wer…

Spinal analgesia for advanced cancer patients: An update

2011

In the nineties, spinal analgesia has been described as an useful means to control pain in advanced cancer patients. The aim of this review was to update this information with a systematic analysis of studies performed in the last 10 years. 27 papers pertinent with the topic selected for review were collected according to selection criteria. Few studies added further information on spinal analgesia in last decade. Despite a lack of a clinical evidence, spinal analgesia with a combination of opioids, principally morphine, and local anesthetics may allow to achieve analgesia in patients who had been intensively treated unsuccessfully with different trials of opioids. Some adjuvant drugs such …

Model Free Control for muscular force by Functional Electrical Stimulation using pulse width modulation

2016

International audience; Functional Electrical Stimulation (FES) is a useful technique for restoring functions for patients with neurological disorders. Muscle activities can be artificially driven through delivery of electrical pulses to skeletal muscles. Typically, muscles are activated by using constant stimulation train with a fixed parameters (amplitude, frequency and pulse width). In addition, the FES systems do not adapt the parameters stimulation to obtain a desired force response during the rehabilitation session. The purpose of this study is to investigate a real-time FES system for adapting automatically the stimulation parameters (stimulation pulse width) to track a desired force…

Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with external ventricular drain

2018

International audience; Background: Due to its antibacterial properties ceftaroline could be attractive for the treatment of bacterial postneurosurgicalmeningitis. However only few data are available concerning its meningeal concentrations. The aim of this studywas to investigate ceftaroline cerebrospinal fluid (CSF) pharmacokinetics (PK) in intensive care unit (ICU) patients with anexternal ventricular drain (EVD).Materials/methods: Patients received a single 600 mg dose of ceftaroline as a one-hour intravenous infusion . Blood and CSFsamples were collected before and 0.5, 1, 3, 6, 12 and 24 hours after the end of the infusion. Concentrations were assayed inplasma and CSF by LC-MS/MS. A tw…

Psychology of spinal cord injured patients

1998

Muscle Function Differences between Patients with Bulbar and Spinal Onset Amyotrophic Lateral Sclerosis. Does It Depend on Peripheral Glucose?

2021

Background: One of the pathogenic mechanisms of ALS disease is perturbed energy metabolism particularly glucose metabolism. Given the substantial difference in the severity and the prognosis of the disease, depending on whether it has a bulbar or spinal onset, the aim of the study was to determine metabolic differences between both types of ALS, as well as the possible relationship with muscle function. Materials and Methods: A descriptive, analytical, quantitative, and transversal study was carried out in hospitals and Primary Care centers in the region of Valencia, Spain. Fasting glucose and alkaline phosphatase (AP) levels in venous blood, muscle percentage, fat percentage, muscle streng…

Problematiche correlate all’utilizzo di anestesia spinale in soggetti esposti ad attività lavorative comportanti “usura” del rachide lombare

2008

Distinct 5' SCL enhancers direct transcription to developing brain, spinal cord, and endothelium: neural expression is mediated by GATA factor bindin…

1999

The SCL gene encodes a basic helix-loop-helix transcription factor with a pivotal role in the development of endothelium and of all hematopoietic lineages. SCL is also expressed in the central nervous system, although its expression pattern has not been examined in detail and its function in neural development is unknown. In this article we present the first analysis of SCL transcriptional regulation in vivo. We have identified three spatially distinct regulatory modules, each of which was both necessary and sufficient to direct reporter gene expression in vivo to three different regions within the normal SCL expression domain, namely, developing endothelium, midbrain, and hindbrain/spinal …

Espectro clínico y genético de las neuropatías hereditarias motoras distales en la Comunidad Valenciana

2022

Las neuropatías hereditarias motoras distales (NHMd) son enfermedades neuromusculares de origen genético que se caracterizan por una degeneración de la parte motora de los nervios periféricos. Se engloban dentro de un grupo más amplio de neuropatías hereditarias llamadas neuropatías tipo Charcot- Marie-Tooth (CMT). Son enfermedades que afectan a gente joven y producen una discapacidad importante. Actualmente no disponemos de tratamiento que modifique el curso de las NHMd, por lo que los esfuerzos en investigación en este grupo de enfermedades son muy importantes. El diagnóstico y el estudio de la historia natural de las diferentes formas de NHMd es complicado porque son enfermedades poco fr…

Neural contribution to postactivation potentiation

2015

The current study was designed to investigate the contribution of neural factors to postactivation potentiation (PAP). Neuromuscular function (i.e. twitches, H-reflexes, motor evoked potentials, and voluntary isometric ballistic contractions) of 8 power-trained (POW) and 8 endurance-trained (END) athletes was recorded before and after a 8-second maximal isometric conditioning contraction (CC) to induce PAP, to elucidate discriminating neural factors in exploiting PAP that might arise from the former training background compared to the latter. After CC, twitch peak force and rate of force development were significantly increased, with higher potentiation in POW (29 ± 11% and 64 ± 24%) than E…