Search results for "steady state"
showing 10 items of 173 documents
A generalized Degn–Harrison reaction–diffusion system: Asymptotic stability and non-existence results
2021
Abstract In this paper we study the Degn–Harrison system with a generalized reaction term. Once proved the global existence and boundedness of a unique solution, we address the asymptotic behavior of the system. The conditions for the global asymptotic stability of the steady state solution are derived using the appropriate techniques based on the eigen-analysis, the Poincare–Bendixson theorem and the direct Lyapunov method. Numerical simulations are also shown to corroborate the asymptotic stability predictions. Moreover, we determine the constraints on the size of the reactor and the diffusion coefficient such that the system does not admit non-constant positive steady state solutions.
18F-labeling and evaluation of novel MDL 100907 derivatives as potential 5-HT2A antagonists for molecular imaging.
2009
Abstract Introduction The serotonergic system, especially the 5-HT2A receptor, is involved in various diseases and conditions. It is a very interesting target for medicinal applications. Methods Two novel 5-HT2A tracers, namely, [ 18 F]DD-1 and the enantiomeric pure ( R )-[ 18 F]MH.MZ, were radiolabeled by 18 F-fluoroalkylation of the corresponding desmethyl analogue. In vitro binding autoradiography on rat brain slices was performed to test the affinity and selectivity of these tracers. Moreover, first μPET experiments of ( R )-[ 18 F]MH.MZ were carried out in Sprague-Dawley rats. Results [ 18 F]DD-1 ( K i =3.23 nM) and ( R )-[ 18 F]MH.MZ ( K i =0.72 nM) were 18 F-fluoroalkylated by the se…
Dynamics of ketone body metabolism in diabetic rats.
1972
Steady state blood levels of ketone bodies during infusions of acetoacetate at various rates have been compared in healthy and diabetic rats. The characteristics of the metabolic elimination of ketone bodies from the blood are completely changed in diabetic rats. Whereas steady state levels of ketone bodies increase linearly with the infusion rate in healthy rats, this increase is exponential in diabetic animals. This difference, which is due to an impaired metabolic elimination, becomes evident only above a dosage of 50 μmoles acetoacetate per kg per min. Chronic treatment with insulin for 4–6 days, but not acute insulin injection, restores the capacity of diabetic rats to metabolize keton…
Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: Lessons from the DAL…
2014
The aims of this study were to describe the variability in protein binding of teicoplanin in critically ill patients as well as the number of patients achieving therapeutic target concentrations. This report is part of the multinational pharmacokinetic DALI Study. Patients were sampled on a single day, with blood samples taken both at the midpoint and the end of the dosing interval. Total and unbound teicoplanin concentrations were assayed using validated chromatographic methods. The lower therapeutic range of teicoplanin was defined as total trough concentrations from 10 to 20 mg/L and the higher range as 10-30 mg/L. Thirteen critically ill patients were available for analysis. The followi…
Analysis of the thermo-mechanical behaviour of the DEMO Water-Cooled Lithium Lead breeding blanket module under normal operation steady state conditi…
2015
Within the framework of DEMO R&D activities, a research cooperation has been launched between ENEA, the University of Palermo and CEA to investigate the thermo-mechanical behaviour of the outboard equatorial module of the DEMO1 Water-Cooled Lithium Lead (WCLL) blanket under normal operation steady state scenario. The research campaign has been carried out following a theoretical-computational approach based on the Finite Element Method (FEM) and adopting a qualified commercial FEM code. In particular, two different 3D FEM models (Model 1 and Model 2), reproducing respectively the central and the lateral poloidal-radial slices of the WCLL blanket module, have been set up. A particular attent…
Synthetic nanopores with fixed charges: An electrodiffusion model for ionic transport
2003
Synthetic nanopores with fixed charges exhibit ionic equilibrium and transport properties that resemble those displayed by biological ion channels. We present an electrodiffusion model based on the Nernst-Planck flux equations, which allows for a qualitative description of the steady state ionic transport through a nanopore when the membrane fixed charges and all mobile carriers (including the water ions) are properly taken into account. In particular, we study the current-voltage curve, the electrical conductance, the reversal potential (a measure of the nanopore ionic selectivity), as well as the flux inhibition by protons and divalent cations in the nanopore. The model clearly shows how …
Thermo-mechanical analyses and ways of optimization of the helium cooled DEMO First Wall under RCC-MRx rules
2017
Abstract The EUROfusion Consortium develops a design of a fusion power demonstrator plant (DEMO) in the framework of the European “Horizon 2020” innovation and research program. One of the key components in the fusion reactor is the Breeding Blanket (BB) surrounding the plasma, ensuring tritium self-sufficiency, heat removal for conversion into electricity, and neutron shielding. Among the 4 candidates for the DEMO BB, 2 of them use helium as coolant (HCPB, HCLL), and another one (DCLL) uses helium to cool down the First Wall (FW) only. Due to uncertainties regarding the plasma Heat Flux (HF) load the DEMO BB integrated FW will have to cope with, a set of sensitive thermal and stress analys…
Influence on PD Parameters due to Voltage Conducted Disturbances
2004
In the standard specification of ac dielectric-characteristic measurements of insulating materials, test voltage is prescribed as "approximately sinusoidal" when the highest acceptable deviation of the HV waveform, from the correct sinusoidal shape, is limited to a /spl plusmn/5% tolerance range of the crest factor value. In the field of partial discharge (PD) measurements and their statistical data processing, on which forecasts of long term behavior of components and their reliability are currently carried out, the results of elaborations depend on the voltage wave shape. In this paper, the errors in PD measurements, evaluated at industrial frequencies, due to applied voltages distorted b…
Steady State Counterbalance Valve Modeling with the Influence of Synthetic Ester Oils Using CFD
2020
This study looks in details at the effects of synthetic esters being applied to a counterbalance valve from the perspective of a system engineer. There is limited literature on the subject of applied synthetic esters and as such limited unbiased sources for information. This creates reluctance against the use of these fluids in sectors and regions with no prior experience and knowledge of what to expect. This study expands the applied literature by investigating a commercially available valve using commercial oils, a basic synthetic ester, a fully saturated synthetic ester and a typical mineral oil type for benchmarking. The investigation is based on both computational fluid dynamics and ex…
Heterogeneous and Homogeneous Diffusivity in an Ion-Conducting Glass
1999
The nature of ion diffusivity in the vitreous conductor 2Ca NO3 2 ? 3KNO3 (CKN) was studied by nonresonant dielectric hole burning. Spectral holes in the electric field relaxation are probed subsequent to a high electric sinusoidal burn field. For sufficiently high pump frequencies we are able to induce spectrally selective modifications in the relaxation of the electric modulus, indicating that ionic diffusivity is a spatially varying quantity in glassy CKN. Homogeneous behavior occurs in the regime of low pump frequencies, in which the resistivity approaches its steady state value. Thus, longer-ranged ionic motions lead to a spatial averaging over the heterogeneity of local ion diffusivit…