Search results for "sun"
showing 10 items of 935 documents
Targeted Therapy in Gastrointestinal Stromal Tumors
2015
Advances in the understanding of the molecular mechanisms of gastrointestinal stromal tumors (GISTs) pathogenesis have resulted in the development of a treatment approach which has become a model of targeted therapy in oncology. The introduction of imatinib mesylate [inhibiting KIT/PDGFRA (platelet-derived growth factor receptor-α) and their downstream signaling cascade] has dramatically improved the therapy of advanced (inoperable and/or metastatic) GIST. Imatinib has now become the standard of care in the treatment of patients with advanced GIST and its efficacy has been proven also in adjuvant setting after resection of primary high-risk tumors. However, a majority of patients eventually…
Application of a genetic algorithm in calibration of traffic microsimulation models
2017
This chapter describes the genetic algorithm-based calibration procedure for a microscopic traffic simulation model focusing on freeways and modern roundabouts. For both case studies, the genetic algorithm tool in MATLAB® was applied in order to reach the convergence between the outputs from Aimsun microscopic simulator and the observed data. The automatic interaction with Aimsun software was implemented through an original external Python script. Results showed that the genetic algorithm-based calibration procedure gave a better match to the observed data than simple manual calibration and the efficiency of the calibration efforts resulted significantly improved. At last, the calbrated mod…
Scheda IV.18, argentiere palermitano del 1757, console Giovanni Costanza, calice, argento sbalzato e cesellato, Alcamo (TP), Museo d'Arte Sacra della…
2011
Scheda storico-artistica del calice di maestranza palermitana e vidimato dal console Giovanni Costanza in carica nel 1757. La suppellettile è custodita nel Museo d'Arte Sacra della Basilica Santa Maria Assunta di Alcamo.
Scheda IV.16, argentiere palermitano del 1755, console Antonino Pensallorto, calice, argento dorato sbalzato e cesellato, Alcamo (TP), Museo d'Arte S…
2011
Scheda storico-artistica di un calice di maestranza palermitana e vidimato dal console Antonino Pensallorto in carica nel 1755. L'opera è custodita nel Museo d'Arte Sacra della Basilica Santa Maria Assunta di Alcamo.
Scheda IV.19, argentiere siciliano della metà del XVIII secolo, calice, argento sbalzato e cesellato, Alcamo (TP), Museo d'Arte Sacra della Basilica …
2011
Scheda storico-artistica del calice realizzato da maestranze siciliane della metà del XVIII secolo. L'opera è custodita nel Museo d'Arte Sacra della Basilica Santa Maria Assunta di Alcamo.
Cambio d’appalto e mancata riassunzione del lavoratore detenuto
2023
L'articolo esamina la disciplina delle clausole sociali di riassunzione in materia di cambio d'appalto
Synthesis and biological evaluation of antimalarial and antileukemic activity of new C-10 modified artemisinin derivatives
2021
Abstract Several non-acetal artemisinin derivatives were synthesized and their antimalarial activity against chloroquine-resistant parasites as well as their antileukemic activity were investigated. The azide 10 was proved to have slightly better activity than the current antimalarial drugs such as artesunate and chloroquine. In addition, the azide 10 and the aldehyde 7 were found to be effective in decreasing cell proliferation in leukemia cells.
Determination of unsaturation grade and trans isomers generated during thermal oxidation of edible oils and fats by FTIR
1999
Abstract The oxidative deterioration of culinary oils and fats during episodes of heating associated with normal usage (80°C–300°C, 20–40 min) was monitored by FTIR spectroscopy. The thermal oxidation of polyunsaturated fatty acids during heating was studied by the determination of unsaturation percentage and trans isomers at various temperatures and heating times. Oils frequently used in food frying such as olive oil, sunflower oil, corn oil and seeds oil (sunflower, safflower and canola seed), and lard were studied. The Absorbance Correction Method is proposed to correct the spectral interference and allows the analytic use of signal which would not be initially valid for quantitative ana…
Analytical evaluation of polyunsaturated fatty acids degradation during thermal oxidation of edible oils by Fourier transform infrared spectroscopy
1998
The oxidative deterioration of polyunsaturated fatty acids (PUFAs) in culinary oils and fats during episodes of heating associated with normal usage (80-300 degrees C, 20-40 min) has been monitored by Fourier transform infrared spectroscopy (FTIR). The thermal oxidation of PUFAs is a free radical chain reaction, in which hydroperoxides are generally recognized as the primary major products. Hydroperoxides of PUFAs are easily decomposed into a very complex mixture of secondary products with the decrease in unsaturation. The oxidative advance of PUFAs during heating was studied by the determination of unsaturation percentage at different temperatures and heating times. Oils frequently used in…
Asymmetrische Hetero-Diels-Alder-Reaktionen in wäßriger Lösung unter Verwendung von Aminosäureestern als chiralen Auxiliaren
1989
(R)- und (S)-Aminosaure-methylester-hydrochloride bilden mit Formaldehyd in THF/Wasser-Gemischen Iminium-Ionen, die als elektronenarme Dienophile mit Cyclopentadien, 1,3-Cyclohexadien und Alkyl-substituierten Butadienen bereits bei 0°C Hetero-Diels-Alder-Reaktionen eingehen. Die Cycloaddukte werden mit hohen Ausbeuten im Multigrammasstab und mit Diastereomerenverhaltnissen (bis zu 93:7) gebildet, die mit anderen chiralen Aminen bisher nicht erreicht werden konnten. Mit Hilfe von NOE-Experimenten werden die absoluten Konfigurationen der Hauptdiastereomeren zugeordnet. Aus den Phenylglycin- und den Serin-Derivaten konnen die chiralen Hilfsgruppen mittels hydrogenolytischer Methoden bzw. unter…