Search results for "techniques"
showing 10 items of 4426 documents
The oral KIF11 inhibitor 4SC‐205 exhibits antitumor activity and potentiates standard and targeted therapies in primary and metastatic neuroblastoma …
2021
Inhibidor de KIF11; Terapias dirigidas; Metástasis Inhibidor de KIF11; Teràpies dirigides; Metàstasi KIF11 inhibitor; Targeted therapies; Metastasis In summary, our study provides a rationale for the future therapeutic integration in clinical trials of 4SC-205, an structurally distinct oral KIF11 inhibitor that shows potent antitumor activity in multiple preclinical neuroblastoma models and sensitizes neuroblastoma cells to standard chemotherapy and specific neuroblastoma-targeted therapies. The financial support for this research was provided by Instituto de Salud Calos III (PI20/00530 to Miguel F. Segura; PI20/01107 to Rosa Noguera; PI17/02248 and CPII18/00027 to Anna Santamaria; PI19/013…
Controlled Release of Metformin Hydrochloride from Core-Shell Nanofibers with Fish Sarcoplasmic Protein
2019
Ficai, Anton/0000-0002-1777-0525; Karademir, Betul/0000-0003-1762-0284 WOS:000503463400074 PubMed ID: 31658758 Background and Objectives: A coaxial electrospinning technique was used to produce core/shell nanofibers of a polylactic acid (PLA) as a shell and a polyvinyl alcohol (PVA) containing metformin hydrochloride (MH) as a core. Materials and Methods: Fish sarcoplasmic protein (FSP) was extracted from fresh bonito and incorporated into nanofiber at various concentrations to investigate the influence on properties of the coaxial nanofibers. The morphology, chemical structure and thermal properties of the nanofibers were studied. Results: The results show that uniform and bead-free struct…
Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and func…
2016
ABSTRACT Mutations in Drosophila Swiss cheese (SWS) or its vertebrate orthologue neuropathy target esterase (NTE), respectively, cause progressive neuronal degeneration in Drosophila and mice and a complex syndrome in humans that includes mental retardation, spastic paraplegia and blindness. SWS and NTE are widely expressed in neurons but can also be found in glia; however, their function in glia has, until now, remained unknown. We have used a knockdown approach to specifically address SWS function in glia and to probe for resulting neuronal dysfunctions. This revealed that loss of SWS in pseudocartridge glia causes the formation of multi-layered glial whorls in the lamina cortex, the firs…
THE "PALAZZETTI" OF PANTELLERIA - MATERIALS AND TECHNIQUES OF THE MEDITERRANEAN VERNACULAR ARCHITECTURE AND GENIUS LOCI INTERPRETATION
2006
Mediterranean architecture, through its millenary history, expresses itself even through particular handmade that deeply characterized the country. The building treasure inside the Islands surrounding Sicily presents particular techniques and building systems that exploiting natural resources gave life to the original handmade and building technologies which are extremely functional and valuable in terms of eco-sustainability. Talking about architecture in Pantelleria means discovering ancient links about materials, techniques and the landscape. The Island is famous for its "Dammusi" (and "Palazzetti"), interesting handmade both for their morphological characteristics and for their technolo…
Non-chemical weeds management in two Mediterranean culinary herbs
2009
Weeds management is one of the most relevant constraints to the cultivation of Medicinal and Aromatic Plants, especially when they’re cultivated with “organic” methods, that, according to EU regulations, do not allow the use of chemicals. A strong interest is therefore devoted to pointing out “alternative” (agronomical and physical) methods for weeds control. This work reports the results of a trial performed in 2003-04 and 2004-05 in order to evaluate the effects on Coriander (Coriandrum sativum L.) and Fennel (Foeniculum vulgare Mill.) of four non-chemical methods for weeds control: FS (False seeding), PD (Flaming), MZ (Mechanical weeding), SM (Hand weeding) compared with two untreated co…
The Dual/Global Value of SARS-CoV-2 Genome Surveillance on Migrants Arriving to Europe via the Mediterranean Routes.
2021
Despite the pandemic, 34,154 migrants, refugees or asylum-seekers landed in Sicily (Italy) in 2020, representing the main point of entry by sea into Europe. The SARS-CoV-2 surveillance program among migrants arriving to Sicily via the Mediterranean Sea, made by the combination of clinical examination and molecular testing, has been integrated by full-genome sequencing strains using the NGS technology from the last week of February. To date, more than one hundred full-genome strains have been sequenced and 8 different lineages have been identified mostly belonging to the lineages B.1.1.7 and B.1.525. As global access to COVID-19 vaccines should be ensured, the need to provide more detailed i…
MAPs in Sicily: cultivation, uses, and potentiality
2013
In Sicily, MAPs have been used and cultivated for centuries, with many uses ranging from the preparation of fresh or stored food items, flavoring of foods and beverages, home-made human or animal therapy or even aesthetical purposes. Many of them grow spontaneously into such areas, and are claimed to play a significant role inside land biodiversity. The widespread belief that only under “natural” conditions MAPs find their optimum quality features has driven in many cases to their uncontrolled collection from the wild, and as a result many of them are nowadays at a risk of extinction. The field cropping of such spontaneous species could play an important role in safeguarding biodiversity, a…
Bacterial Cytolysin Perturbs Round Window Membrane Permeability Barrier In Vivo: Possible Cause of Sensorineural Hearing Loss in Acute Otitis Media
1998
ABSTRACT The passage of radioiodinated streptolysin-O (SLO) and albumin through the round window membrane (RWM) was studied in vivo. When applied to the middle ear, SLO became quantitatively entrapped in this compartment and no passage to the cochlea occurred. However, flux of radioiodinated albumin through the toxin-damaged RWM was observed. We propose that the passage of noxious macromolecules, such as proteases, from a purulent middle-ear effusion may be facilitated by pore-forming toxins, resulting in cochlear damage and sensorineural hearing loss.
Specific suppression of pentylenetetrazol-induced epileptiform discharges in CA3 neurons (hippocampal slice, guinea pig) by the organic calcium antag…
1989
Antiepileptic actions of the organic calcium antagonists flunarizine (cinnarizine derivate) and verapamil (papaverin derivat) on pentylenetetrazol-induced epileptic bioelectric activity were tested in CA3 neurones of hippocampal slices. In all experiments both calcium antagonists reduced the amplitudes and/or durations of paroxysmal depolarizations as well as their rate of occurrence, when the bath concentrations of flunarizine or verapamil exceeded 20 mumol/l. When they were added to the bath solution before pentylenetetrazol application, recordings of the resting membrane potential, of the membrane resistance, of action potentials and of spontaneous as well as of evoked excitatory and inh…
The Health Challenges at Menopause and Midlife: Sustainability, ICT Technology and Patient Empowerment
2017
The implementation of lifestyle is a most cost-effective approach to the management of menopause. Physical activity, for example, may be an appropriate measure to reduce the risk of osteoporosis and other non-communicable diseases affected by menopause. The difficulty with physical activity and other lifestyle measures is often the poor long-term adherence. There are several studies addressing the issue and describing the main variables that impact adherence. Both changes in the strategy, activity program, or even behavioural changes supported by psychological techniques, have been demonstrated to have an impact, though still limited.