Search results for "structural"
showing 10 items of 5047 documents
An improvement of ComiR algorithm for microRNA target prediction by exploiting coding region sequences of mRNAs
2020
AbstractMicroRNA are small non-coding RNAs that post-transcriptionally regulate the expression levels of messenger RNAs. MicroRNA regulation activity depends on the recognition of binding sites located on mRNA molecules. ComiR is a web tool realized to predict the targets of a set of microRNAs, starting from their expression profile. ComiR was trained with the information regarding binding sites in the 3’utr region, by using a reliable dataset containing the targets of endogenously expressed microRNA in D. melanogaster S2 cells. This dataset was obtained by comparing the results from two different experimental approaches, i.e., inhibition, and immunoprecipitation of the AGO1 protein--a comp…
Social suffering as structural and symbolic violence. LGBT experiences in the Face of AIDS film archive
2018
The chapter aims to summarize the main sociological approaches that acknowledge the link that exists between AIDS and the stigmatization of nonnormative sexual conducts and then we will address the issue of structural violence and how it can be discerned in the impact of HIV/AIDS on oppressed and marginalized groups on a global scale, as manifested in the Face of AIDS film archive.
Firefly Algorithm for Structural Optimization Using ANSYS
2021
In the mid-1980s, several metaheuristic methods began to be developed for solving a very large class of computational problems with the aim of obtaining more robust and efficient procedures. Among them, many metaheuristic methods use bio-inspired intelligent algorithms. In recent years, these methods are becoming increasingly important and they can be used in various subject areas for solving complex problems. Firefly Algorithm is a nature-inspired optimization algorithm proposed by Yang to solve multimodal optimization problems. In particular, the method is inspired by the nature of fireflies to emit a light signal to attract other individuals of this species. In this work, a numerical stu…
Inducible ASABF-Type Antimicrobial Peptide from the Sponge Suberites domuncula: Microbicidal and Hemolytic Activity in Vitro and Toxic Effect on Moll…
2011
Since sponges, as typical filter-feeders, are exposed to a high load of attacking prokaryotic and eukaryotic organisms, they are armed with a wide arsenal of antimicrobial/cytostatic low-molecular-weight, non-proteinaceous bioactive compounds. Here we present the first sponge agent belonging to the group of ASABF-type antimicrobial peptides. The ASABF gene was identified and cloned from the demospongeSuberites domuncula. The mature peptide, with a length of 64 aa residues has a predicted pI of 9.24, and comprises the characteristic CSαβ structural motif. Consequently, the S. domuncula ASABF shares high similarity with the nematode ASABFs ; it is distantly related to the defensins. The recom…
Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics
2021
Graphical abstract
Audiovisual time-to-collision estimation for accelerating vehicles: The acoustic signature of electric vehicles impairs pedestrians' judgments
2022
To avoid collisions, pedestrians intending to cross a road need to accurately estimate the time-to-collision (TTC) of an approaching vehicle. For TTC estimation, auditory information can be considered particularly relevant when the approaching vehicle accelerates. The sound of vehicles with internal combustion engine (ICEVs) provides characteristic auditory information about the acceleration state (increasing speed and engine load). However, for electric vehicles (EVs), the acoustic signature during acceleration is less salient. Although the auditory detection of EVs has been studied extensively, there is no research on potential effects of the altered acoustic signature of EVs on TTC estim…
Synthesis, structural diversity, inter-conversion and reactivity of Cu(II) complexes of hydroxy-rich molecules
2002
Tetranuclear Cu(II) complexes having linear, cubane and pseudodouble-cubane cores were synthesized using hydroxy-rich molecules possessing amine and imine groups. The products were structurally characterized and were studied for their ability to oxidize catechol as well as for their inter-conversion between mono- and tetra-nuclear complexes.
Structural, magnetic and electronic characterization of an isostructural series of dinuclear complexes of 3d metal ions bridged by tpbd
2013
Abstract Dinuclear complexes of the type [{M(H2O)(phen)}2(μ-tpbd)](ClO4)4 with N,N,N′,N′-Tetrakis-(2-pyridylmethyl)-benzene-1,4-diamine (tpbd) as bridging ligand and M = Mn(II) (1), Fe(II) (2), Co(II) (3), Ni(II) (4), Cu(II) (5), Zn(II) (6) were synthesized, structurally analyzed and their magnetic as well as their electrochemical properties are determined. A ligand-centered one-electron oxidation leads to radical complexes for which the lifetimes are strongly dependent on the coordinated metal ion as followed from time-resolved UV–Vis absorption spectroscopy. In addition to the six homometallic dinuclear complexes, one analog heterometallic Mn(II)/Ni(II) compound (7) of the same constituti…
INVESTIGATING OLDER ADULTS’ INTENTION TO USE SMARTPHONES WITH A STRUCTURAL EQUATION MODELING APPROACH
2018
Although the uptake of smartphones amongst older adults has recently taken off, the proportion of feature phone users in this population group is still prevailing. Thus, drawing on the senior technology acceptance model (STAM) and the diffusion of innovation theory (DIT) this study aimed to investigate what personal and contextual factors affect the adoption of smartphones among older adults. A telephone survey on a nation-wide representative sample of older adults aged 55+ (n = 1581) was conducted, measuring eight STAM and DIT factors (e.g., perceived usefulness, resistance to change, mobile phone anxiety) of behavioral intention to use smartphones. Using confirmatory factor analysis and s…
Appetite for destruction: A psychometric examination and prevalence estimation of destructive leadership in Sweden
2021
There is a growing awareness that destructive leadership has a significant negative impact on employe outcomes. However, little is known about the content and dimensionality of this multidimensional concept, and there are few reliable measures available for organizations and researchers to evaluate these behaviors. Based on a representative sample (N = 1132) of the Swedish workforce, the aim of this study is threefold: first, to examine the factor structure and validity of an easy-to-use multidimensional destructive leadership measure (Destrudo-L)in the general Swedish work context; second, to identify destructive leadership profiles using latent profile analysis (LPA), and determine in wha…