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showing 10 items of 2807 documents

Advantages of immediate two-dimensional echocardiography in patients with acute cardiac ischemic events

1995

Abstract We hypothesized that the assessment of kinetic alterations on two dimensional echocardiogram (2DE) would provide greater diagnostic information than clinical symptoms and ECG changes only. The study was aimed to determine sensitivity of 2DE in patients with cardiac ischemic events and to improve the indications to thrombolysis. Three-hundred ninety-one patients (87 F; 304 M) hospitalized for suspected acute myocardial infarction (AMI), first episode, within 4 h from the onset of symptoms, suitable for thrombolysis Killip class I–II and with unstable angina (UA), were admitted in the study. Patients had to show ECG changes and alterations of segmentary motion on 2DE performed at ent…

AdultMalemedicine.medical_specialtySystolemedicine.medical_treatmentMyocardial InfarctionMyocardial IschemiaIschemiaInfarctionSensitivity and SpecificityVentricular Function LeftElectrocardiographyFibrinolytic AgentsInternal medicinemedicineHumansThrombolytic TherapyAngina Unstablecardiovascular diseasesMyocardial infarctionAngioplasty Balloon CoronaryCoronary Artery BypassCreatine KinaseAgedKillip classAged 80 and overFirst episodeHeparinVascular diseaseUnstable anginabusiness.industryThrombolysisMiddle Agedmedicine.diseaseIsoenzymesSurvival RateEchocardiographyVentricular Function RightCardiologyFemaleCardiology and Cardiovascular MedicinebusinessInternational Journal of Cardiology
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Therapeutic management in Sicilian patients with definite arrhythmogenic right ventricular dysplasia/cardiomyopathy and focus on the role of implanta…

2014

Arrhythmogenic Right Ventrticular Dysplasia/Cardiomyopathy(ARVD/C) is an inherited cardiomyopathy characterized by right ven-tricularmyocytelosswithfibrofattyreplacement,ahighriskofventric-ular arrhythmias (VA) and sudden cardiac death (SCD) [1]. Preventionof SCD represents the most important management strategy and theachievement of this target can be reached by different therapeuticstrategies including implantable cardioverter-defibrillator (ICD)implantation, pharmacologic therapy, catheter ablation of ventriculartachycardia (VT) and cardiac transplantation [2,3]. The aim of thisstudy is to examine the outcome of the different therapies adopted ina group of affected patients, focusing on th…

AdultMalemedicine.medical_specialtyTime FactorsCardiomyopathymedicine.medical_treatmentCardiomyopathyCatheter ablationImplantable cardioverterdefibrillatorSudden deathInternal medicinemedicineHumansMedical managementSicilySurvival rateArrhythmogenic Right Ventricular DysplasiaCardiomyopathy; Implantable cardioverterdefibrillator; Medical management; Predictors; Sudden deathSudden deathbusiness.industryPrognosisImplantable cardioverter-defibrillatormedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareDefibrillators ImplantableArrhythmogenic right ventricular dysplasiaSurvival RateTransplantationDeath Sudden CardiacTreatment OutcomeHeart failureCardiologyFemaleMorbidityCardiology and Cardiovascular MedicinebusinessFollow-Up StudiesPredictorInternational Journal of Cardiology
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Optimal Response to Cardiac Arrest study: Defibrillation waveform effects

2001

Abstract Introduction: Advances in early defibrillation access, key to the “Chain of Survival”, will depend on innovations in defibrillation waveforms, because of their impact on device size and weight. This study compared standard monophasic waveform automatic external defibrillators (AEDs) to an innovative biphasic waveform AED. Material and methods: Impedance-compensated biphasic truncated exponential (ICBTE) and either monophasic truncated exponential (MTE) or monophasic damped sine (MDS) AEDs were prospectively, randomly assigned by date in four emergency medical services. The study design compared ICBTE with MTE and MDS combined. This subset analysis distinguishes between the two clas…

AdultMalemedicine.medical_specialtyTime FactorsEndpoint DeterminationDefibrillationmedicine.medical_treatmentElectric CountershockEmergency NursingReturn of spontaneous circulationhemic and lymphatic diseasesInternal medicineIntensive careHumansMedicineChain of survivalCardiopulmonary resuscitationAutomated external defibrillatorAgedAged 80 and overbusiness.industryEquipment DesignMiddle Agedmedicine.diseaseSurvival AnalysisCardiopulmonary ResuscitationDefibrillators ImplantableHeart ArrestSurgeryEuropeTreatment OutcomeShock (circulatory)Ventricular fibrillationEmergency MedicineCardiologyFemalemedicine.symptomCardiology and Cardiovascular MedicinebusinessResuscitation
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Chronic sacral spinal nerve stimulation for fecal incontinence: long-term results with foramen and cuff electrodes.

2002

PURPOSE: Sacral spinal nerve stimulation is a new therapeutic approach for patients with severe fecal incontinence owing to functional deficits of the external anal sphincter. It aims to use the morphologically intact anatomy to recruit residual function. This study evaluates the long-term results of the first patients treated with this novel approach applying two techniques of sacral spinal nerve stimulator implantation. METHODS: Six patients underwent either of two techniques for electrode placement: one “closed” (electrodes placed through the sacral foramen) and one “open” (cuff electrodes placed after sacral laminectomy). Follow-up evaluation of their continence status ranged from 5 to …

AdultMalemedicine.medical_specialtyTime FactorsExternal anal sphincterManometrymedicine.medical_treatmentLumbosacral PlexusAnal CanalElectric Stimulation TherapyForamenMedicineFecal incontinenceHumansbusiness.industryGastroenterologyLaminectomyLaminectomyGeneral MedicineMiddle AgedColorectal surgerySurgeryElectrodes ImplantedTreatment OutcomeSpinal nerveCuffChronic DiseaseFeasibility StudiesIntractable painFemalemedicine.symptombusinessFecal IncontinenceFollow-Up StudiesDiseases of the colon and rectum
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Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial: results up to 4 years from a randomised, multi…

2008

Summary Background Carotid stenting is a potential alternative to carotid endarterectomy but whether this technique is as safe as surgery and whether the long-term protection against stroke is similar to that of surgery are unclear. We previously reported that in patients in the Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial, the rate of any stroke or death within 30 days after the procedure was higher with stenting than with endarterectomy. We now report the results up to 4 years. Methods In this follow-up study of a multicentre, randomised, open, assessor-blinded, non-inferiority trial, we compared outcome after stenting with outcome …

AdultMalemedicine.medical_specialtyTime Factorsmedicine.medical_treatmentCarotid endarterectomyRisk AssessmentSeverity of Illness IndexFunctional LateralityDouble-Blind MethodRisk FactorsInternal medicineAngioplastyClinical endpointConfidence IntervalsMedicineHumansCarotid StenosisLife Tablescardiovascular diseasesLongitudinal StudiesStrokeEndarterectomyAgedProportional Hazards ModelsRetrospective StudiesEndarterectomy Carotidbusiness.industryHazard ratioAngioplastyMiddle Agedmedicine.diseaseSurgeryStrokeStenosisTreatment OutcomeCardiologyFemaleNeurology (clinical)Carotid stentingbusinessThe Lancet. Neurology
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Cardiac arrhythmias in patients with Danon disease.

2016

Aims Different cardiac arrhythmias have been suggested to be associated with Danon disease, e.g. Wolff–Parkinson–White syndrome. However, a systematic electrophysiological investigation of patients with Danon disease is lacking thus far. Methods and results Seven patients with Danon disease (4 males, 35.8 ± 10.8 years; 3 females, 51.3 ± 19.9 years) from 3 different families were studied. In all patients, the presence of Danon disease was confirmed by western blot of biopsy material or genetic testing. The patients were characterized by 12-lead electrocardiogram (ECG), Holter ECG, echocardiography, and serial implantable cardioverter defibrillator (ICD) interrogations (in ICD recipients). Al…

AdultMalemedicine.medical_specialtyTime Factorsmedicine.medical_treatmentElectric CountershockAction Potentials030204 cardiovascular system & hematologyAsymptomaticSudden cardiac death03 medical and health sciencesQRS complex0302 clinical medicineHeart RateRisk FactorsPhysiology (medical)Internal medicineMedicineHumansDanon diseasecardiovascular diseasesPR intervalAgedbusiness.industryCardiac arrhythmiaAtrial fibrillationArrhythmias CardiacMiddle AgedImplantable cardioverter-defibrillatormedicine.diseaseGlycogen Storage Disease Type IIbDefibrillators ImplantablePrimary PreventionDeath Sudden CardiacEchocardiographycardiovascular systemCardiologyAtrioventricular NodeElectrocardiography AmbulatoryFemalemedicine.symptomCardiology and Cardiovascular MedicinebusinessElectrophysiologic Techniques Cardiac030217 neurology & neurosurgeryEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
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Predictive factors of overall functioning improvement in patients with chronic schizophrenia and schizoaffective disorder treated with paliperidone p…

2018

BACKGROUND Long-acting injectable (LAI) antipsychotics can improve medication adherence and reduce hospitalisation rates compared with oral treatments. Paliperidone palmitate (PAL) and aripiprazole monohydrate (ARI) LAI treatments were associated with improvements in global functioning in patients with schizophrenia. OBJECTIVE The objective of this study was to assess the predictive factors of better overall functioning in patients with chronic schizophrenia and schizoaffective disorder treated with PAL and ARI. METHOD Enrolled were 143 (97 males, 46 females, mean age 38.24 years, SD = 12.65) patients with a diagnosis of schizophrenia or schizoaffective disorder, whom we allocated in two gr…

AdultMalemedicine.medical_specialtyaripiprazole monohydrate; global assessment of functioning; long-acting injectable antipsychotics; paliperidone palmitate; schizoaffective disorder; schizophrenia; neurology; neurology (clinical); psychiatry and mental health; pharmacology (medical)Global Assessment of FunctioningAripiprazoleSchizoaffective disorderPharmacyOutcome Assessment (Health Care)03 medical and health sciencesYoung Adult0302 clinical medicineglobal assessment of functioningInternal medicineOutcome Assessment Health CarePaliperidone PalmitatemedicineHumansPharmacology (medical)aripiprazole monohydratearipiprazole monohydrate; global assessment of functioning; long-acting injectable antipsychotics; paliperidone palmitate; schizoaffective disorder; schizophrenia; Adult; Antipsychotic Agents; Aripiprazole; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Paliperidone Palmitate; Psychotic Disorders; Schizophrenia; Young Adult; Outcome Assessment (Health Care)Paliperidone Palmitatebusiness.industrylong-acting injectable antipsychoticsMiddle Agedschizoaffective disordermedicine.disease030227 psychiatryPsychiatry and Mental healthNeurologyPsychotic DisordersSchizophreniaDelayed-Action PreparationsSettore SECS-P/03 - Scienza delle FinanzeSchizophreniaChronic schizophreniaAripiprazoleFemaleNeurology (clinical)business030217 neurology & neurosurgeryDiagnosis of schizophreniamedicine.drugAntipsychotic AgentsHuman psychopharmacology
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Lead-Related Infective Endocarditis in Latvia: A Single Centre Experience

2019

Background and Objectives: Over the last five decades cardiac implantable electronic devices (CIED) have become established as the mainstay for the treatment of permanent bradycardias, chronic heart failure and dangerous heart rhythm disturbances. These devices improve survival and quality of life in many patients. However, infections associated with CIED implantation, particularly lead-related infective endocarditis (LRIE), can offset all benefits and make more harm than good for the patient. To date, there are no other studies in Latvia, addressing patients with lead-related infective endocarditis. The objective of this study was to identify the most common pathogens associated with LRIE …

AdultMalemedicine.medical_specialtymedicine.drug_classAntibioticsDiseasemedicine.disease_causeArticleAntibiotic resistanceQuality of lifelead-related infective endocarditisRisk FactorsInternal medicinemedicineHumansAgedRetrospective StudiesAged 80 and overHeart Failurelcsh:R5-920cardiac implantable electronic devicesEndocarditisbusiness.industryArrhythmias CardiacGeneral Medicinecardiac device infectionProstheses and ImplantsMiddle Agedmedicine.diseaseLatviaLRIE mortalityLeadStaphylococcus aureusEchocardiographyInfective endocarditisHeart failureCIED complicationFemalelead-related infective endocarditis; cardiac implantable electronic devices; cardiac device infection; CIED complication; LRIE mortalityCoagulasebusinesslcsh:Medicine (General)Medicina
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The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outc…

2008

Aims We sought to determine the association between two major biomarkers, the inactive N-terminal fragment of brain natriuretic peptide (NT-proBNP) and tissue inhibitor of metalloproteinase-1 (TIMP-1) and long-term cardiovascular outcomes in a cohort of subjects who had a myocardial infarction or unstable angina 3–36 months previously. Methods and results Plasma NT-proBNP and TIMP-1 were measured in a nested case control study of 250 randomly matched subject pairs enrolled in the long-term intervention with pravastatin in ischaemic disease (LIPID) and LIPID extended follow-up studies. Cases ( n = 250) were defined as those who had a cardiovascular death, non-fatal myocardial infarction or s…

AdultMalemedicine.medical_specialtymedicine.drug_classMyocardial InfarctionCoronary AngiographyGastroenterologyLeukocyte CountRisk FactorsInternal medicineNatriuretic Peptide BrainmedicineNatriuretic peptideHumansAngina UnstableAgedPravastatinTissue Inhibitor of Metalloproteinase-1Framingham Risk Scorebusiness.industryAnticholesteremic AgentsCase-control studyOdds ratioMiddle AgedPrognosisBrain natriuretic peptidePeptide FragmentsC-Reactive ProteinEndocrinologyQuartileCase-Control StudiesNested case-control studyFemaleCardiology and Cardiovascular MedicinebusinessBiomarkersPravastatinmedicine.drugEuropean Heart Journal
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Nemaline myopathy and heart failure: role of ivabradine; a case report

2015

Background Nemaline myopathy (NM) is a rare congenital myopathy characterized by muscle weakness, hypotonia and the presence in muscle fibers of inclusions known as nemaline bodies and a wide spectrum of clinical phenotypes, ranging from severe forms with neonatal onset to asymptomatic forms. The adult-onset form is heterogeneous in terms of clinical presentation and disease progression. Cardiac involvement occurs in the minority of cases and little is known about medical management in this subgroup of NM patients. We report a rare case of heart failure (HF) in a patient with adult-onset NM in whom ivabradine proved to be able to dramatically improve the clinical picture. Case presentation …

AdultMalemedicine.medical_specialtymedicine.medical_treatmentDilated cardiomyopathyCase ReportMyopathies NemalineElectrocardiographyNemaline myopathyInternal medicinemedicineHumansIvabradineCarvedilolNemaline myopathyHeart FailureEjection fractionbusiness.industryDilated cardiomyopathyCardiovascular AgentsBenzazepinesmedicine.diseaseImplantable cardioverter-defibrillatorCongenital myopathyTreatment OutcomeEchocardiographyHeart failureCardiologybusinessCardiology and Cardiovascular MedicineIvabradinemedicine.drugBMC Cardiovascular Disorders
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