Search results for "terce"
showing 10 items of 394 documents
LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming.
2010
AbstractA key event in the successful induction of adaptive immune responses is the antigen-specific activation of T cells by dendritic cells (DCs). Although LFA-1 (lymphocyte function–associated antigen 1) on T cells is considered to be important for antigen-specific T-cell activation, the role for LFA-1 on DCs remains elusive. Using 2 different approaches to activate LFA-1 on DCs, either by deletion of the αL-integrin cytoplasmic GFFKR sequence or by silencing cytohesin-1–interacting protein, we now provide evidence that DCs are able to make use of active LFA-1 and can thereby control the contact duration with naive T cells. Enhanced duration of DC/T-cell interaction correlates inversely …
D2R striatopallidal neurons inhibit both locomotor and drug reward processes.
2009
The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.
Signalling molecules and growth factors for tissue engineering of cartilage-what can we learn from the growth plate?
2009
Modern tissue engineering concepts integrate cells, scaffolds, signalling molecules and growth factors. For the purposes of regenerative medicine, fetal development is of great interest because it is widely accepted that regeneration recapitulates in part developmental processes. In tissue engineering of cartilage the growth plate of the long bone represents an interesting, well-organized developmental structure with a spatial distribution of chondrocytes in different proliferation and differentiation stages, embedded in a scaffold of extracellular matrix components. The proliferation and differentiation of these chondrocytes is regulated by various hormonal and paracrine factors. Thus, mem…
Electron Microscopic Contrast of the Cytoskeleton and Junctional Complexes of Intestinal Epithelial Cells by Ethanolic Phosphotungstic Acid
2000
After glutaraldehyde fixation and treatment with ethanolic phosphotungstic acid (E-PTA) before plastic embedding, sections of rat large intestine showed a characteristic electron contrasting pattern in epithelial cells. The axis of microvilli, terminal web, a thin band below the luminal plasma membrane, centrioles and junctional complexes (tight junctions, adherens junctions, and desmosomes) appeared highly contrasted. In addition to protein components of microfilaments and intermediate filaments, proteins from the junctional complexes could also be implicated in the contrasting reaction with E-PTA. Mitochondrial membranes, chromatin masses, and nucleoli of enterocytes showed considerable e…
La práctica narrativa desde el Trabajo Social: su abordaje en contextos profesionales de acción social. Estudio en el marco de la estrategia metodoló…
2017
La Tesis tiene como objetivo revisar el método de trabajo de los trabajadores sociales para incorporar nuevos saberes que se ajusten más a las necesidades de nuestros usuarios, que les den más el protagonismo pues nadie sabe más de su historia que ellos mismos. Partimos de una visión de la intervención desde otro paradigma, en donde el lenguaje ocupe un lugar central; situándonos en la crítica posmoderna. La tesis se articula en torno a la idea de gestionar Prácticas de reciprocidad, entre los profesionales de la Acción Social y los consultantes que acuden a los servicios sociales y también en los servicios del tercer sector subsidiarios a los servicios sociales públicos. Es a partir de la …
Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid
2004
E-selectin mediated tumor cell adhesion plays an important role in metastasis. Here we show that ionizing radiation (IR) induces E-selectin gene and protein expression in human endothelial cells at therapeutically relevant dose level. E-selectin expression is accompanied by an increase in the adhesion of human colon carcinoma cells to primary human umbilical vein endothelial cells (HUVEC). The HMG-CoA reductase inhibitor lovastatin impairs IR-stimulated E-selectin expression as analyzed at the level of the protein, mRNA and promoter. Inactivation of Rho GTPases either by use of Clostridium difficile toxin A or by co-expression of dominant-negative Rho blocked IR-induced E-selectin gene indu…
Collecte des données Véhicule/Environnement et remontée avec réseau Cellulaire et réseau Véhiculaire
2019
Vertical handover is one of the key technologies that will facilitate the connected and autonomous vehicles deployment. Today, the emergence of Vehicular Ad hoc Networks (VANETs): Vehicle-to-Vehicle (V2V) communications, Vehicle-to-Infrastructure (V2I) and Vehicle-to-Everything (V2X) has enabled new applications such as Cooperative Intelligent Transport Systems (C-ITS), real-time applications (for example, autonomous driving), road traffic management applications and comfort applications. However, these networks are characterized by a high level of mobility and dynamic change in the topology, which generates scattered networks and requires handover mechanisms for maintaining ongoing session…
La cúpula de la Basílica de la Virgen de los Desamparados de Valencia (I): el ámbito de la gloria
2007
-Rafael.G-Mahiques@uv.es Estudio iconográfico de los frescos de la cúpula de la Basílica de la Virgen de los Desamparados de Valencia, obra de Antonio Palomino realizada entre 1701 y 1704. Aproximación a un análisis del ámbito de la Gloria celestial. Aquí la Virgen aparece como reina e intercesora ante el Trono de Gracia, en donde, de acuerdo con la tradición iconográfica, se incluye a San Juan Bautista y los arma Christi portados por ángeles. En torno a este núcleo se disponen los bienaventurados, agrupados bajo el criterio de la Letanía Lauretana, en la cual María es invocada con los títulos de Reina de los Ángeles, de los Patriarcas, Profetas, Apóstoles, Mártires, Confesores, Vírgenes y …
Estudio de la organización celular y capacidad proliferativa en el tercer ventrículo de mamíferos adultos.
2016
Los tanicitos son células epiteliales que tapizan el tercer ventrículo del cerebro y envían un proceso basal hacia los núcleos neuronales hipotalámicos implicados en la regulación de diversas funciones endocrinas. Ese proceso basal le confiere apariencia de glía radial, célula de la que procede, contactando con la piamadre y capilares fenestrados. En el cerebro de ratón adulto, los tanicitos hipotalámicos, quiescentes en condiciones basales, proliferan in vitro e in vivo tras administración de dietas ricas en grasas, o por la adición intracerebroventricular de factores de crecimiento. Hasta la fecha los tanicitos se han clasificado en base a la localización que ocupan en la pared del 3V cor…
(Re-)examining horizons in feminist translation studies: towards a third wave
2009
This article is an English version of "(Re)examinando horizontes en los estudios feministas de traducción: ¿hacia una tercera ola?" by Olga Castro, which was first published in MonTI 1 (2009), pp. 59-86. It was not included on the print version of MonTI for reasons of space. The online version of MonTI does not suffer from these limitations, and this is our way of promoting plurilingualism and internationalism. Feminisms are one of those framework theories that have contributed powerfully to all areas of society, including Translation Studies. The most evident outcome of this interplay is the emergence, in the 1980s, of a Feminist Translation school in Canada, which placed gender in the spo…