Search results for "temi"
showing 10 items of 3194 documents
The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus
2021
International audience; Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings, but, behind these common features, there are different pathogenic mechanisms, immune cells dysfunctions, and targeted organs. In this context, multiple lines of evidence suggest the application of precision medicine principles to AIDs to reduce the treatment failure. Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient, thus it could be a new approach for management of AIDS which considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in ch…
Interleukin-9 and T helper type 9 cells in rheumatic diseases
2016
Summary Interleukin (IL)-9 is a 28-30 kDa monomeric glycosylated polypeptide belonging to the IL-7/IL-9 family of proteins that bind to a composite receptor consisting of the private receptor IL-9R and the IL-2 receptor, gamma (IL-2RG), a common gamma subunit shared by the receptors of many different cytokines. The IL-9R is expressed widely and IL-9 impacts a number of effector cells, such as effector T cells, B cells, innate lymphoid cells, mast cells, polymorphonuclear cells, epithelial cells and smooth muscle cells, playing an important role in regulating inflammatory immunity. The critical role of IL-9 in promoting cellular and humoral immune responses makes it an important focus of pot…
Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders
2015
The pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community, Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons for this include lack of sensitivity/specificity of current screening methods, lack of reliable screening tests for some pathogens (e.g. prions) and the fact that many potentially harmful infectious agents are not routinely screened for. Methods for the purification/inactivation of blood/plasma-derived products have been developed in order to further reduce the residual risk, but low concentrations…
Synthesis and cytotoxic activity of new artemisinin hybrid molecules against human leukemia cells
2017
A series of new artemisinin-derived hybrids which incorporate cholic acid moieties have been synthesized and evaluated for their antileukemic activity against sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 cells. The new hybrids 20-28 showed IC50 values in the range of 0.019µM-0.192µM against CCRF-CEM cells and between 0.345µM and 7.159µM against CEM/ADR5000 cells. Amide hybrid 25 proved the most active compound against both CCRF-CEM and CEM/ADR5000 cells with IC50 value of 0.019±0.001µM and 0.345±0.031µM, respectively. A relatively low cross resistance to hybrids 20-28 in the range of 5.7-fold to 46.1-fold was measured. CEM/ADR5000 cells showed higher resistance than CCRF-CEM to al…
Beyond malaria: The inhibition of viruses by artemisinin-type compounds
2018
Abstract Natural products represent valuable chemical scaffolds for drug development. A recent success story in this context was artemisinin, which is not only active against malaria but also to other diseases. This raised the interest of artemisinin's potential for drug repurposing. On the present review, we give an overview on artemisinin's antiviral activity. There is good in vitro and in vivo evidence for the activity of artemisinin and its derivatives against DNA viruses of the Herpesviridae and Hepadnaviridae families such as cytomegaloviruses, human herpesvirus 6, herpes simplex viruses 1 and 2, Epstein-Barr virus and Hepatitis B virus. The evidence is weaker for Polyomaviruses and p…
NMR Exchange Format: a unified and open standard for representation of NMR restraint data
2015
SCOPUS: le.j
Systemic Risk in a Structural Model of Bank Default Linkages
2018
Abstract We study a structural model of individual bank defaults across the banking sector; banks are interconnected through their exposure to a common risk factor. The paper introduces a systemic risk measure based on the default frequency in the banking sector; this measure depends non-linearly on the factor's loadings, in contrast to previous systemic risk measures that depend linearly on loadings. We estimate loadings in the U.S. banking system over the course of the last 36 years; we find that they have considerably increased over time and identify four major regimes. Our measure shows that systemic risk became critical in the last of our four regimes, covering the most recent time per…
Systemic support and environmental awareness in a normalised environmental management system consistent with ISO 14001
2021
PurposeThe study aimed to determine the correlations occurring between systemic support and environmental awareness. Additionally, the authors wished to establish which systemic factors (criteria of the ISO 14001) impact those dependencies.Design/methodology/approachQuantitative and qualitative research were carried out (survey findings were analysed against documentation research and self-observation records). The authors used literature review, analysis of system documentation, survey research and self-observation. The research was conducted in the period from April to May 2020. It focused on a chemical company operating within the structure of a large capital group and employing over 1,5…
Selves, interactive representations and context
2021
Abstract In this paper, I re-examine the notion of ‘clause-as-representation’ in Michael Halliday’s systemic functional theory of language. I argue that ‘representation’ is a mode of linguistic action that cannot be understood in terms of the experiential metafunction alone. Instead, a theoretical account of representation must be undertaken in relation to all the metafunctions. Rejecting encodingist accounts of representation, I develop the argument that representations are interactively constituted and emergent in languaging activity. The paper develops these arguments in relation to a process ontological account of the relations between language and the world-side phenomena that language…
Attention-based Model for Evaluating the Complexity of Sentences in English Language
2020
The automation of text complexity evaluation (ATCE) is an emerging problem which has been tackled by means of different methodologies. We present an effective deep learning- based solution which leverages both Recurrent Neural and the Attention mechanism. The developed system is capable of classifying sentences written in the English language by analysing their syntactical and lexical complexity. An accurate test phase has been carried out, and the system has been compared with a baseline tool based on the Support Vector Machine. This paper represents an extension of a previous deep learning model, which allows showing the suitability of Neural Networks to evaluate sentence complexity in tw…