Search results for "temi"
showing 10 items of 3194 documents
Internal Simulation of an Agent’s Intentions
2013
We present the Associative Self-Organizing Map (A-SOM) and propose that it could be used to predict an agent’s intentions by internally simulating the behaviour likely to follow initial movements. The A-SOM is a neural network that develops a representation of its input space without supervision, while simultaneously learning to associate its activity with an arbitrary number of additional (possibly delayed) inputs. We argue that the A-SOM would be suitable for the prediction of the likely continuation of the perceived behaviour of an agent by learning to associate activity patterns over time, and thus a way to read its intentions.
Potential feasibility of atezolizumab-bevacizumab therapy in patients with hepatocellular carcinoma treated with tyrosine-kinase inhibitors
2022
Background: The combination of atezolizumab-bevacizumab has been proven to be superior to sorafenib for the treatment of unresectable hepatocellular carcinoma not amenable to locoregional treatments, be-coming the standard of care of systemic therapy.Aim: This study aimed at assessing real-world feasibility of atezolizumab-bevacizumab in patients treated with tyrosine-kinase inhibitors.Methods: Among 1447 patients treated with tyrosine-kinase inhibitors from January 2010 to December 2020, we assessed the percentage of those potentially eligible to atezolizumab-bevacizumab (according to IMbrave-150 trial criteria), and the overall survival of eligible and non-eligible patients.Results: 422 (…
Awareness and Partitional Informational Structures
1997
We begin with an example to motivate the introduction of the concept of unawareness in models of information. There are a subject and two possible states of the world, σ and τ. At σ a certain fact p happens — it is true — and the subject sees it or hears it or anyhow perceives it, so that he knows it is true (in Geanakoplos [5] the subject is Sherlock Holmes’ assistant and fact p is ‘the dog barks’). At state τ fact p does not occur (it is false), and the subject not only does not see it or hear it etc.; but what is more, he does not even think of the possibility that it might: fact p is not present to the subject’s mind. What is an appropriate formal model for this story?
Fuzzy Fusion in Multimodal Biometric Systems
2007
Multimodal authentication systems represent an emerging trend for information security. These systems could replace conventional mono-modal biometric methods using two or more features for robust biometric authentication tasks. They employ unique combinations of measurable physical characteristics: fingerprint, facial features, iris of the eye, voice print, hand geometry, vein patterns, and so on. Since these traits are hardly imitable by other persons, the aim of these multibiometric systems is to achieve a high reliability to determine or verify person's identity. In this paper a multimodal biometric system using two different fingerprints is proposed. The matching module integrates fuzzy…
Genetics and novel aspects of therapies in systemic lupus erythematosus.
2015
Autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, autoimmune hepatitis and inflammatory bowel disease, have complex pathogeneses and the factors which cause these disorders are not well understood. But all have in common that they arise from a dysfunction of the immune system, interpreting self components as foreign antigens. Systemic lupus erythematosus (SLE) is one of these complex inflammatory disorders that mainly affects women and can lead to inflammation and severe damage of virtually any tissue and organ. Recently, the application of advanced techniques of genome-wide scanning revealed more genetic information about SLE than previously possible. These case-contro…
PS5:100 Patophysiological role of type i and iii interferons in systemic lupus erythematosus (sle)
2018
Systemic Lupus erythematosus (SLE) is an autoimmune disease characterised by activated autoreactive lymphocytes and autoantibodies, resulting in tissue damage in multiple organs. An important factor for the disease´s mortality is the development of Lupus nephritis (LN). Type I and III interferons, which are both part of the antiviral defense, have both been associated with the disease´s activity. In sera and urine of SLE patients an enhanced level of IL28/29 was described, but their distinct functional role in the course of disease need to be further investigated. To determine the role of type I and III interferons during onset and progression of autoimmunity – with focus on the development…
Autoimmune ear disease: clinical and diagnostic relevance in Cogan’s sydrome
2017
The autoimmune inner ear disease is a clinical syndrome with uncertain pathogenesis that is often associated to rapidly progressive hearing loss that, especially at the early stages of disease, may be at monoaural localization, although more often it is at binaural localization. It usually occurs as a sudden deafness, or a rapidly progressive sensorineural hearing loss. In this study a particular form of autoimmune inner ear disease is described, Cogan’s syndrome. Cogan’s syndrome is a chronic inflammatory disorder that most commonly affects young adults. Clinical hallmarks are interstitial keratitis, vestibular and auditory dysfunction. Associations between Cogan’s syndrome and systemic va…
Assessing the electricity consumption of outdoor lighting systems in the presence of automatic control: The OL-BAC factors method
2020
Abstract Building automation systems are able to influence significantly buildings’ energy performance. The BAC factors method, presented for the first time by the International Standard EN 15232, is the most used and simple instrument for evaluating the impact of such systems in terms of reduction of the electrical and thermal energy consumption of buildings services. Nevertheless, Standard EN 15232 does not take into consideration the automation of lighting systems serving buildings’ external areas like passages, gardens, entrance walkways, etc. In some cases, such areas can be very extended and, as a consequence, responsible for a not negligible percentage of the overall electricity cons…
Come valutare i risultati scolastici : modelli a confronto
2006
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Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production
2011
The antimalarial agent artesunate (ART) activates programmed cell death (PCD) in cancer cells in a manner dependent on the presence of iron and the generation of reactive oxygen species. In malaria parasites, ART cytotoxicity originates from interactions with heme-derived iron within the food vacuole. The analogous digestive compartment of mammalian cells, the lysosome, similarly contains high levels of redox-active iron and in response to specific stimuli can initiate mitochondrial apoptosis. We thus investigated the role of lysosomes in ART-induced PCD and determined that in MCF-7 breast cancer cells ART activates lysosome-dependent mitochondrial outer membrane permeabilization. ART impac…