Search results for "throughput"

Amplicon-based high-throughput pooled sequencing identifies mutations in CYP7B1 and SPG7 in sporadic spastic paraplegia patients

2011

Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder defined clinically by progressive lower limb spasticity and weakness. HSP is a genetically highly heterogeneous condition with at least 46 gene loci identified so far, involving X-linked, autosomal recessive (AR) and autosomal dominant inheritance. For correct diagnosis, molecular testing is essential because clinical parameters by themselves are not reliable to differentiate HSP forms. The purpose of this study was to establish amplicon-based high-throughput genotyping for AR-HSP. A sample of 187 index cases with apparently sporadic or recessive spastic paraplegia were analyzed by applying an array-based amplification stra…

Biofiltration of airborne VOCs with green wall systems : microbial and chemical dynamics

2018

Botanical air filtration is a promising technology for reducing indoor air contaminants, but the underlying mechanisms need better understanding. Here, we made a set of chamber fumigation experiments of up to 16 weeks of duration, to study the filtration efficiencies for seven volatile organic compounds (VOCs; decane, toluene, 2‐ethylhexanol, α‐pinene, octane, benzene, and xylene) and to monitor microbial dynamics in simulated green wall systems. Biofiltration functioned on sub‐ppm VOC levels without concentration‐dependence. Airflow through the growth medium was needed for efficient removal of chemically diverse VOCs, and the use of optimized commercial growth medium further improved the e…

Myotonic dystrophy: candidate small molecule therapeutics

2017

Myotonic dystrophy type 1 (DM1) is a rare multisystemic neuromuscular disorder caused by expansion of CTG trinucleotide repeats in the noncoding region of the DMPK gene. Mutant DMPK transcripts are toxic and alter gene expression at several levels. Chiefly, the secondary structure formed by CUGs has a strong propensity to capture and retain proteins, like those of the muscleblind-like (MBNL) family. Sequestered MBNL proteins cannot then fulfill their normal functions. Many therapeutic approaches have been explored to reverse these pathological consequences. Here, we review the myriad of small molecules that have been proposed for DM1, including examples obtained from computational rational …

Generazione di una banca di peptidi plasmatici. Applicazione di una strategia High-throughput screening per l’analisi della loro interazione con il s…

2012

Analysis of MAC-level throughput in LTE systems with link rate adaptation and HARQ protocols

2015

LTE is rapidly gaining momentum for building future 4G cellular systems, and real operational networks are under deployment worldwide. To achieve high throughput performance, in addition to an advanced physical layer design LTE exploits a combination of sophisticated mechanisms at the radio resource management layer. Clearly, this makes difficult to develop analytical tools to accurately assess and optimise the user perceived throughput under realistic channel assumptions. Thus, most existing studies focus only on link-layer throughput or consider individual mechanisms in isolation. The main contribution of this paper is a unified modelling framework of the MAC-level downlink throughput of …

Characterization of IP-Based Communication for Smart Grid Using Software-Defined Networking

2018

The smart grid (SG) approach is based on a strong interaction between the network communication infrastructure and the power grid. Usually the management of the infrastructure is done by the distribution system operators (DSOs) that are worried about the increasing managing complexity due to the presence of increasing number of distributed energy resources and electrical vehicles. The use of software-defined networking (SDN) may simplify the network configuration and management for DSO, as highlighted from previous research works. The objective of this paper is to introduce and characterize an internet protocol (IP)-based communication architecture with specialized SDN bridges operating als…

Voice traffic bicasting enhancements in mobile HSPA network

2014

This paper discusses methods for improving the effectiveness of delivering voice traffic over High-Speed Downlink Packet Access (HSDPA) network by employing transmission diversity with Single-Frequency Dual-Cell (SF-DC) Aggregation that is part of the Multiflow specification. SF-DC Aggregation allows the user to be served at the same time by two different cells. The enhancements discussed in the paper capitalize strongly on the availability of the composed Channel Quality Indication (CQI) feedback at both serving cells. According to the results obtained from the network simulations, the ability to select the better channel for each voice transmission significantly decreases the required tra…

BioImageXD: an open, general-purpose and high-throughput image-processing platform

2012

BioImageXD puts open-source computer science tools for three-dimensional visualization and analysis into the hands of all researchers, through a user-friendly graphical interface tuned to the needs of biologists. BioImageXD has no restrictive licenses or undisclosed algorithms and enables publication of precise, reproducible and modifiable workflows. It allows simple construction of processing pipelines and should enable biologists to perform challenging analyses of complex processes. We demonstrate its performance in a study of integrin clustering in response to selected inhibitors.

Towards Mitigating the Impact of UAVs on Cellular Communications

2018

The next generation of Unmanned Aerial Vehicles (UAVs) will rely on mobile networks as a communication infrastructure. Several issues need to be addressed to enable the expected potentials from this communication. In particular, it was demonstrated that flying UAVs perceive a high number of base stations (BSs), consequently causing more interferences on non-serving BSs. This unfortunately results in decreased throughput for ground user equipments (UEs) already connected. Such a problem could be a limiting factor for mobile network-enabled UAVs, due to its consequences on the quality of experience (QoE) of served UEs. This underpins the focus of this article, wherein the effect of UAVs' comm…

On the effects of transmit power control on the energy consumption of WiFi network cards

2009

Transmit power control has been largely proposed as a solution to improve the performance of packet radio systems in terms of increased throughput, spatial reuse and battery lifetime for mobile terminals. However, the benefits of transmit power control schemes on these different performance figures may strongly depend on the employed PHY technology and channel access mechanism. In this paper, we focus on the effects of power control on the energy consumption of WiFi network cards. By means of several experimental tests carried out under different operation conditions and modulation schemes, we try to justify why the reduction of the transmission power has a marginal effect on the overall en…