Search results for "temi"

Preclinical models for colonic absorption, application to controlled release formulation development.

2018

Oral controlled release (CR) formulations have many benefits and have become a valuable resource for the local and systemic administration of drugs. The most important characteristic of these pharmaceutical products is that drug absorption occurs mainly in the colon. Therefore, this review analyses the physiological and physicochemical features that may affect an orally administered CR product, as well as the different strategies to develop a CR dosage form and the methods used to evaluate the formulation efficacy. The models available to study the intestinal permeability and their applicability to colonic permeability determinations are also discussed.

The Development of Spatial Location in Finnish

1991

Abstract The purpose of this research was to study the shift from mono- to bi-referential spatial location in the language of Finnish children. Monoreferential location is based on the intrinsic properties of a referent object and the proximity relationship, and bireferential location requires coordinated spatial relationships involving referent objects and a projective relationship. Locative expressions which are monoreferential include: in/on/under and intrinsic front/back, and those which are bireferential include deictic front/back and between. A pictorial representation of locative relationships with a sentence-picture matching task was used to present the mono- vs bi-referential contr…

Evidence for the presence of autoantibodies to the collagen-like portion of C1q in systemic lupus erythematosus.

1988

We investigated the connection between the C1q solid-phase binding assay (C1q SPBA) and double-stranded DNA antibodies, and analyzed the immune complex material in systemic lupus erythematosus (SLE) sera. Comparison with a new monoclonal assay for C1q-bearing immune complexes (the 242G3 assay) revealed that the immune complexes in SLE bind specifically to solid-phase C1q, and not to fluid-phase C1q. The C1q solid-phase binding activity sedimented as 7S IgG, was insensitive to DNase treatment, and could be selectively absorbed by C1q-coupled beads and by bovine serum albumin-anti-bovine serum albumin C1q beads, but not by DNA. Thus, antibodies to double-stranded DNA do not interfere in the C…

Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours.

2009

Scientific progress in genetics, cell and molecular biology has greatly ameliorated our comprehensive understanding of the molecular mechanisms of neoplastic transformation and progression. The rapidly advancing identification of molecular targets in human cancers during the last decade has provided an excellent starting point for the development of novel therapeutics. A huge variety of potential molecular targets have been identified, many of which are already in the market for therapeutic purposes. It is now becoming possible to target pathways and/or molecules that are crucial in maintaining the malignant phenotype. Traditional Chinese medicine (TCM) is often considered as alternative or…

Apresentação

2018

L'articolo confronta il sistema educativo 0-6 italiano e brasiliano, alla luce delle nuove normative e dell'idea di qualità educativa sottostante. Presenta successivamente,in termini critici e riflessivi, gli articoli contenuti nel numero monografico sulla "Valutazione di contesto", di ricercatori italiani e brasiliani, ricavando una sintesi che problematizza e apre nuove prospettive The article compares Italian and Brazilian 0-6 education system, considering the new laws and the underlying idea of educational quality. It then presents, in critical and reflective terms, the papers in the monographic issue on "Educational Evaluation", from Italian and Brazilian researchers, obtaining a synth…

Approximated overlap error for the evaluation of feature descriptors on 3D scenes

2013

This paper presents a new framework to evaluate feature descriptors on 3D datasets. The proposed method employs the approximated overlap error in order to conform with the reference planar evaluation case of the Oxford dataset based on the overlap error. The method takes into account not only the keypoint centre but also the feature shape and it does not require complex data setups, depth maps or an accurate camera calibration. Only a ground-truth fundamental matrix should be computed, so that the dataset can be freely extended by adding further images. The proposed approach is robust to false positives occurring in the evaluation process, which do not introduce any relevant changes in the …

Editorial Note The path of complexity science: from theory to managerial practice

2012

The application of complexity science to business has always been a diicult task because it is not easy to demonstrate the relevance of complexity theories to practicing managers. We accepted this challenge with this Special Issue, and I think we are giving a good con- tribution in this sense.

Optimal design of flax fiber reinforced polymer composite as a lightweight component for automobiles from a life cycle assessment perspective

2019

The present study combines the generalized rule-of-mixture (ROM) model and the Ashby material selection method for the life cycle assessment (LCA) of flax fiber reinforced polymers (FRPs) and glass FRPs (GFRPs). The ROM model allows life cycle environmental impact predictions according to specific parameters of flax FRPs such as fiber format, volume fraction, manufacturing technique, and load-bearing capacity. The comparisons applied in this study are constructed on two common composite structures: mat panels and injection molded struts with equal stiffness and strength as the design criteria. On the one hand, the parametric LCA predicts that the equal strength design criterion for flax FRP…

Software Architectures for Human-Machine Interaction Using Natural Language

Il linguaggio naturale rappresenta un sistema di comunicazione a carattere inferenziale in opposizione ai sistemi di comunicazione a codice che non prevedono una forma di ragionamento intelligente da parte del ricevente, ma si basano sul riconoscimento di patterns dell'informazione. In un sistema di comunicazione di tipo inferenziale, infatti, si parte dal presupposto che il ricevente abbia una certa "intelligenza" e sia, quindi, capace di comprendere, elaborare ed inferire il contenuto informativo di una comunicazione attraverso ragionamenti su un background di conoscenze (come modelli di mondo e di linguaggio) condivisi sia dalla sorgente che dal destinatario. L'attività di ricerca, svolt…

Creation and cognition for humanoid live dancing

2016

Abstract Computational creativity in dancing is a recent and challenging research field in Artificial Intelligence and Robotics. We present a cognitive architecture embodied in a humanoid robot capable to create and perform dances driven by the perception of music. The humanoid robot is able to suitably move, to react to human mate dancers and to generate novel and appropriate sequences of movements. The approach is based on a cognitive architecture that integrates Hidden Markov Models and Genetic Algorithms. The system has been implemented on a NAO robot and tested in public setting-up live performances, obtaining positive feedbacks from the audience.