Search results for "switching."
showing 10 items of 276 documents
Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle
2012
Abstract Background The expression of PDK4 is elevated by diabetes, fasting and other conditions associated with the switch from the utilization of glucose to fatty acids as an energy source. It is previously shown that peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a master regulator of energy metabolism, coactivates in cell lines pyruvate dehydrogenase kinase-4 (PDK4) gene expression via the estrogen-related receptor α (ERRα). We investigated the effects of long-term high-fat diet and physical activity on the expression of PDK4, PGC-1α and ERRα and the amount and function of mitochondria in skeletal muscle. Methods Insulin resistance was induced by a high-fat (HF) d…
A Multiple Surrogate Assisted Decomposition Based Evolutionary Algorithm for Expensive Multi/Many-Objective Optimization
2019
Many-objective optimization problems (MaOPs) contain four or more conflicting objectives to be optimized. A number of efficient decomposition-based evolutionary algorithms have been developed in the recent years to solve them. However, computationally expensive MaOPs have been scarcely investigated. Typically, surrogate-assisted methods have been used in the literature to tackle computationally expensive problems, but such studies have largely focused on problems with 1–3 objectives. In this paper, we present an approach called hybrid surrogate-assisted many-objective evolutionary algorithm to solve computationally expensive MaOPs. The key features of the approach include: 1) the use of mul…
Design and realization of a DC/DC converter with a partially saturated inductor
2017
DC/DC converters, in some types of applications such as portable equipments, can require more space than it is actually available. The inductor is typically the most bulky element and the possibility to reduce its size can save up to 50% of the converter volume and area [1][2], thus increasing the power density. This reduction, however, comes with nonlinear effects caused by the saturation of the ferromagnetic core. An appropriate modelling of the inductor and of the converter circuit is needed for guaranteeing a good output power quality (Fig. 1). A Boost converter with an inductor in the partially saturated roll-off operating zone was designed and realized to study the behaviour of DC/DC …
Review: Electrostatically actuated nanobeam-based nanoelectromechanical switches – materials solutions and operational conditions
2018
This review summarizes relevant research in the field of electrostatically actuated nanobeam-based nanoelectromechanical (NEM) switches. The main switch architectures and structural elements are briefly described and compared. Investigation methods that allow for exploring coupled electromechanical interactions as well as studies of mechanically or electrically induced effects are covered. An examination of the complex nanocontact behaviour during various stages of the switching cycle is provided. The choice of the switching element and the electrode is addressed from the materials perspective, detailing the benefits and drawbacks for each. An overview of experimentally demonstrated NEM swi…
Opioid-induced hyperalgesia after rapid titration with intravenous morphine: Switching and re-titration to intravenous methadone.
2012
Rapid titration with intravenous morphine (IV-MO) provides fast and efficient pain relief in cancer patients with severe-excruciating pain. However, some patients, after an initially favourable response, can develop an hyperexcitated state unrelieved or worsened by further dose increments.Eighty-one patients admitted on emergency basis titrated with IV-MO were assessed.12 patients were unsuccessfully titrated with IV-MO. Switching to intravenous methadone (IV-ME) and titrating the doses proved to be successfully.In escalating opioid doses rapidly a recognition of the development of hyperalgesia should be suspected. Increasing doses of opioids may stimulate rather than inhibiting the central…
Transfery poselskie w Sejmie III RP jako element strategii politycznej
2019
The article aims to explain the phenomenon of parliamentary party switching in the context of political strategy Switching parties by legislators during the term is often seen as an opportunistic behavior, focused on obtaining attractive places on electoral party lists The paper’s goals are to determine if the legislators’ will to switch parties is correlated with the party public support and, finally, if the deputies truly have better chances of winning reelection if they switch parties
Micro-interactional insights from the English as a foreign language classroom
2014
In this paper, we examine instances of the methods pupils deploy to do language policy in an English as a foreign language classroom in Sweden, where there is a locally practised English-only rule. Although we exemplify some more tacit methods of constructing a monolingual classroom (Slotte-Lüttge 2007), we focus primarily on instances where pupils police other pupils and on occasion even the teacher, when they are perceived not to be upholding the rule. This blatantly explicit method of pupils doing language policy, which we term language policing, generally serves to (re-) establish and maintain English as the medium of interaction and instruction. The data for this study consists of vide…
Bayesian temporal and spatio-temporal Markov switching models for the detection of influenza outbreaks
2017
Influenza is a disease which affects millions of people every year and causes hundreds of thousends of deads every year. This disease causes substantial direct and indirect costs every year. The influenza epidemic have a particular behavior which shapes the statistical methods for their detection. Seasonal epidemics happen virtually every year in the temperate parts of the globe during the cold months and extend throughout whole regions, countries and even continents. Besides the seasonal epidemics, some nonseasonal epidemics can be observed at unexpected times, usually caused by strains which jump the barrier between animals and humans, as happened with the well known Swine Flu epidemic, w…
Stability of stochastic nonlinear systems with state-dependent switching
2013
In this paper, the problem of stability on stochastic systems with state-dependent switching is investigated. To analyze properties of the switched system by means of Itô’s formula and Dynkin’s formula, it is critical to show switching instants being stopping times. When the given active-region set can be replaced by its interior, the local solution of the switched system is constructed by defining a series of stopping times as switching instants, and the criteria on global existence and stability of solution are presented by Lyapunov approach. For the case where the active-region set can not be replaced by its interior, the switched systems do not necessarily have solutions, thereby quasi-…
A Research Agenda for Evaluating Strength of Internal Preferences and External Influences in Consumer Smartphone Switching
2015
This article proposes a research agenda to study what causes consumers to switch smartphone manufacturer and operating system brands. International consumer survey is planned for data collection and structural equation modeling method will be used to extrapolate whether internal preferences play a larger role than external influences in consumers’ switching behavior. The effects are expected to be moderated by behavioral control, subjective uncertainty and prior switching experience and controlled with a set of constraint variables. As a theoretical contribution, we propose a new theory to evaluate switching primarily through the latent construct of magnitude of switch. Potential practical …