Search results for "stance"
showing 10 items of 7708 documents
Internetbezogene Störungen: Wo kann Prävention ansetzen?
2020
Zusammenfassung Internetbezogene Störungen umfassen unterschiedliche Onlineaktivitäten, die exzessiv entgleiten, das Leben Betroffener dominieren und zu nachhaltigen negativen Folgen führen können. Da internetbezogene Störungen einen chronischen Verlauf nehmen und eine erhöhte psychopathologische Symptombelastung bedingen können, sind wirksame Interventionsprogramme und evaluierte Präventionsangebote dringend notwendig.
¿Por qué (también) es tan difícil legislar sobre juego en España? Un ‘déjà vu’ de lo ocurrido con el alcohol
2016
Regular el juego para prevenir la adicción: hoy más necesario que nunca
2016
En mayo de 2013 aparecio la quinta edicion de la clasificacion de los trastornos mentales (DSM-5) de la American Psychiatric Association (APA, 2013), en la cual se incluye el trastorno de juego dentro de la categoria de trastornos adictivos, que es algo que era demandado desde hace decadas desde los ambitos clinicos, sociales y cientificos. El juego de azar, que segun la propia APA tiene la misma consideracion que las drogas o el alcohol en cuanto a la activacion de los circuitos cerebrales de recompensa y a las consecuencias clinicas del trastorno del juego, no tiene, sin embargo, esa consideracion desde el principal ambito desde donde se debe llevar a cabo la prevencion de la adiccion, qu…
Evaluación de la adaptación de los ítems de consumo del AUDIT para mejor el cribado de Binge Drinking en universitarios
2019
The strong presence of Binge Drinking (BD) amongst university students, as well as the consequences associated with the same and the changes taking place over recent years regarding its conceptualization make it necessary to examine the usefulness of screening instruments used to detect this drinking pattern. This study examines the usefulness of a briefer adaptation of the AUDIT proposed by Cortes, Gimenez, Motos, and Sancerni (2017a). College students self-administered the AUDIT, the revised items 2 and 3 (A2r and A3r), and completed a weekly self-report of their alcohol intake. BD was classified according to the amount consumed and the frequency of that consumption over the past six mont…
Estrés y drogadicción: una perspectiva actualizada para 2020
2020
The role of stress in addiction is complex. In this editorial we highlight the main issues of interest in the ongoing research in relation to drug addiction and stress from an up-to-date perspective. Thus, taking into account that several bibliographic reviews have been published recently on the subject, the aim of this editorial has been to gather updated information in order to point out future directions of research that could make a valuable contribution to the knowledge about addictions and the role that stress plays in them. Finally, we stress the need for interdisciplinary research that addresses stress and addictions by incorporating and integrating physical and psychosocial facto…
Système endocannabinoïde : effets sur le métabolisme glucidique, mais aussi lipidique
2016
Resume Le systeme endocannabinoide (SEC) est compose de recepteurs couples aux proteines G : Cannabinoid type 1-receptor (CB 1 -R) et Cannabinoid type 2-receptor (CB 2 -R), de leurs ligands endogenes (anandamide [AEA], et 2-acylglycerol [2-AG]), et des enzymes responsables de leur synthese et de leur degradation. Bien que les recepteurs CB 1 -R et CB 2 -R furent initialement decrits au niveau du systeme nerveux central, ils sont presents dans de nombreux tissus peripheriques, ou ils sont impliques dans le metabolisme, la croissance, et l’inflammation. Apres le retrait commercial du rimonabant, pour des effets secondaires psychiatriques, un agoniste inverse du recepteur CB 1 (CB 1 -R), desti…
Betulinic Acid Exerts Cytotoxic Activity Against Multidrug-Resistant Tumor Cells via Targeting Autocrine Motility Factor Receptor (AMFR).
2018
Betulinic acid (BetA) is a naturally occurring pentacyclic triterpene isolated from the outer bark of white-barked birch trees and many other medicinal plants. Here, we studied betulinic acid's cytotoxic activity against drug-resistant tumor cell lines. P-glycoprotein (MDR1/ABCB1) and BCRP (ABCG2) are known ATP-binding cassette (ABC) drug transporters that mediating MDR. ABCB5 is a close relative to ABCB1, which also mediates MDR. Constitutive activation of the EGF receptor is tightly linked to the development of chemotherapeutic resistance. BetA inhibited P-gp, BCRP, ABCB5 and mutation activated EGFR overexpressing cells with similar efficacy as their drug-sensitive parental counterparts. …
Anti-Listeria activity of lactic acid bacteria in two traditional Sicilian cheeses
2017
<em>Listeria monocytogenes</em> is a pathogen frequently found in dairy products, and its growth is difficult to control. Bacteriocinlike inhibitory substances (BLIS), produced by lactic acid bacteria (LAB), having proven <em>in vitro</em> anti-<em>Listeria</em> activity, could provide an innovative approach to control <em>L. monocytogenes</em>; however, this application needs to be evaluated <em>in vivo</em>. In this study, twenty LAB strains isolated from different Sicilian dairy environments were tested for control of growth of <em>L. monocytogenes</em> in three different experimental trials. First, raw and UHT milk …
Genomic characterization of a local epidemic Pseudomonas aeruginosa reveals specific features of the widespread clone ST395
2017
International audience; Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen with several clones being frequently associated with outbreaks in hospital settings. ST395 is among these so-called 'international' clones. We aimed here to define the biological features that could have helped the implantation and spread of the clone ST395 in hospital settings. The complete genome of a multidrug resistant index isolate (DHS01) of a large hospital outbreak was analysed. We identified DHS01-specific genetic elements, among which were identified those shared with a panel of six independent ST395 isolates responsible for outbreaks in other hospitals. DHS01 has the fifth largest chromosome of …
Constitutive activation of MexT by amino acid substitutions results in MexEF-OprN overproduction in clinical isolates of Pseudomonas aeruginosa
2018
ABSTRACT When overproduced, the multidrug efflux system MexEF-OprN increases the resistance of Pseudomonas aeruginosa to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in the regulatory gene mexT result in oligomerization of the LysR regulator MexT, constitutive upregulation of the efflux pump, and increased resistance in clinical isolates.