Search results for "techniques"
showing 10 items of 4426 documents
Traditional Architecture and seismic security. Earthquake in the Madonie inner mountain area of Sicily: damages and construction techniques
2017
Tra il 1818 e il 1819 una serie di centri siciliani concentrati nell'area montuosa delle Madonie, furono colpiti a più riprese da una sequenza di scosse sismiche che provocarono numerosi danni all’edificato storico, sia diffuso che di pregio. Il contributo intende indagare i danni e le conseguenti ricostruzioni, con particolare riferimento alle tipologie edilizie e alle tecniche costruttive adottate prima e dopo il sisma. L'azione di verifica e monitoraggio delle condizioni delle fabbriche e i conseguenti interventi di consolidamento e riparazione sono efficacemente documentati in testi a stampa e nei report coevi al sisma e –soprattutto- da una copiosa documentazione archivistica. Si ident…
Preparation of ferulic acid derivatives and evaluation of their xanthine oxidase inhibition activity.
2007
Several ferulic acid ethyl esters (3a-h) were synthesized under the Knoevengel reaction condition and they were further reduced to afford the respective allylic alcohol derivatives (4a-g). Some of them were evaluated for the xanthine oxidase (XO) inhibitory activity. Among them, 3h exhibited a significant inhibitory activity with an IC50 value of 1.35 x 10(-5) M, while the IC50 value of allopurinol used as the positive control was 1.49 x 10(-5) M. The study suggested that the higher acidity of the phenolic OH group in the ferulic acid derivatives might result in improved XO inhibitory activity.
Cytotoxicity and modes of action of four Cameroonian dietary spices ethno-medically used to treat cancers: Echinops giganteus, Xylopia aethiopica, Im…
2013
Abstract Ethnopharmacological relevance. Echinops giganteus , Imperata cylindrica , Piper capense and Xylopia aethiopica are four medicinal spices used in Cameroon to treat cancers. Aim of the study The above plants previously displayed cytotoxicty against leukemia CCRF-CEM and CEM/ADR5000 cell lines as well as human pancreatic MiaPaCa-2 cells. The present study aims at emphasizing the study of the cytotoxicity and the modes of action of the above plants on a panel of ten cancer cell lines including various sensitive and drug-resistant phenotypes. The study has been extended to the isolation of the bioactive constituents from Echinops giganteus . Materials and methods The cytotoxicity of th…
Electrophysiological and morphological properties of Cajal–Retzius cells with different ontogenetic origins
2010
International audience; The different origins of Cajal-Retzius cells (CRc) as well as their diverse molecular profile suggest that this cell type may represent different neuronal subpopulations. In order to investigate whether CRc from different origins show distinct functional or morphological characteristics we used transgenic Dbx1(cre);ROSA26(YFP) mice in which two subpopulations of CRc, originating from the septum and ventral pallium (VP) at the pallial-subpallial border (PSB), were permanently labeled by yellow fluorescent protein (YFP) expression. Electrophysiological properties of YFP(+) and YFP(-) CRc were investigated by whole-cell patch-clamp recordings, while a thorough somatoden…
Probing the Conformational States of a pH-Sensitive DNA Origami Zipper via Label-Free Electrochemical Methods
2021
Funding Information: Financial support from EPSRC DTP (grant EP/R513349/1), the Emil Aaltonen Foundation, the Sigrid Jusélius Foundation, the Jane and Aatos Erkko Foundation, and the Vilho, Yrjö and Kalle Väisälä Foundation of the Finnish Academy of Science and Letters is gratefully acknowledged. This work was carried out under the Academy of Finland Centers of Excellence Programme (2014–2019). We acknowledge the provision of facilities and technical support by Aalto University Bioeconomy Facilities and OtaNano—Nanomicroscopy Center (Aalto-NMC) and Micronova Nanofabrication Center. Publisher Copyright: © 2021 The Authors. Published by American Chemical Society DNA origami structures represe…
Charles Darwin and the Origin of Life
2009
When Charles Darwin published The Origin of Species 150 years ago he consciously avoided discussing the origin of life. However, analysis of some other texts written by Darwin, and of the correspondence he exchanged with friends and colleagues demonstrates that he took for granted the possibility of a natural emergence of the first life forms. As shown by notes from the pages he excised from his private notebooks, as early as 1837 Darwin was convinced that “the intimate relation of Life with laws of chemical combination, & the universality of latter render spontaneous generation not improbable”. Like many of his contemporaries, Darwin rejected the idea that putrefaction of preexisting organ…
Optimal control with state constraints and the space shuttle re-entry problem
2003
In this article, we initialize the analysis under generic assumptions of the small \textit{time optimal synthesis} for single input systems with \textit{state constraints}. We use geometric methods to evaluate \textit{the small time reachable set} and necessary optimality conditions. Our work is motivated by the \textit{optimal control of the atmospheric arc for the re-entry of a space shuttle}, where the vehicle is subject to constraints on the thermal flux and on the normal acceleration. A \textit{multiple shooting technique} is finally applied to compute the optimal longitudinal arc.
A combination of algebraic, geometric and numerical methods in the contrast problem by saturation in magnetic resonance imaging
2014
In this article, the contrast imaging problem by saturation in nuclear magnetic resonance is modeled as a Mayer problem in optimal control. The optimal solution can be found as an extremal solution of the Maximum Principle and analyzed with the recent advanced techniques of geometric optimal control. This leads to a numerical investigation based on shooting and continuation methods implemented in the HamPath software. The results are compared with a direct approach to the optimization problem and implemented within the Bocop toolbox. In complement lmi techniques are used to estimate a global optimum. It is completed with the analysis of the saturation problem of an ensemble of spin particle…
Shaken Snow Globes: Kinematic Tracers of the Multiphase Condensation Cascade in Massive Galaxies, Groups, and Clusters
2018
We propose a novel method to constrain turbulence and bulk motions in massive galaxies, groups and clusters, exploring both simulations and observations. As emerged in the recent picture of the top-down multiphase condensation, the hot gaseous halos are tightly linked to all other phases in terms of cospatiality and thermodynamics. While hot halos (10^7 K) are perturbed by subsonic turbulence, warm (10^4 K) ionized and neutral filaments condense out of the turbulent eddies. The peaks condense into cold molecular clouds (< 100 K) raining in the core via chaotic cold accretion (CCA). We show all phases are tightly linked via the ensemble (wide-aperture) velocity dispersion along the line o…
The Contested Productivity of the Baker’s Body. Technology, Industrialization, and Labor in Nineteenth-Century France
2016
International audience; ...