Search results for "switch."

An international, phase 3, switchover study of reveglucosidase alfa (BMN 701) in subjects with late-onset Pompe disease

2015

Nanocarrier based on halloysite and fluorescent probe for intracellular delivery of peptide nucleic acids

2022

The development of systems able to deliver genetic material into a target site is a challenge for modern medicine. Single-stranded peptide nucleic acids have attracted attention as promising therapeutic molecules for diagnostic and gene therapy. However, their poor cell membrane permeability represents a drawback for biomedical applications. Halloysite nanotubes (HNTs) are emerging materials in drug delivery applications both for their ability to penetrate cell membranes and for enhancing the solubility of drugs in biological media. Herein, we report the first example of the use of a nanocarrier based on halloysite labelled with fluorescent switchable halochromic oxazine molecules, to deliv…

Regulation of Phenotypic Switching and Heterogeneity in Photorhabdus luminescens Cell Populations.

2019

Phenotypic heterogeneity in bacterial cell populations allows genetically identical organisms to different behavior under similar environmental conditions. The Gram-negative bacterium Photorhabdus luminescens is an excellent organism to study phenotypic heterogeneity since their life cycle involves a symbiotic interaction with soil nematodes as well as a pathogenic association with insect larvae. Phenotypic heterogeneity is highly distinct in P. luminescens. The bacteria exist in two phenotypic forms that differ in various morphologic and phenotypic traits and are therefore distinguished as primary (1°) and secondary (2°) cells. The 1 cells are bioluminescent, pigmented, produce several sec…

Optical switches with biplanemers obtained by intramolecular photocycloaddition reactions of tethered arenes.

2012

The dimerization of anthracene by a [4π + 4π] cycloaddition is one of the oldest and best known reactions in photochemistry. In the series of tethered bichromophoric arenes, this reaction type could be extended to anthracene–naphthalene, naphthalene–naphthalene and recently even to anthracene–benzene and naphthalene–benzene systems. Cyclophanes, which can be regarded as twofold or multiple tethered systems, are not discussed here. The cycloisomerizations are performed by irradiation at the long-wavelength absorption (λ > 270 nm), whereas shorter wavelengths (λ < 270 nm) lead to cycloreversions, which can be also achieved by a thermal route. The systems represent therefore a P- and T-type ph…

ChemInform Abstract: Optical Switches with Biplanemers Obtained by Intramolecular Photocycloaddition Reactions of Tethered Arenes

2013

The dimerization of anthracene by a [4π + 4π] cycloaddition is one of the oldest and best known reactions in photochemistry. In the series of tethered bichromophoric arenes, this reaction type could be extended to anthracene–naphthalene, naphthalene–naphthalene and recently even to anthracene–benzene and naphthalene–benzene systems. Cyclophanes, which can be regarded as twofold or multiple tethered systems, are not discussed here. The cycloisomerizations are performed by irradiation at the long-wavelength absorption (λ > 270 nm), whereas shorter wavelengths (λ < 270 nm) lead to cycloreversions, which can be also achieved by a thermal route. The systems represent therefore a P- and T-type ph…

Trans-to-cis photoisomerization of cyclocurcumin in different environments rationalized by computational photochemistry

2020

International audience; Cyclocurcumin is a turmeric component that attracted much less attention compared to the well known curcumin. In spite of the less deep charcaterization of its properties, cyclocurcumin has shown promising anticancer effects when used in combination with curcumin. Especially, due to its peculiar molecular structure, cyclocurcumin can be regarded as an almost ideal photoswitch, whose capabilities can also be exploited for relevant biological applications. Here, by means of state-of-the-art computational methods for electronic excited-state calculations (TD-DFT, MS-CASPT2, XMS-CASPT2) we analyze in detail the absorption and photoisomerization pathways leading from the …

Optical Bistability and Switching in Oppositely Directed Coupler

2016

We report the optical bistability in two core oppositely directed coupler with negative index material channel. Using Langrangian variational method and Jacobi elliptic functions, we construct the solutions of the coupled nonlinear Schrodinger equations. The bistability arises due to the effective feedback mechanism as a result of opposite directionality of the phase velocity and energy flow in the negative index material channel. We report the various ways to control and manipulate the bistability threshold and hysteresis loop, which could be useful in the design and development of fast and low-threshold optical switches.

Exciton, biexciton and trion recombination dynamics in a single quantum dot under selective optical pumping

2008

Continuous wave- and time-resolved micro-photoluminescence spectroscopy has been performed on single InAs self-assembled quantum dots grown on GaAs. The presence of residual impurities (donors and acceptors) in samples with low dot density opens the possibility to switch from trion to neutral exciton states inside quantum dots by selective optical pumping. We propose a microstate model to describe the recombination dynamics of all the excitonic especies (neutral exciton, positive/negative trion and biexciton) under the considered optical pumping conditions when increasing the excitation power. © 2007 Elsevier B.V. All rights reserved.

Influence of light polarization on the dynamics of optically pumped lasers.

1990

The dynamic behavior of a coherently pumped ring laser with a homogeneously broadened four-level medium is analyzed theoretically, considering linearly polarized pump and generated laser beams. The laser is shown to be much more stable when these polarizations are parallel than when they are orthogonal. In the latter case the instability pump threshold can be as low as four times the first laser threshold, and the laser dynamics shows Lorenz-type features.

Ultracompact and Low-Power Plasmonic MZI Switch Using Cyclomer Loading

2015

We present a $2\times 2$ hybrid silicon-plasmonic thermooptic (TO) asymmetric Mach–Zehnder interferometric (MZI) switch having only 40- $\mu \text{m}$ long active cyclomer-loaded plasmonic phase arms. It requires less than 12 mW of power and has 2/5- $\mu \text{s}$ ON/OFF-times, respectively, a modulation depth higher than 90% and a 13.2-dB extinction ratio. Data traffic evaluation has been carried out using 10-Gb/s nonreturn-to-zero streams, yielding error-free operation at both switching states with power penalties ranging between 1 to 4.8 dB. The use of the cyclomer loading having a higher TO coefficient than polymethyl methacrylate has resulted to the smallest footprint among plasmonic …