Search results for "tecniche"
showing 10 items of 377 documents
Bioactive effects of citrus flavonoids and role in the prevention of atherosclerosis and cancer
2022
Citrus fruits are the main fruits of the Mediterranean diet and have been long recognized for their beneficial effects on human health. Observational studies have shown a significant association between dietary flavonoid intake and reduced risk of cardiovascular and malignant diseases. The beneficial effects of citrus fruits on human health appear to be due to their high content in vitamins, minerals and fibers. In particular, the antioxidant and anti-inflammatory activities have been indicated as some of the mechanisms through which citrus fruits may thwart the development of chronic degenerative diseases such as atherosclerosis and cancer. This review would critically examine the results …
Constructive characters of the Western Sicilian masonry in the XVIII and XIX centuries
2016
La tradizione costruttiva di apparecchi murari nella Sicilia occidentale - soprattutto a causa dei frequenti terremoti che si verificarono a Palermo tra i secoli XVIII-XIX (il più distruttivo avvenuto nel 1726, seguito da quelli del 1751, e 1823) - impose la realizzazione di nuovi tipi di muratura che, nel rispetto dei precetti della regola dell'arte, suggeriscono metodi più severi di quella che si può definire la "buona" costruzione muraria, sia nella scelta dei materiali che nell'adozione di nuove tecniche costruttive. La cultura tecnica di quel tempo era in grado di definire metodi costruttivi, introducendo appropriati miglioramenti e sperimentazioni, che promossero nuove conoscenze, tec…
La centrale elettrica Alessandro Volta. Conoscenza, recupero compatibile e pratiche di rigenerazione di un tassello di Patrimonio industriale a Paler…
2022
Palermo annovera un esempio di archeologia industriale lungo il waterfront davvero emblematico nell'ottica del riuso adattivo, delle buone pratiche di recupero compatibile e di rigenerazione dello spazio urbano: si tratta della Centrale elettrica Alessandro Volta, costruita dalla Schuckert & Co. di Norimberga nel 1899. Informazioni documentarie-archivistico-iconografiche reperite, nonché la permanenza pressoché immutata di alcuni corpi di fabbrica originari, consentono di attivare una ricerca applicata e progetto, ispirati ai suggerimenti della committente, agli indirizzi progettuali dell'Autorità portuale per la riqualificazione del waterfront, alle stringenti priorità europee in termi…
Esaltare gli aromi varietali con la tecnica enologica
2008
Osservazioni preliminari sulla tecnica attratticida e sugli effetti della sua combinazione con altre tecniche di controllo di Bactrocera oleae Gmellin
2005
The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape Programs
2021
Breast cancer (BC) mortality is mainly due to metastatic disease, which is primarily driven by cancer stem cells (CSC). The chemokine C-X-C motif ligand-1 (CXCL1) is involved in BC metastasis, but the question of whether it regulates breast cancer stem cell (BCSC) behavior is yet to be explored. Here, we demonstrate that BCSCs express CXCR2 and produce CXCL1, which stimulates their proliferation and self-renewal, and that CXCL1 blockade inhibits both BCSC proliferation and mammosphere formation efficiency. CXCL1 amplifies its own production and remarkably induces both tumor-promoting and immunosuppressive factors, includingSPP1/OPN,ACKR3/CXCR7,TLR4,TNFSF10/TRAILandCCL18and, to a lesser exte…
Selenium: A Cure for Autoimmune Thyroiditis.
2021
Autoimmune thyroiditis (AT) is a disease whose incidence has increased dramatically over the past few decades. In iodine sufficient areas, this pathological condition affects up to 5% of the general population. The higher incidence of AT observed in areas of the world with low-selenium (Se) soils apperas to be the consequence of a reduced activity of the intracellular Sedependent glutathione peroxidase activity. Se is involved, through selenoproteins, in the regulation of intracellular antioxidant, redox and anti-inflammatory processes. As a component of selenoproteins, Se exerts various structural and enzymatic functions. A low Se/high fat diet can cause selenoprotein changes and promote t…
A perspective analysis: microRNAs, glucose metabolism, and drug resistance in colon cancer stem cells
2021
Metabolism sustains the stemness of Cancer Stem Cells (CSCs), affecting, in turn, tumor heterogeneity, metastatic potential, and therapy resistance. Therefore, it is appealing to target CSCs metabolism as a new therapeutic approach. Consequently, we paid considerable attention to the anti-apoptotic microRNA miR-483-3p, that we reported being regulated by glucose metabolism in liver cancer cells. We investigated the therapeutic potential of targeting miR-483-3p by using the anti-glucose metabolism 2-deoxyglucose (2-DG) molecule in tumor Xenograft mouse model originating from two different Colon-Cancer Stem Cell lines (CCSC lines). We show that 2-DG treatment does not affect CCSCs during tumo…
Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
2021
ABSTRACT Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.
Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51
2022
AbstractBreast cancer (BC) is the second cause of cancer-related deceases in the worldwide female population. Despite the successful treatment advances, 25% of BC develops resistance to current therapeutic regimens, thereby remaining a major hurdle for patient management. Current therapies, targeting the molecular events underpinning the adaptive resistance, still require effort to improve BC treatment. Using BC sphere cells (BCSphCs) as a model, here we showed that BC stem-like cells express high levels of Myc, which requires the presence of the multifunctional DNA/RNA binding protein Sam68 for the DNA-damage repair. Analysis of a cohort of BC patients displayed that Sam68 is an independen…