Search results for "taz"
showing 10 items of 2702 documents
Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX.
2015
Human carbonic anhydrase IX (CA IX) is overexpressed in a number of solid tumors and is considered to be a marker for cellular hypoxia that it is not produced in most normal tissues. CA IX contributes to the acidification of the extracellular matrix, which, in turn, favors tumor growth and metastasis. Therefore, CA IX is considered to be a promising anti-cancer drug target. However, the ability to specifically target CA IX is challenging due to the fact that the human genome encodes 15 different carbonic anhydrase isoforms that have a high degree of homology. Furthermore, structure-based drug design of CA IX inhibitors so far has been largely unsuccessful due to technical difficulties regar…
Chemometric Approaches to Analyse the Composition of a Ewe’s Colostrum
2023
Colostrum is a major source of immunity in lambs and, in general, in all newborn ruminants. It allows the transfer of antibodies from the ewe to the lamb, and it becomes the exclusive source of nutrients for a newborn. Among the most significant Pearson correlations, the positive correlation between the Brix refractive index (Brix) and protein (0.90) should be noted. Both parameters (protein percentage and Brix) were then positively correlated with the percentage of fat (0.38 and 0.41), urea (0.81 and 0.67), calcium (0.39 and 0.29), and magnesium (0.58 and 0.59), as well as the yellowness (0.78 and 0.75). Somatic cell count (SCC) and pH, parameters which are indicators of subclinical mastit…
Costruzioni identitarie e di genere. Il caso Caster Semenya
2019
Nel 2009 i media riportano di un caso sportivo che suscita scalpore a livello internazionale: Caster Mokgadi Semenya, atleta sudafricana, dopo aver vinto la medaglia d’oro negli 800 metri femminili ai Mondiali di atletica leggera di Berlino, viene accusata di essere un uomo. A partire da quell’anno, numerosi commenti, articoli e interviste si sono succeduti toccando una questione discussa nella letteratura sulle differenze di genere.
In silico identification and experimental validation of hits active against KPC-2 β-lactamase
2018
Bacterial resistance has become a worldwide concern, particularly after the emergence of resistant strains overproducing carbapenemases. Among these, the KPC-2 carbapenemase represents a significant clinical challenge, being characterized by a broad substrate spectrum that includes aminothiazoleoxime and cephalosporins such as cefotaxime. Moreover, strains harboring KPC-type β-lactamases are often reported as resistant to available β-lactamase inhibitors (clavulanic acid, tazobactam and sulbactam). Therefore, the identification of novel non β-lactam KPC-2 inhibitors is strongly necessary to maintain treatment options. This study explored novel, non-covalent inhibitors active against KPC-2, …
Injury Evaluation in Teenage Cyclist-Vehicle Crash by Multibody Simulation
2014
Information on impact locations, impact situations and cyclist and pedestrian dynamics in impacts with passenger cars is fundamental for the development of effective solutions to improve cyclist and pedestrian protection. Accidentology research shows that cyclists typically have a higher impact location than the pedestrian, with a larger share of injuries from the windscreen area. Majority of accidents in Palermo, in the last years, happens at urban street (84%) that involve teenager (6.4%). In this paper simulation study captures dynamics and injuries to head and chest for teenager between a generic bicycle and a car model that is suitable for pedestrian or cyclist safety. Multibody simula…
Identification of subdominant sourdough lactic acid bacteria and their evolution during laboratory-scale fermentations
2007
Abstract Presumptive lactic acid bacterial cocci were found in six sourdoughs (out of 20) from the Abruzzo region (central Italy) and subjected to phenotypic and genotypic characterization. A total of 21 isolates, recognized as seven strains by randomly amplified polymorphic DNA (RAPD)–polymerase chain reaction (PCR) typing, were identified by a polyphasic approach, consisting of 16S rRNA gene sequencing, multiplex PCR assays and physiological features, as Enterococcus faecium and Pediococcus pentosaceus. Four strains belonging to those species and previously isolated from wheat kernels were inoculated in sterile flour to verify their capacity to grow in sourdough environment. Doughs with s…
A radiometric and petrographic interpretation of discrepancies on uranium content in samples collected at Alte Madonie Mounts region (Sicily, Italy)
2013
Abstract The main goal of this work is to evaluate a correlation between anomalous Uranium (U) content and petrographic features of some soil and rock samples collected at Alte Madonie Mounts region (North-central Sicily, Italy). A total of 41 samples of selected soils and rocks were collected, powdered, dried and sealed in “Marinelli” beakers for 20 days before the measurement to ensure that radioactive equilibrium between 226 Ra and 214 Bi was reached. Gamma-ray spectrometric analysis was used to quantify radioactivity concentrations. Mineralogical and chemical features of the samples were determined by X-ray Fluorescence (XRF), X-ray Diffractometry (XRD), Attenuated Total Reflection-Four…
La riforma amministrativa dei governi locali: "grande trasformazione" o gattopardesco maquillage?
2009
L’infanzia in gioco.Video education, Neuroeducation e sviluppo cognitivo-relazionale nei primi anni di vita
2020
La prospettiva del sistema integrato 0-6 previsto dal D.L. 65/2017 e la crescente eterogeneità morfologica delle classi della scuola italiana inducono giocoforza al rinnovamento complessivo del panorama scolastico italiano chiamando in causa un ripensamento epistemologico e prassico-metodologico della Pedagogia dell’Infanzia. A partire da tali considerazioni, in linea con una pista di studio e di ricerca avviata già nel 2015 presso l’Università di Palermo, il presente lavoro indaga la dimensione educativa del gioco a partire da due distinte angolazioni: quella della Neuroeducation e quella della Video education rispetto a due distinti ambiti: il mondo dei giochi e quello dei videogame, con …
Pena "illegale", giudicato, Corte Europea: dall'affare "Scoppola c. Italia" alle Sezioni Unite "Ercolano"
2018
La crisi del principio di intangibilità del giudicato costituisce il punto di partenza di un'analisi che ha ad oggetto la nota pronuncia "Scoppola c. Italia", con la quale si è affermato a livello convenzionale il principio della retroattività della lex mitior. Molte le implicazioni sul piano della giurisprudenza, le cui sentenze vengono prese in rassegna onde restituire uno scenario che apre al controllo della legalità della pena in executivis, espressione delle nuove direttive votate alla necessaria flessibilizzazione del giudicato. The crisis of the principle of intangibility of the judged constitutes the starting point of an analysis that concerns the well-known dictum "Scoppola v. Ital…