Search results for "talin"
showing 10 items of 126 documents
Refractive lens exchange with a multifocal diffractive aspheric intraocular lens
2012
PURPOSE: To evaluate the safety, efficacy and predictability after refractive lens exchange with multifocal diffractive aspheric intraocular lens implantation. METHODS: Sixty eyes of 30 patients underwent bilateral implantation with AcrySof® ReSTOR® SN6AD3 intraocular lens with +4.00 D near addition. Patients were divided into myopic and hyperopic groups. Monocular best corrected visual acuity at distance and near and monocular uncorrected visual acuity at distance and near were measured before and 6 months postoperatively. RESULTS: After surgery, uncorrected visual acuity was 0.08 ± 0.15 and 0.11 ± 0.14 logMAR for the myopic and hyperopic groups, respectively (50% and 46.67% of patients ha…
Contrast sensitivity after refractive lens exchange with a multifocal diffractive aspheric intraocular lens
2013
Purpose: To evaluate distance and near contrast sensitivity (CS) under photopic and mesopic conditions before and after refractive lens exchange (RLE) and implantation of the aspheric AcrySof ReSTOR (SN6AD3 model) intraocular lens (IOL) Methods: Sixty eyes of 30 consecutive patients after RLE underwent bilateral implantation with the aspheric AcrySof ReSTOR IOL. The patients sample was divided into myopic [n=15, mean spherical equivalent (SE) -6.87± 2.03 diopters (D)] and hyperopic (n=15, mean SE +4.52±1.14 D) groups. Monocular uncorrected visual acuity at distance and near (UCVA and UCNVA, respectively) and monocular best corrected visual acuity at distance and near (BCVA and BCNVA, respec…
Dimensión metacognitiva de las construcciones sintácticas suspendidas: Estudio descriptivo con pacientes afásicos españoles
2016
By taking into consideration conversational outputs from aphasic Spanish speakers, a functional characterisation of suspended syntactic constructions will be provided here. Suspensions of syntactic constructions may be initially thought of as attributed to a language processing deficit in people with aphasia, which is, in fact, only partly the case. An examination of conversational data demonstrates, however, that a comprehensive explanation of syntactic suspensions requires a re-assessment of this phenomenon in the realm of meta-cognitive processes associated with language behaviour. Five general types of procedures and contexts for suspended syntactic constructions will be proposed and di…
Metalinguaggio nella Valutazione dell'Afasia
2019
Metalinguaggio nella Valutazione dell'Afasia (Rosell-Clari & Hernández-Sacristán, 2019) es una versión adaptada al italiano y abreviada de Rosell Clari & Hernández Sacristán, 2014). Esta prueba fue desarrollada inicialmente para evaluar las habilidades metalingüísticas naturales en personas con afasia (Hernández-Sacristán, Rosell-Clari, Serra-Alegre y Quiles-Climent, 2012). Las habilidades metalingüísticas naturales se refieren al uso del lenguaje que revela reflexividad (Hockett, 1960); es decir, la distancia perceptiva del hablante con respecto a su propio comportamiento verbal (Werner & Kaplan, 1978). Esta autoconciencia del lenguaje nos permite monitorear nuestros propios comportamiento…
La construcció del coneixement gramatical en aprenents d'educació primària i secundària: algunes aproximacions a l'aprenentatge del verb
2017
El verb és una de les categories que una gramàtica escolar ha d’abordar necessàriament, tant pel que fa al coneixement de la noció i de la seva relació amb altres categories, com per la funció fonamental que pren en l’escriptura. En aquest article presentem tres recerques que descriuen el procés d’aprenentatge que els alumnes de primària i de secundària segueixen a l’hora d’aprendre continguts vinculats amb el verb: el temps del present, el mode verbal i la complementació verbal. Aquests treballs mostren quines estratègies desenvolupen els aprenents i quins obstacles han d’afrontar per desenvolupar un raonament gramatical. Dels estudis es desprèn que determinades intervencions didàctiques (…
β2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding
2008
AbstractLeukocyte integrins of the β2 family are essential for immune cell-cell adhesion. In activated cells, β2 integrins are phosphorylated on the cytoplasmic Thr758, leading to 14-3-3 protein recruitment to the β2 integrin. The mutation of this phosphorylation site impairs cell adhesion, actin reorganization, and cell spreading. Thr758 is contained in a Thr triplet of β2 that also mediates binding to filamin. Here, we investigated the binding of filamin, talin, and 14-3-3 proteins to phosphorylated and unphosphorylated β2 integrins by biochemical methods and x-ray crystallography. 14-3-3 proteins bound only to the phosphorylated integrin cytoplasmic peptide, with a high affinity (Kd, 261…
The molecular basis of filamin binding to integrins and competition with talin.
2006
The ability of adhesion receptors to transmit biochemical signals and mechanical force across cell membranes depends on interactions with the actin cytoskeleton. Filamins are large, actin-crosslinking proteins that connect multiple transmembrane and signaling proteins to the cytoskeleton. Here, we describe the high-resolution structure of an interface between filamin A and an integrin adhesion receptor. When bound, the integrin beta cytoplasmic tail forms an extended beta strand that interacts with beta strands C and D of the filamin immunoglobulin-like domain (IgFLN) 21. This interface is common to many integrins, and we suggest it is a prototype for other IgFLN domain interactions. Notabl…
Potential of the EPA/DHA 6/1 formulation to prevent endothelial dysfunction and cardiopulmonary remodeling in pulmonary arterial hypertension in rats
2016
Pulmonary arterial hypertension (PAH) is characterized by remodeling of the small pulmonary arteries leading to a progressive increase in pulmonary vascular resistance and right ventricular failure. Pulmonary endothelial dysfunction, inflammation and oxidative stress promote the development of pulmonary hypertension. Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) have been shown to protect the cardiovascular system and reduce inflammation and oxidative stress. The present study evaluate the potential of EPA:DHA 6:1 to prevent monocrotaline-induced PAH in rats. EPA:DHA 6:1 treatment (500 mg/kg/d, p.o) prevented the MCT-induced mean pul…
La « Révolution Conservatrice » en linguistique : linguiste Staline entre « notions essentielles » et l’esprit de Weimar
2021
Fascicule en libre accès sur le site de l'éditeur - ISBN : 978-5-91674-626-6; International audience; Publié lors de la discussion linguistique de 1950, le texte de Staline laisse entendre une continuité avec la tradition, ce qui implique l’image d’une société soviétique qui a réussi à conserver son caractère «traditionnaliste» malgré des coupures historiques évidentes. Cette «continuité» serait en grande partie assurée par la langue dite nationale. Plusieurs éléments «révolutionnaires-conservateurs» du texte de Staline font penser à la métaphore de l’«Allemagne russe» comme à l’une de ses sources conceptuelles.
Modulation of drug transport by selected flavonoids: Involvement of P-gp and OCT?
2004
Flavonoids, as a common component of daily nutrition, are a possible source of interference with absorption processes, due to modulation of transporting proteins. In this study, the influence of selected flavonoids (quercetin, isoquercitrin, spiraeoside, rutin, kaempferol, naringenin, naringin, and kaempferol) on the transport of the P-gp substrate [3H]talinolol across Caco-2 cell monolayers was investigated. To elucidate the mechanism behind the interaction observed in this system the potency of the flavonoids to replace [3H]talinolol from its P-gp binding site as well as their activity to inhibit OCT2-mediated [14C]TEA uptake into LLC-PK(1) cells were measured, as P-gp and OCT have been s…