Search results for "structural"
showing 10 items of 5047 documents
High-affinity and selective detection of pyrophosphate in water by a resorcinarene salt receptor
2017
N-Alkyl ammonium resorcinarenes selectively bind pyrophosphate in pure water with an exceptionally high binding constant of up to 1.60 × 107 M–1, three orders of magnitude higher than ATP.
RAB18 Loss Interferes With Lipid Droplet Catabolism and Provokes Autophagy Network Adaptations
2020
Autophagy is dependent on appropriate lipid supply for autophagosome formation. The regulation of lipid acquisition and the autophagy network response to lipid-limiting conditions are mostly elusive. Here, we show that the knockout of the RAB GTPase RAB18 interferes with lipid droplet catabolism, causing an impaired fatty acid release. The resulting reduced lipid-droplet-derived lipid availability influences autophagy and provokes adaptive modifications of the autophagy network. These adjustments include increased expression and phosphorylation of ATG2B as well as augmented formation of the ATG12-ATG5 conjugate. Moreover, ATG9A shows an enhanced phosphorylation at amino acid residues tyrosi…
Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3
2004
The anti-viral type I interferon (IFN) response is initiated by the immediate induction of IFN beta, which is mainly controlled by the IFN-regulatory factor-3 (IRF-3). The signaling pathways mediating viral IRF-3 activation are only poorly defined. We show that the Rho GTPase Rac1 is activated upon virus infection and controls IRF-3 phosphorylation and activity. Inhibition of Rac1 leads to reduced IFN beta promoter activity and to enhanced virus production. As a downstream mediator of Rac signaling towards IRF-3, we have identified the kinase p21-activated kinase (PAK1). Furthermore, both Rac1 and PAK1 regulate the recently described IRF-3 activators, I kappa B kinase- and TANK-binding kina…
Fra le reti e la città. Lo spazio delle nuove stazioni per l'Alta Velocità
2014
Between networks and cities: Architectural space in the new High-Speed train stations. Over the past thirty years, megainvestment rail projects in Western Europe have become powerful transformation vectors. An extensive literature addresses the issue with an urban engineering oriented approach, concerned primarily with the large scale and focusing on governance and urban planning. This monograph section of “Trasporti & Cultura” examines the relationship of new high-speed railroad stations to their cities. The objective is to investigate the depth and meaning of the transformations being wrought by the new stations, in a comparative international scenario. Articles on Japan and China are fol…
STRUCTURAL OPTIMIZATION AND STRUCTURAL ANALYSIS OF COMPOSITE MATERIAL PANEL FOR NAVAL USE
2008
The purpose of the work is the realization of a composite material with long glass fibers having better characteristic than a fiber random composite, to permit the reduction of weight and costs to shipyards for pleasure craft. Structural optimization is performed by ANSYS for the choice of the layers disposition to obtain the maximum stiffness with minimum material employment, saving weight. The study is centered on the research of the better configurations of plies packing in relation of pure shear stress for four different plies. Unidirectional plies, both symmetric orthotropic and symmetric non-orthotropic ones, are realized successively by the vacuum bag technique. Experimental tests of…
Biological and Proteomic Characterization of the Anti-Cancer Potency of Aqueous Extracts from Cell-Free Coelomic Fluid of Arbacia lixula Sea Urchin i…
2022
Echinoderms are an acknowledged source of bioactive compounds exerting various beneficial effects on human health. Here, we examined the potential in vitro anti-hepatocarcinoma effects of aqueous extracts of the cell-free coelomic fluid obtained from the sea urchin Arbacia lixula using the HepG2 cell line as a model system. This was accomplished by employing a combination of colorimetric, microscopic and flow cytometric assays to determine cell viability, cell cycle distribution, the possible onset of apoptosis, the accumulation rate of acidic vesicular organelles, mitochondrial polarization, cell redox state and cell locomotory ability. The obtained data show that exposed HepG2 cells under…
The proposal to transform an old limestone quarry into a botanical garden with a rainforest zone: a case study
2019
Nowadays, a significant part of cities is tackling the problems with post-mining areas. This manuscript is an original research which shows possibilities of their reclamation. The aim of the article is to present the proposal of developing the closed limestone quarry and creating a botanical garden. The proposed spatial solutions allow for creating a new, tourist and recreation space, maintaining the natural heritage. The work also assumed carrying out a dendrological inventory, in order to determine the existing dendrofl ora. The required spatial, nature and communication analyses, which illustrate the current condition of the area and defi ne further design works, have also been carried o…
Influence of brand image of a sports event on the recommendation of its participants
2020
The aim of this research is to test the psychometric properties and relationships of a model where, from brand congruence of a sport event, trust and commitment to it can be generated, influencing future behavior of participants and resulting in a higher recommendation also called Word of Mouth (hereinafter WOM). A quantitative approach has been carried out by means of a validated questionnaire with Likert-type responses, and data were analyzed with the EQS 6.4 software. The findings indicated that the model is adequate, and also confirm that from congruence, we can explain, at a theoretical level, 45% of trust, and in the same way, from the congruence and trust, we can explain 67% of the c…
On the degree of binder activity of reclaimed asphalt and degree of blending with recycling agents
2020
It is common practice to assume full blending of the aged binder of reclaimed asphalt (RA) within the design of new asphalt mixtures. Although being practical, this assumption has often led designers to asphalt mixtures lacking binder. Hence, going towards recycled asphalt mixtures (RAM) there is a need to have a better understanding of the blending phenomena, to have a general agreement on terminology and finally adapting RA classification and mix design procedures accordingly. This manuscript aims at being both a reference and stimulus for the scientific community to work in this direction and on this basis provides a nomenclature and a theoretical framework of the blending phenomena. The…