Search results for "taudit"

Immunoscore in Mismatch Repair-Proficient and -Deficient Colon Cancer

2017

Abstract The aim of this study was to investigate immune response and its prognostic significance in colon carcinomas using the previously described Immunoscore (IS). A population-based series of 779 colorectal cancers, operated on between 2000 and 2010, were classified according to tumour, node, metastasis (TNM) status, mismatch repair (MMR), and BRAF mutation status. Rectal cancer cases (n = 203) were excluded as a high proportion of these patients received preoperative neoadjuvant chemoradiotherapy. Tissue microarray (TMA) samples collected from the tumour centre and invasive front were immunostained for CD3 and CD8. Lymphocytes were then digitally calculated to categorize IS from grade …

Fyysinen aktiivisuus ja ravitsemus lasten terveyden edistämisessä - tavoitteena lihavuuden, tyypin 2 diabeteksen ja valtimotautien ehkäisy.

2019

Diplostomiasis ( Diplostomum spathaceum and related species).

2020

This book chapter describes various aspects of diplostomiasis caused by Diplostomum spathaceum: diagnosis, epidemiology, life cycle, transmission, developmental stages, population dynamics, effects of climate change on parasite distribution, and disease control and prevention. peerReviewed

Opposing health effects of hybridization for conservation

2021

The continuing decline of many natural plant and animal populations emphasizes the importance of conservation strategies. Hybridization as a management tool has proven successful in introducing gene flow to small, inbred populations, but can be also associated with health risks. For example, hybridization can change susceptibility to infection in either direction due to heterosis (hybrid vigor) and outbreeding depression, but such health effects have rarely been considered in the genetic management of populations. Here, we investigated the effects of experimental outcrossing between the critically endangered Saimaa landlocked salmon (Salmo salar m. sebago) and the genetically more diverse A…

Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome

2021

Simple Summary Lifestyle modifies cancer risk in the general public. How lifestyle modifies cancer risk in individuals carrying the inherited pathogenic gene variants in DNA mismatch repair genes (Lynch syndrome) remains understudied. We conducted a retrospective study with cancer register data to investigate associations between body weight, physical activity, and cancer risk among Finnish Lynch syndrome carriers (n = 465, 54% women). The results of our study indicated that longitudinal weight gain increases cancer risk, whereas being highly physically active during adulthood could decrease cancer risk in men. Further, women were observed to be less prone to lifestyle-related risk factors …

Sydäntautien ehkäisyn aloittamisessa ei alaikärajaa

2021

Toward Comprehensive Plant Microbiome Research

2020

Microbes have driven eco-evolutionary adaptations organizing biodiversity from the origin of life. They are ubiquitous and abundant, facilitating the biochemical processes that make Earth habitable and shape ecosystem structures, functions, and services. Recent studies reveal that commensalistic and beneficial microbes associated with wild and domesticated plants may aid in establishing sustainable agriculture for a changing climate. However, developing microbe-based biotechnologies and ecosystem services requires a thorough understanding of the diversity and complexity of microbial interactions with each other and with higher organisms. We discuss the hot and blind spots in contemporary re…

Myopia - maailmanlaajuinen epidemia

2021

• Myopian eli likinäköisyyden esiintyvyys on viime vuosikymmeninä lisääntynyt voimakkaasti. • Tähän ovat ilmeisesti vaikuttaneet voimakkaimmin lähikatselun lisääntyminen ja ulkona vietetyn ajan väheneminen. Perintötekijät selittävät myopiasta vain pienen osan. • Ulkoilun lisäämisellä ja pitkäkestoisen lähikatselun välttämisellä on voitu vähentää lasten myopian ­ilmaantuvuutta. • Useiden silmäsairauksien ja näkövammaisuuden riski lisääntyy myopian voimistuessa. • Atropiinisilmätippojen käytöstä on raportoitu olevan hyötyä likinäköisyyden etenemisen hidastamisessa, mutta pidempiaikaisista hyödyistä ja mahdollisista haitoista tarvitaan seurantatietoa. The prevalence of myopia has increased sig…

Menopause modulates the circulating metabolome: evidence from a prospective cohort study

2022

Abstract Aims We studied the changes in the circulating metabolome and their relation to the menopausal hormonal shift in 17β-oestradiol and follicle-stimulating hormone levels among women transitioning from perimenopause to early postmenopause. Methods and results We analysed longitudinal data from 218 Finnish women, 35 of whom started menopausal hormone therapy during the study. The menopausal transition was monitored with menstrual diaries and serum hormone measurements. The median follow-up was 14 months (interquartile range: 8–20). Serum metabolites were quantified with targeted nuclear magnetic resonance metabolomics. The model results were adjusted for age, follow-up duration, educat…

Exercise cardiac power and the risk of heart failure in men : A population-based follow-up study

2022

Background Little is known about exercise cardiac power (ECP), defined as the ratio of directly measured maximal oxygen uptake with peak systolic blood pressure during exercise on heart failure (HF) risk. We examined the association of ECP and the risk of HF. Methods This was a population-based cohort study of 2351 men from eastern Finland. The average time to follow-up was 25 years. Participants participated at baseline in an exercise stress test. A total of 313 cases of HF occurred. Results Men with low ECP (13.92 mL/mmHg, highest quartile), after adjusting for age. Low ECP was associated with a 1.96-fold risk (95%CI: 1.38 − 2.78, p < 0.001) of HF after additional adjustment for conventio…