Search results for "talk"
showing 10 items of 241 documents
Common miRNA Patterns of Alzheimer's Disease and Parkinson's Disease and Their Putative Impact on Commensal Gut Microbiota.
2019
With the rise of Next-Generation-Sequencing (NGS) methods, Micro-RNAs (miRNAs) have achieved an important position in the research landscape and have been found to present valuable diagnostic tools in various diseases such as multiple sclerosis or lung cancer. There is also emerging evidence that miRNAs play an important role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD) or Parkinson’s disease (PD). Apparently, these diseases come along with changes in miRNA expression patterns which led to attempts from researchers to use these small RNA species from several body fluids for a better diagnosis and in order to observe disease progression. Additionally, it…
Exploring a regulatory role for mast cells: 'MCregs'?
2010
Regulatory cells can mould the fate of the immune response by direct suppression of specific subsets of effector cells, or by redirecting effectors against invading pathogens and infected or neoplastic cells. These functions have been classically, although not exclusively, ascribed to different subsets of T cells. Recently, mast cells have been shown to regulate physiological and pathological immune responses, and thus to act at the interface between innate and adaptive immunity assuming different functions and behaviors at discrete stages of the immune response. Here, we focus on these poorly defined, and sometimes apparently conflicting, functions of mast cells.
Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis.
2008
Abstract Background Obesity in postmenopausal women is associated with increased breast cancer risk, development of more aggressive tumors and resistance to certain anti-breast cancer treatments. Some of these effects might be mediated by obesity hormone leptin, acting independently or modulating other signaling pathways. Here we focused on the link between leptin and HER2. We tested if HER2 and the leptin receptor (ObR) can be coexpressed in breast cancer cell models, whether these two receptors can physically interact, and whether leptin can transactivate HER2. Next, we studied if leptin/ObR can coexist with HER2 in breast cancer tissues, and if presence of these two systems correlates wi…
“Congratulations, you’re on TV!”: Middle-space performances of live tweeters during the FIFA World Cup
2018
Social television has transformed the traditional role of the television viewers by providing ‘ordinary people’ access to the public stage. This article describes how public access to television affected the dialogues of Finnish tweeters on Twitter during the massive media event of the FIFA World Cup. Through the lens of digital conversation analysis, the study shows how the media publicity of tweets changed the direction of the interaction between tweeters and transformed their roles vis-à-vis the television show, making one of them into a ‘media flasher’ and the others viewers of his or her performance. The publicity was constructed as important through noticings, congratulations, and com…
Gripas vīrusa hemaglutinīna fragmenta strukturāla izpēte un eksponēšana uz vīrusiem līdzīgo daļiņu virsmas
2015
Iekļaujot vakcīnā konservatīvus vīrusa proteīnu domēnus, būtu iespējams nodrošināt plaša spektra aizsardzību pret dažādiem gripas vīrusu apakštipiem. Viens no šādiem konservatīviem rajoniem ir hemaglutinīna (HA) stalka peptīds HA2.3. Bakalaura darba mērķis bija noteikt HA2.3 struktūru, tā eksponēšanas iespējas uz dažādu vīrusiem līdzīgo daļiņu (VLP) virsmas, un pētīt šo daļiņu imunoloģiskās īpašības. Pētījumā tika veikta HA2.3 ekspresija, attīrīšana, kristalizācija. Izmantojot rentgenstaru difrakciju, tika noteikts, ka HA2.3 struktūra vides pH 5,5 atbilst natīvajai HA stalka trimēra post fusion konformācijai. HA2.3 tika ķīmiski konjugēts pie dažādu VLP virsmas, kuras pēc tam izmantoja peļu …
El stalking, un nuevo delito
2014
El último proyecto de reforma del Código Penal español en el año 2013 incorpora el llamado delito de stalking, o acoso insistente y reiterado a otra persona, con previsión de distintas conductas y pudiendo ser sujeto activo y pasivo tanto el hombre, la mujer o personas del mismo sexo.
Menti che si fondono. L'invischiamento relazionale tra stalker e vittima
2012
Why Am I the Only One You’re Talking to, Talk to Them, They Haven’t Said a Word? : Pitfalls and Challenges of Having the Child in the Focus of Family…
2021
Children with conduct disorders are at risk of being positioned in the family therapy as ‘the problem’. This study describes how the difficulties were talked about and how the child coped in this situation. The results showed: the parents produced symptom-oriented problem talk about the child’s behavior, rendering systemic reformulation of the problem challenging. The negative interaction made the climate unsafe and impaired consideration of the child’s behavior as a meaningful way for the child to become seen and heard. This study enriches understanding of the therapeutic challenge therapists face with high-risk families from the very beginning of the treatment. peerReviewed
TED TALKS izmantošana skolēnu runāšanas prasmju attīstīšanai angļu valodas stundās 11. klasē
2019
Diplomdarba mērķis ir noskaidrot kā TED Talks video ietekmē skolēnu runātprasmi angļu valodas stundās 11. klasē. Šāda diplomdarba tēma tika izvēlēta , jo autore uzskata, ka runātprasmju veicināšana ir vitāli svarīga angļu valodas stundu sastāvdaļa. Izvēlētā pētījuma metode bija gadījuma analīze Valmieras Viestura vidusskolas 11. klasē. Datu vākšanas metodes bija skolēnu aptaujas un runāšanas prasmju novērtēšana. Tika novadītas astoņas stundas, lai noskaidrotu TED Talks ietekmi uz skolēnu sniegumu. Pētījums atklāja skolēnu pozitīvo attieksmi pret TED Talks video lietošanu, kā arī varēja novērot skolēnu līdzdalības uzlabošanos. Autore secināja, ka TED Talks video var tikt izmantoti, lai veici…
Immediacy and distance in teacher talk—A comparative case study in German elementary- and outdoor school-teaching
2017
This case study examines authentic speech acts by a German primary school teacher in the classroom context and the outdoor learning location of a forest. The study will compare the degree of linguistic immediacy or distance in these two contexts, respectively. Once a week, the class is doing “outdoor school” [Draußenschule] in places of natural or cultural interest near to their school. The structural change in the teaching environment means a change in the communication setting. The question arises if the teacher speaks to the students differently indoors than outdoors. The theoretical reference framework for the study is provided by the linguistic model “language of immediacy and language…