Search results for "throughput"

Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs

2012

Hepatotoxicity is a major reason for drug nonapprovals and withdrawals. The multiparametric analysis of xenobiotic toxicity at the single cells level using flow cytometry and cellular imaging-based approaches, such as high-content screening (HCS) technology, could play a key role in the detection of toxicity and the classification of compounds based on patterns of cellular injury. This study aimed to develop and validate a practical, reproducible, in vitro multiparametric cell-based protocol to assess those drugs that are potentially hepatotoxic to humans and to suggest their mechanisms of action. The assay was applied to HepG2 human cell line cultured in 96-well plates and exposed to 78 di…

The EU's New Economic Governance Framework and Budgetary Decision‐Making in the Member States: Boon or Bane for Throughput Legitimacy?*

2021

The euro crisis has sparked changes in the EU's economic governance framework and a crisis of legitimacy across the union. While the institutional repercussions of the crisis have been studied before, the democratic impact at the national level has received much less attention. This paper aims to fill this gap, focusing on the procedural changes that the EU's new economic governance (NEG) framework has brought to national budgetary decision-making. Building upon the Varieties of Democracy framework, the paper adds empirical nuance and conceptual clarity to the notion of 'throughput legitimacy' and its components: openness, inclusiveness, transparency and accountability. Detailed case studie…

Real-Time Localization of Epileptogenic Foci EEG Signals: An FPGA-Based Implementation

2020

The epileptogenic focus is a brain area that may be surgically removed to control of epileptic seizures. Locating it is an essential and crucial step prior to the surgical treatment. However, given the difficulty of determining the localization of this brain region responsible of the initial seizure discharge, many works have proposed machine learning methods for the automatic classification of focal and non-focal electroencephalographic (EEG) signals. These works use automatic classification as an analysis tool for helping neurosurgeons to identify focal areas off-line, out of surgery, during the processing of the huge amount of information collected during several days of patient monitori…

Field-induced nanolithography for high-throughput pattern transfer.

2009

A novel frequency reuse scheme for coordinated multi-point transmission

2010

La transmisión multipunto coordinada (CoMP) se considera en 3GPP LTE-Advanced como una técnica clave para mejorar el rendimiento en el borde de la célula. Con el fin de apoyar la asignación conjunta de asignación de recursos entre células coordinadas en sistemas CoMP, es necesario diseñar esquemas eficientes de reutilización de frecuencias. Sin embargo, la mayoría de los esquemas de reutilización de frecuencias existentes no son adecuados para transmisión CoMP debido a que no consideran el escenario de transmisión conjunta multicelular en su regla de reutilización de frecuencias. Para resolver este problema, en este trabajo se propone un esquema de reutilización de frecuencias que divide el…

Digital techniques for high-rate high-resolution radiation measurements

2014

Digital pulse processing (DPP) techniques are increasingly used in the development of modern spectroscopic systems. DPP systems, based on direct digitizing and processing of detector signals (preamplifier output signals), ensure higher flexibility, stability, lower dead time, higher throughput and better energy resolution than traditional pulse processing systems. In this work, we present our progress in the development of DPP systems for high-rate high-resolution radiation measurements. An innovative digital system, able to perform multi-parameter analysis (input counting rate, pulse height, pulse shape, event arrival time, etc.) even at high photon counting rates is presented. Experimenta…

Developments Around the Activity-Based Costing Method: A State-of-the Art Literature Review

2007

This paper analyzes the management accounting applications which try to improve the Activity-based Costing method. In the first part, we describe them using the Strategic Management Accounting stream. Then, we present the main features of these applications. In the second part, we examine in detail two of these features: The widening of the analysis perimeter and the relevant level of details to analyze the costs. Finally, we analyze several proposals: Customer-driven ABC, Inter-organizational Cost Management, Resource Consumption Accounting and Time-driven ABC.

Aggregated Packet Transmission in Duty-Cycled WSNs: Modeling and Performance Evaluation

2017

[EN] Duty cycling (DC) is a popular technique for energy conservation in wireless sensor networks (WSNs) that allows nodes to wake up and sleep periodically. Typically, a single-packet transmission (SPT) occurs per cycle, leading to possibly long delay. With aggregated packet transmission (APT), nodes transmit a batch of packets in a single cycle. The potential benefits brought by an APT scheme include shorter delay, higher throughput, and higher energy efficiency. In the literature, different analytical models have been proposed to evaluate the performance of SPT schemes. However, no analytical models for the APT mode on synchronous DC medium access control (MAC) mechanisms exist. In this …

Cost Analysis of FMS Throughput

1988

Abstract The need for an effective cost planning and control system is stressed in today highly competitive manufacturing environment. The conventional approaches of machining economics to cost analysis are no more able to cope with the new structure of the production costs in the highly automated - highly integrated manufacturing systems. Suitable cost analysis procedures should provide a strong integration between process planning data and overall system performances. The here proposed procedure for the estimate of the unit manufacturing cost in FMSs achieves this integration by using performance evaluation techniques like discrete event simulation or queueing network models.

Insight on bacteria communities in outdoor bronze and marble artefacts in a changing environment

2022

Epilithic bacteria play a fundamental role in the conservation of cultural heritage (CH) materials. On stones, bacterial communities cause both degradation and bioprotection actions. Bronze biocorrosion in non-burial conditions is rarely studied. Only few studies have examined the relationship between bacteria communities and the chemical composi- tion of patinas (surface degradation layers). A better comprehension of bacterial communities growing on our CH is fundamental not only to understand the related decay mechanisms but also to foresee possible shifts in their compo- sition due to climate change. The present study aims at (1) characterizing bacterial communities on bronze andmarble s…