Search results for "talin"
showing 10 items of 126 documents
The influence of storage method on the transparency of pig crystalline lens
2019
Este artículo se ha publicado de forma definitiva en: http://www.scielo.br/pdf/abo/v82n1/0004-2749-abo-82-01-0056.pdf Purpose: The porcine eye is frequently used as a research model. This paper analyzes the effect of different storage methods on the transparency of pig crystalline lens. Methods: A spectral transmission curve (from 220 to 780 nm) for the crystalline lens was determined experimentally after storage in different conditions: saline solution, formalin, castor oil, and freezing at -80°C. The total transmission in the visible spectrum, which was used as an index of transparency, was calculated from these curves. For comparative purposes, fresh lenses were evaluated and used as con…
International Scientific Conference "Socio-Political and Religious Ideas and Movements in the 20th-21st Centuries", Latvia, Riga, 4-5 October 2018 : …
2018
The conference facilitated the exchange of ideas and the results of the latest studies on the reciprocity and significance of religious and socially political ideas (ideologies) in contemporary society. In the modern-day ever-changing political situation, an increasing danger to the safety and stability of society is caused by the manipulations of the seemingly traditional conceptions of ethical, religious and cultural values evident in the public discourse and media space. Under the impact of global processes, social anxiety and ethical disorientation facilitate a dangerous trend to trust the populist ideologies and quasi-religious ideas, as well as increase the level of radicalisation of …
Contextualising Baxtin’s Linguistic Ideas
2012
Summary This article discusses the origins and formation of the notion of ‘metalinguistics’ in Mixail Mixajlovič Baxtin’s (1895–1975) writings. It is argued that the discussion of metalinguistics and the division of labour within the study of language in the United States in the 1940s and 1950s may have exerted a more profound influence on the formation of Baxtin’s linguistic views than was previously thought. The article investigates the nature and extent of this interaction and shows that there are interesting parallels between Baxtin’s conception of metalinguistics and the metalinguistics writings of George L. Trager (1906–1992). This suggests that, apart from any purely terminological i…
On the reception of Wilhelm von Humboldt’s linguistic ideas in the Soviet Union from the late 1920s to the early 1950s
2015
The present article discusses the Soviet reception of Humboldt’s linguistic ideas, focusing on different interpretations of his ideas during the period between the latter half of the 1920s and the early 1950s. While Humboldt’s idea of the inner form of language was an important ingredient in Shpet’s phenomenology, the attitude towards Humboldt changed radically in the late 1920s and early 1930s when the ‘bolshevization’ of the sciences had reached linguistics. The idea that language, nation, and culture are closely interconnected was at odds with the ‘Marxist’ idea of class-language, according to which linguistic diversity derives from the socio-economic characteristics of societies. In the…
La relación entre conocimientos gramaticales y el aprendizaje de prácticas discursivas. El adjetivo como ejemplo
2017
Una gramática pedagógica ha de recoger los conocimientos gramaticales relevantes para la educación lingüística y ha de mostrar cómo estos conocimientos permiten reflexionar sobre la lengua y utilizarla de forma más consciente en sus distintos usos sociales. En parte, estos conocimientos hacen referencia a las nociones de la tradición gramatical, pero consideradas desde una perspectiva funcional, es decir, en relación con el papel que tienen en el discurso. Por ello, no se trata solo de saber cómo es una forma lingüística, sino también para qué sirve y cómo se utiliza adecuadamente en distintas actividades discursivas. Esta reflexión ha de vincularse, además, a actividades de aprendizaje que…
La divisa de las granadas del rey Enrique IV de Castilla y su estela posterior
2015
ABSTRACT: This study analyzes the meaning of the impresa or device of the pomegranates, with the motto « Agro dulce », utilized by Henry IV (1425-1474), of the House of Trastamara, King of Castile from 1454 until his death. By means of a review of vestiges that remain of the device, especially in architectonic elements, I postulate that the pomegranate may have been used as the family impresa of the House of Trastamara and their descendants. This, it seems, can be deduced from the pictura of the device in several personal imprese of relatives who lived in the sixteenth century. KEYWORDS: pomegranate, devices, royal clemency, Henry IV, Catholic Monarchs, Catherine of Aragon, Charles V, Phili…
Effect of some indole derivatives on xenobiotic metabolism and xenobiotic-induced toxicity in cultured rat liver slices.
1999
In this study the effect of some indole derivatives on xenobiotic metabolizing enzymes and xenobiotic-induced toxicity has been examined in cultured precision-cut liver slices from male Sprague-Dawley rats. While treatment of rat liver slices for 72 hours with 2-200 microM of either indole-3-carbinol (I3C) or indole-3-acetonitrile (3-ICN) had little effect on cytochrome P-450 (CYP)-dependent enzyme activities, enzyme induction was observed after in vivo administration of I3C. The treatment of rat liver slices with 50 microM 3,3'-diindolylmethane (DIM; a dimer derived from I3C under acidic conditions) for 72 hours resulted in a marked induction of CYP-dependent enzyme activities. DIM appears…
Pretreatment with potent P-glycoprotein ligands may increase intestinal secretion in rats.
2001
The expression of P-glycoprotein is induced in cell cultures upon exposure to various inducers. Therefore, the aim of the present study was to evaluate the in-vivo relevance of this observation, i.e. the influence of chronic pretreatments with selected drugs -- all of which are ligands to P-glycoprotein (P-gp) as demonstrated in radioligand binding studies and all of which have some or a considerable effect on P-gp expression in Caco-2 cells -- on the effective intestinal permeabilities of the model compound talinolol in rats employing in-situ single-pass intestinal perfusion of three different gut segments. Talinolol was selected, because it shows high selectivity for one of the exsorptive…
Predicting Delay in Reading Achievement in a Highly Transparent Language
2004
A random sample of 91 preschool children was assessed prior to receiving formal reading instruction. Verbal and nonverbal measures were used as predictors for the time of instruction required to accurately decode pseudowords in the highly orthographically regular Finnish language. After 2 years, participants were divided into four groups depending on the duration of instruction they had required to reach 90 % accuracy in their reading of pseudowords. Participants were classified as precocious decoders (PD), who could read at school entry; early decoders (ED), who learned to read within the first 4 months of Grade 1; ordinary decoders (OD), who learned to read within 9 months; and late deco…
Evidence for the mechanosensor function of filamin in tissue development
2016
AbstractCells integrate mechanical properties of their surroundings to form multicellular, three-dimensional tissues of appropriate size and spatial organisation. Actin cytoskeleton-linked proteins such as talin, vinculin and filamin function as mechanosensors in cells, but it has yet to be tested whether the mechanosensitivity is important for their function in intact tissues. Here we tested, how filamin mechanosensing contributes to oogenesis in Drosophila. Mutations that require more or less force to open the mechanosensor region demonstrate that filamin mechanosensitivity is important for the maturation of actin-rich ring canals that are essential for Drosophila egg development. The ope…