Search results for "therapies"
showing 4 items of 124 documents
Novel cytokine-targeted therapies and intestinal inflammation
2009
Several cytokines have been identified as critical mediators of chronic inflammation in inflammatory bowel disease (IBD) and biological therapies that target these molecules have been developed during recent years. Thereby, anti-TNF agents have noticeably improved the treatment of patients with IBD in comparison to conventional therapy. Furthermore, initial clinical trials showed promising results with anti-IL-6 and anti-IL-12/IL-23 agents. In addition to these well-known mediators of IBD, various novel cytokines have been described as critical during the pathogenesis of IBD in recent experimental studies and therapeutic targeting of these cytokines could provide new strategies for human di…
Antioxidant Therapies and Oxidative Stress in Friedreich´s Ataxia: The Right Path or Just a Diversion?
2020
Friedreich's ataxia is the commonest autosomal recessive ataxia among population of European descent. Despite the huge advances performed in the last decades, a cure still remains elusive. One of the most studied hallmarks of the disease is the increased production of oxidative stress markers in patients and models. This feature has been the motivation to develop treatments that aim to counteract such boost of free radicals and to enhance the production of antioxidant defenses. In this work, we present and critically review those 'antioxidant' drugs that went beyond the disease's models and were approved for its application in clinical trials. The evaluation of these trials highlights some …
Impacto científico en los artículos sobre aplicaciones terapéuticas de las prácticas orientales cuerpo-mente (2006-2010)
2014
Global research on mind-body therapies is analysed, by focussing on scholarly articles on three Eastern disciplines (yoga, tai chi and qi gong) and three procedures (meditation, breathing exercises and relaxation). The bibliographic research was done using the Scopus database. The search was limited to the biomedical areas and to the years 2006-2010. We have analysed 2,363 articles published by 959 different journals. They were written by 6,583 authors from 2,162 institutions in 65 countries. Indicators of scientific productivity and impact were calculated for institutions, countries and subject areas, and the collaboration between authors and institutions was also determined. We have obser…
Internalization of novel non-viral vector TAT-streptavidin into human cells
2007
BMC Biotechnology, 7 (1)