Search results for "terce"
showing 10 items of 394 documents
Mundialización y posmodernidad
1998
The role of oxidative stress in pro-inflammatory activation of human endothelial cells on Ti6Al4V alloy
2013
Inflammation is an important step in the early phase of tissue regeneration around an implanted metallic orthopaedic device. However, prolonged inflammation, which can be induced by metallic corrosion products, can lead to aseptic loosening and implant failure. Cells in peri-implant tissue as well as metal corrosion can induce reactive oxygen species (ROS) formation, thus contributing to an oxidative microenvironment around an implant. Understanding cellular reactions to implant-induced oxidative stress and inflammatory activation is important to help prevent an adverse response to metallic materials. In an earlier study we have shown that endothelial cells grown on Ti6Al4V alloy are subjec…
The fine structure of de-and reinnervated muscle spindles
1974
Reinnervated muscle spindles in lower lumbrical muscles of rats studied 17 days to 24 months after crushing the sciatic nerve showed a series of alterations which have not been analysed, thus far, by electron microscopy. There was a striking increase of the number of intrafusal muscle fibers seen in approximately 20% of reinnervated spindles. These spindles showed 5–11 intrafusal muscle fibers whereas normal spindles usually contained 3–4 fibers only.
Expression analysis of jagged genes in zebrafish embryos
2005
The interaction of transmembrane Delta and Jagged/Serrate ligands with Notch receptors on neighboring cells is critically involved in cell specification during development. In zebrafish, the early expression of delta but not of jagged genes has been investigated in some detail. We have analyzed the sequence and embryonic expression pattern of the three zebrafish genes jagged1a, jagged1b, and jagged2. These genes, whose transcripts are detectable by in situ hybridization from early somitogenesis, are widely and dynamically expressed in embryos. Coexpression is limited, however, to the notochord and lens (jagged1a and jagged1b) and to the otic vesicle and pronephros (jagged1b and jagged2). Co…
Emerging Therapeutic Strategies for Traumatic Spinal Cord Injury
2020
Spinal cord injury (SCI) is a debilitating neurologic condition with tremendous socioeconomic impact on affected individuals and the health care system. The treatment of SCI principally includes surgical treatment and marginal pharmacologic and rehabilitation therapies targeting secondary events with minor clinical improvements. This unsuccessful result mainly reflects the complexity of SCI pathophysiology and the diverse biochemical and physiologic changes that occur in the injured spinal cord. Once the nervous system is injured, cascades of cellular and molecular events are triggered at varying times. Although the cascade of tissue reactions and cell injury develops over a period of days …
A combined ex/in vivo assay to detect effects of exogenously added factors in neural stem cells.
2007
We describe a protocol developed/modified by our group for the ex vivo and in vivo assessment of the response to a soluble factor of murine neural stem cells from the adult sub-ventricular zone (SVZ). The procedure includes several experimental options that can be used either independently or in combination. Potential factor effects on self-renewal, survival and proliferation are assayed by means of neurosphere cultures, with the factor administered directly in vitro to the culture plates (Step 1) or infused in vivo immediately before tissue dissociation (Step 3). We also use bromodeoxiuridine (BrdU) retention to label slowly dividing cells in vivo and subsequently perform two different typ…
Effects of transdermal hormone replacement therapy on levels of soluble P- and E-selectin in postmenopausal healthy women
2002
Abstract Objective: To study the adhesion molecule pattern in postmenopausal women who were not receiving hormone replacement therapy (HRT), HRT users, and fertile women. Design: Case-control study. Setting: Second University of Naples, Naples, Italy. Patient(s): Fifty healthy naturally postmenopausal women and 20 fertile women. Intervention(s): Twenty-six women received no HRT and 24 received continuous transdermal 17β−estradiol, 0.05 mg/d, plus oral acetate nomegestrol, 5 mg/d. Main Outcome Measure(s): Levels of the soluble forms of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, and P-selectin. Result(s): Women who did not received HRT …
Migrantes, refugiados y tercer sector social. Un análisis del papel de las grandes ONG españolas en la gestión de fondos y políticas
2022
Introducción. A lo largo de los últimos años España ha visto incrementar su población inmigrante y refugiada, lo que ha planteado nuevas necesidades en cuanto a su atención e integración. En gran medida, esta tarea ha recaído en las Organizaciones No Gubernamentales con la financiación del Estado, algo que también habría sucedido en otros países europeos afectados por la crisis de los sistemas de bienestar en mayor o menor medida. Metodología. Con el fin de obtener datos al respecto, hemos procedido a consultar la base de datos de subvenciones del Estado y las resoluciones de las convocatorias del Ministerio de Inclusión, Migraciones y Seguridad Social en relación con la financiación recibi…
Las organizaciones no gubernamentales de desarrollo en España. Una nueva radiografía sobre su perfil y tipología en el contexto del Tercer Sector
2022
Las organizaciones no gubernamentales de desarrollo se han convertido en actores fundamentales de la coo peración internacional y han adquirido, a lo largo de los años, un papel destacado en la sociedad civil española. El objetivo de este artículo es mostrar el perfil actual de las ONGD en nuestro país. Para ello, empleamos los da tos obtenidos a partir de una amplia encuesta realizada dentro de un proyecto de investigación financiado por la convocatoria Retos de la Sociedad en el año 2016. Los resultados de dicha encuesta nos han permitido construir una tipología que da cuenta de la diversidad del campo de las ONGD, a diferencia de otros estudios previos que mostraron un sector mucho más c…
New neurons follow the flow of cerebrospinal fluid in the adult brain
2006
Autores: Sawamoto, K. et al. .- PMID:16410488