Search results for "throughput"
showing 10 items of 483 documents
Human computer interactive future framework: automation of human interaction and interfaces
2020
Contemporary era technological improvements and social living urges the advancement of technological implementations and to create an environment for automation of interaction platform. The sole aim being the reduction of labour work or human effort and optimising the throughput gained. The future generation is expecting such developments in current systems, but none can elucidate the particular area of improvements to be done for future models. In order to cater such requirements, a HCI future framework for automating the interaction and interfaces is proposed. The framework is divided into ten co-frames of interfaces with further classifications for facilitating the understanding of indiv…
Demo abstract: Cross-technology TDMA synchronization using energy pattern beacons
2017
When different technologies use the same frequency bands in close proximity, the resulting interference typically results in performance degradation. Coexistence methods exist, but these are often technology specific and require technology specific interference detection methods. To remove the root cause of the performance degradation, devices should be able to negotiate medium access even when using different technologies. To this end, an architecture that allows cross-technology medium access by means of a Time Division Multiple Access (TDMA) scheme was devised. In order to achieve cross-technology synchronization, which is required for the TDMA solution, an energy pattern beacon is trans…
Phylogeny and prevalence of kobuviruses in dogs and cats in the UK
2013
AbstractThe kobuviruses represent an emerging genus in the Picornaviridae. Here we have used next generation sequencing and conventional approaches to identify the first canine kobuvirus (CaKoV) from outside the USA. Phylogenetic analysis suggests that a single lineage genotype of CaKoV now exists in Europe and the USA with 94% nucleotide similarity in the coding region. CaKoV was only identified in a single case from a case–control study of canine diarrhoea, suggesting this virus was not a frequent cause of disease in this population. Attempts to grow CaKoV in cell culture failed. Sequence analysis suggested CaKoV was distinct from human Aichi virus (AiV), and unlikely to pose a significan…
The differential diagnoses of uterine leiomyomas and leiomyosarcomas using DNA and RNA sequencing.
2019
BACKGROUND: Although uterine leiomyomas and leiomyosarcomas are considered biologically unrelated tumors, they share morphologic and histologic characteristics that complicate their differential diagnosis. The long-term therapeutic option for leiomyoma is laparoscopic myomectomy with morcellation, particularly for patients who wish to preserve their fertility. However, because of the potential dissemination of undiagnosed or hidden leiomyosarcoma from morcellation, there is a need to develop a preoperative assessment of malignancy risk. OBJECTIVE: Through an integrated comparative genomic and transcriptomic analysis, we aim to identify differential genetic targets in leiomyomas vs leiomyosa…
Molecular dynamics, dynamic site mapping, and highthroughput virtual screening on leptin and the Ob receptor as anti-obesity target.
2014
Body weight control is a mechanism finely regulated by several hormonal, metabolic, and nervous pathways. The leptin receptor (Ob-R) is crucial for energy homeostasis and regulation of food uptake. Leptin is a 16 kDa hormone that is mainly secreted by fat cells into the bloodstream, and under normal circumstances, circulating levels are proportionate to the fat body mass. Sensing of elevated leptin levels by the hypothalamic neurocircutry activates a negative feedback loop resulting in reduced food intake and increased energy expenditure. Decreased concentrations lead to opposite effects. Therefore rational design of leptin agonists constitute an appealing challenge in the battle against ob…
Transcriptomic Analyses Reveal 2 and 4 Family Members of Cytochromes P450 (CYP) Involved in LPS Inflammatory Response in Pharynx of Ciona robusta
2021
Cytochromes P450 (CYP) are enzymes responsible for the biotransformation of most endogenous and exogenous agents. The expression of each CYP is influenced by a unique combination of mechanisms and factors including genetic polymorphisms, induction by xenobiotics, and regulation by cytokines and hormones. In recent years, Ciona robusta, one of the closest living relatives of vertebrates, has become a model in various fields of biology, in particular for studying inflammatory response. Using an in vivo LPS exposure strategy, next-generation sequencing (NGS) and qRT-PCR combined with bioinformatics and in silico analyses, compared whole pharynx transcripts from naïve and LPS-exposed C. robusta…
Performance and Implementation Modeling of Gated Linear Networks on FPGA for Lossless Image Compression
2020
Over recent years, imaging systems have seen explosive increase in resolution. These trends present a challenge for resource-constrained embedded imaging devices. Efficient image compression is essential to reduce bandwidth consumption and to increase the capability of on-board storage. Especially, for imaging systems where information loss is not allowed, for example, in medical, military and remote sensing imaging systems. This paper explores the use of Gated Linear Networks (GLNs) for development of embedded lossless compression systems. GLNs have proved themselves via PAQ archiver series, that have been ranked among the top across several lossless compression benchmarks. We propose an a…
Multi-Connectivity in 5G and Beyond Non-Terrestrial Networks
2022
The Fifth Generation (5G) communications systems aim to serve such service classes as Ultra-Reliable Low Latency Communications (URLLC), enhanced Mobile Broadband (eMBB), and massive Machine-Type Communications (mMTC). To meet the growing requirements posed to mobile networks, satellites can be used to complement the Terrestrial Networks (TNs). To increase the efficiency of the satellite communications involved, bandwidth-efficient techniques should be used. Multi- Connectivity (MC) is one such technique. In MC, a User Equipment (UE), for example, a smartphone, can be connected to multiple Next Generation Node Bs (gNBs) simultaneously. In this paper, an adaptive MC activation scheme for thr…
Expression inactivation of SMARCA4 by microRNAs in lung tumors
2014
SMARCA4 is the catalytic subunit of the SWI/SNF chromatin-remodeling complex, which alters the interactions between DNA and histones and modifies the availability of the DNA for transcription. The latest deep sequencing of tumor genomes has reinforced the important and ubiquitous tumor suppressor role of the SWI/SNF complex in cancer. However, although SWI/SNF complex plays a key role in gene expression, the regulation of this complex itself is poorly understood. Significantly, an understanding of the regulation of SMARCA4 expression has gained in importance due to recent proposals incorporating it in therapeutic strategies that use synthetic lethal interactions between SMARCA4-MAX and SMAR…
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use…
2013
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. Hepatotoxicity, as well as hepatic metabolism, is controlled by a set of nuclear receptors (including PXR, CAR, HNF-4α, FXR, LXR, SHP, VDR and PPAR) and signaling pathways. When isolating liver cells, some pathways are activated, e.g., the RAS/MEK/ERK pathway, whereas others are silenced (e.g. HNF-4α), resulting in…