Search results for "testi"
showing 10 items of 4607 documents
2020
In this study, the potential for correlation between disintegration and dissolution performance of enteric-coated (EC) dosage forms was investigated. Different enteric hard shell capsule formulations containing caffeine as model drug were tested for disintegration (in a compendial disintegration tester) and for dissolution in both USP type I (basket) and type II (paddle) apparatuses using different media. Overall, good correlations were obtained. This was observed for both the basket and the paddle apparatus, indicating that the use of disintegration testing as a surrogate for dissolution testing (allowed by International Conference on Harmonization (ICH) for immediate release dosage forms …
Effects of polysorbate 80 on amiodarone intestinal absorption in the rat
1995
Abstract Amiodarone is a widely used anti-arrhythmic agent which shows physico-chemical properties that are highly suitable for diffusion across lipophilic absorbing membranes, however,.its low aqueous solubility could represent the rate-limiting step for absorption, making it erratic and variable. In a previous paper, the influence of an anionic surfactant (sodium lauryl sulphate) at variable supramicellar concentrations was studied. The absorption rate constants of amiodarone decreased as the surfactant concentration increased, and absorption was unusually fast at lower surfactant concentrations. The previously proposed equations for interpreting the relationships between the amiodarone a…
Multicomponent solid dispersion as a formulation strategy to improve drug permeation: A case study on the anti-colorectal cancer irinotecan
2019
Abstract Multicomponent solid dispersions (MSD)s are frequently proposed as efficient drug delivery systems to improve drug solubility and bioavailability. In this study, the effects of specific excipients, such as mannitol, inulin, poly(methyl methacrylate-co-methacrylic)acid (PMMA) and cellulose acetate phthalate (CAP) have been tested to potentially improve irinotecan (IRN) permeation in the intestinal tract with the intention to protect the drug from the gastric environment. MSDs were formulated as microparticles by Spray-Drying technique. Raw materials and microparticles have been characterized by FTIR analysis to determine hydrogen bonding. SEM images were recorded to investigate morp…
Semiquantitative multiplex PCR: a useful tool for large rearrangement screening and characterization
2006
Methods presently employed for detection of large rearrangements have several drawbacks, such as the amount of sample and time required, technical difficulty, or the probability of false-negative carriers. Using the low-density-lipoprotein receptor (LDLR) gene, whose mutations are responsible for familial hypercholesterolemia (FH), we have developed a procedure to detect large rearrangements in this gene based on semiquantitative PCR, with important improvements as compared to previous methods. Our method covers the complete LDLR gene and introduces an internal control in the reaction. The procedure discriminates the four different large rearrangements (two deletions and two insertions) tha…
Relationship status and respiratory diseases: an analysis on a general population sample
2021
Background: Very few studies have examined whether marital/relationship status affects respiratory diseases. Objective: Assess the association of relationship status (Rstatus: domestic partnership/civil union/marriage, cohabitation with non-partners, being single) with current (CA) and past asthma (PA), allergic (AR) and non-allergic rhinitis (NAR), and chronic bronchitis (CB). Methods: Data were collected in the frame of GEIRD, a population-based, multicase-control survey. Among 2531 subjects (age 21–86, female 50%) who underwent standardized interviews, skin prick and lung function tests, 575 cases of CA, 268 cases of PA, 968 cases of AR, 462 cases of NAR, 265 cases of CB without airflow …
Enhanced CiTNFα expression is an inflammatory response of the ascidian Ciona intestinalis
2009
La representación y lo inhumano. Sobibor. 14 octobre 1943, 16 heures (C. Lanzmann)
2007
Los problemas y límites de la representación de fenómenos extremos adquieren especial relevancia cuando éstos proceden, no de la imaginación narrativa o espectacular, sino de acontecimientos reales tratados en soporte documental. Ninguno de estos fenómenos ha generado tanta bibliografía como la Shoah, calificada a menudo de irrepresentable e inefable. El presente artículo estudia Sobibor: 14 octobre 1943, 16 heures (Claude Lanzmann, 2001), constituido por una sola entrevista realizada a Yehuda Lerner, superviviente de la sublevación del campo de exterminio de Sobibor. El análisis se realiza a la luz de los criterios de representabilidad, en su poética de rechazo al documento de archivo y en…
Lo schermo trasparente : cinema e città
2022
Il libro affronta come interpretare e comprendere i luoghi, le pratiche urbane, il ruolo del potere e le culture territoriali sia possibile anche tramite la “fonte non convenzionale” del cinema che, insieme alla fotografia, dal XIX secolo può servire per esplorare in modo dettagliato contesti geografici e territoriali, a volte completando altre confutando le informazioni degli archivi tradizionali, ma di certo entrando a far parte della memoria e dell’immaginario collettivi. Il libro enuncia una vera e propria teoria con le sue regole e i suoi esempi, dall’opera di autori della nostra storia culturale come Ciprì e Maresco, Francesco Rosi e Pier Paolo Pasolini, fino a casi più recenti e ugua…