Search results for "target"

Real-Life Outcomes of Coronary Bifurcation Stenting in Acute Myocardial Infarction (Zabrze–Opole Registry)

2021

Percutaneous coronary intervention (PCI) of bifurcation lesions is a technical challenge associated with high risk of adverse events, especially in primary PCI. The aim of the study is to analyze long-term outcomes after PCI for coronary bifurcation in acute myocardial infarction (AMI). The outcome was defined as the rate of major adverse cardiac event related to target lesion failure (MACE-TLF) (death-TLF, nonfatal myocardial infarction-TLF and target lesion revascularization (TLR)) and the rate of stent thrombosis (ST). From 306 patients enrolled to the registry, 113 were diagnosed with AMI. In the long term, AMI was not a risk factor for MACE-TLF. The risk of MACE-TLF was dependent on th…

Sampling Design in SHARE Wave 8 and Recruitment of Refreshment Samples until the Suspension of Fieldwork

2022

The aim of the SHARE survey design is to be able to draw inferences about the population of people aged 50 years or older across countries by using probability-based sampling. This chapter documents the sampling design adopted in the eighth wave of SHARE that had to be suspended due to COVID-19 in March 2020. Starting with a definition of the SHARE target population, we describe the protocol for harmonizing and documenting the sampling procedure and present the sampling frames used by the countries that recruited a baseline or refreshment sample in Wave 8. We then discuss some important aspects of the SHARE sampling designs, such as stratification, clustering, variation in selection probabi…

Identificazione di nuovi bersagli terapeutici nel microambiente nei Linfomi T Epatosplenici

THERAPEUTIC-LOADED LIPID NANOSTRUCTURES AND BRAIN DISEASES.

2012

Central Nervous System (CNS) diseases represent the largest and fastest growing area of unmet medical need since an alarming increase in brain disease incidence is going on. Despite major advances in neuroscience, many potential therapeutic agents are denied access to the CNS because of the existence of a physiological low permeable barrier, the Blood-Brain Barrier (BBB). To obtain an improvement of drug CNS performance, sophisticated approaches such as nanoparticulate systems are rapidly developing. In particular, in this chapter, the most recent data demonstrating the potential of lipid nanostructures, such as Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC), to tra…

Targeted NGS for species level phylogenomics: “made to measure” or “one size fits all”?

2017

Targeted high-throughput sequencing using hybrid-enrichment offers a promising source of data for inferring multiple, meaningfully resolved, independent gene trees suitable to address challenging phylogenetic problems in species complexes and rapid radiations. The targets in question can either be adopted directly from more or less universal tools, or custom made for particular clades at considerably greater effort. We applied custom made scripts to select sets of homologous sequence markers from transcriptome and WGS data for use in the flowering plant genus Erica (Ericaceae). We compared the resulting targets to those that would be selected both using different available tools (Hyb-Seq; M…

COSMIC project: consensus on the objectives of the metabolic syndrome in clinic

2018

Juan Pedro-Botet,1 Juan F Ascaso,2,3 Vivencio Barrios,4,5 Alejandro De la Sierra,6 Javier Escalada,7,8 Jesús Millán,9 Jose M Mostaza,10 Pablo Pérez-Martínez,8,11 Xavier Pintó,8,12 Jordi Salas-Salvadó,8,13 Pedro Valdivielso14 1Lipids and Vascular Risk Unit, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain; 2Endocrinology and Nutrition Service, Hospital Clínico, Universitat de Valencia, Valencia, Spain; 3INCLIVA Research Institute, Diabetes and Metabolic Diseases Ciber (Networked Biomedical Research Centres – CIBERDEM), Carlos III, Valencia, Spain; 4Cardiology Service, Hospit…

When a new technological product launching fails: A multi-method approach of facial recognition and E-WOM sentiment analysis

2018

Abstract The dual aim of this research is, firstly, to analyze the physiological and unconscious emotional response of consumers to a new technological product and, secondly, link this emotional response to consumer conscious verbal reports of positive and negative product perceptions. In order to do this, biometrics and self-reported measures of emotional response are combined. On the one hand, a neuromarketing experiment based on the facial recognition of emotions of 10 subjects, when physical attributes and economic information of a technological product are exposed, shows the prevalence of the ambivalent emotion of surprise. On the other hand, a nethnographic qualitative approach of sen…

The experimental facility for the Search for Hidden Particles at the CERN SPS

2019

The Search for Hidden Particles (SHiP) Collaboration has shown that the CERN SPS accelerator with its 400 $\mathrm{\small GeV/c}$ proton beam offers a unique opportunity to explore the Hidden Sector. The proposed experiment is an intensity frontier experiment which is capable of searching for hidden particles through both visible decays and through scattering signatures from recoil of electrons or nuclei. The high-intensity experimental facility developed by the SHiP collaboration is based on a number of key features and developments which provide the possibility of probing a large part of the parameter space for a wide range of models with light long-lived superweakly interacting particles…

Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions

2011

SummaryTuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by hamartomatous neurological lesions that exhibit abnormal cell proliferation and differentiation. Hyperactivation of mTOR pathway by mutations in either the Tsc1 or Tsc2 gene underlies TSC pathogenesis, but involvement of specific neural cell populations in the formation of TSC-associated neurological lesions remains unclear. We deleted Tsc1 in Emx1-expressing embryonic telencephalic neural stem cells (NSCs) and found that mutant mice faithfully recapitulated TSC neuropathological lesions, such as cortical lamination defects and subependymal nodules (SENs). These alterations were caused by enhanced gen…

A review of studies using the Körperkoordinationstest für Kinder (KTK)

2015

The Körperkoordinationstest für Kinder (KTK) (Kiphard & Schilling, 1974, 2007) is a standardized, norm-referenced measure used by physical therapists and occupational therapists in clinic and school practice settings to evaluate the motor coordination (MC) of 5- to 14-year-old children. To find out for which research purposes the KTK has been used and its reliability and validity, we conducted a systematic review. Searching five databases, we found 46 studies used the KTK over four decades. The KTK was widely used in Europe in children with typical and atypical development. The KTK was used to investigate associations, to test the effects of interventions and treatments, to identify or diag…