Constitutive activation of MexT by amino acid substitutions results in MexEF-OprN overproduction in clinical isolates of Pseudomonas aeruginosa

6533b7d2fe1ef96bd125f68e

RESEARCH PRODUCT

Constitutive activation of MexT by amino acid substitutions results in MexEF-OprN overproduction in clinical isolates of Pseudomonas aeruginosa

Patrick Plésiat Catherine Llanes Christophe Bordi Isabelle Broutin Paulo Juarez

subject

0301 basic medicine 030106 microbiology Microbial Sensitivity Tests [ SDV.MP.BAC ] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology medicine.disease_cause Microbiology 03 medical and health sciences Antibiotic resistance Downregulation and upregulation Mechanisms of Resistance [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology Drug Resistance Bacterial medicine Pharmacology (medical)Overproduction ComputingMilieux_MISCELLANEOUS Regulator gene Pharmacology chemistry.chemical_classification Chemistry Pseudomonas aeruginosa Chloramphenicol Gene Expression Regulation Bacterial [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology 3. Good health Amino acid Anti-Bacterial Agents Infectious Diseases [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Amino Acid Substitution Mutation Pseudomonas aeruginosa Efflux medicine.drug

description

ABSTRACT When overproduced, the multidrug efflux system MexEF-OprN increases the resistance of Pseudomonas aeruginosa to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in the regulatory gene mexT result in oligomerization of the LysR regulator MexT, constitutive upregulation of the efflux pump, and increased resistance in clinical isolates.

year	journal	country	edition	language
2018-03-01

https://hal-amu.archives-ouvertes.fr/hal-01770232

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