Search results for "thyroid carcinoma"

showing 10 items of 69 documents

Cancer of the Thyroid

2021

Thyroid cancers are the most frequent endocrine neoplasms whose incidence is globally increasing. Thyroid carcinomas basically derived from follicular (papillary, follicular, anaplastic and poorly differentiated) or parafollicular cells (medullary). The diagnostic evaluation of thyroid cancers is mainly based on neck ultrasonography along with fine needle aspiration. First initial risk evaluation should be carried out postoperatively, while a dynamic risk stratification should be continually assessed to personalize treatment. Whereas combination of surgery, adjuvant radioactive iodine (RAI) ablation, and hormone therapy enables high rates of cure in differentiated tumors (DTC), surgical res…

OncologySorafenibmedicine.medical_specialtyCabozantinibbusiness.industrySettore MED/06 - Oncologia MedicaThyroidVandetanibmedicine.diseaseSettore MED/13 - EndocrinologiaThyroid carcinomaThyroid cancer classification diagnosischemistry.chemical_compoundmedicine.anatomical_structurechemistryInternal medicineEndocrine neoplasmmedicineSettore MED/49 - Scienze Tecniche Dietetiche ApplicateLenvatinibbusinessThyroid cancermedicine.drug
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Breast cancer in previously thyroidectomized patients: which thyroid disorders are a risk factor?

2021

The aim of this study was to evaluate whether there are thyroid diseases in which breast cancer will appear later as well as the role of autoimmunity. This was a retrospective observational study. A total of 410 females (thyroid surgery and later breast cancer) and 524 females (thyroid surgery only) were compared with regard to pathological thyroid findings, thyroid hormones, thyroid autoimmunity and type of breast cancer. Thyroid autoimmunity, especially antithyroid peroxidase antibodies, significantly increased the risk of breast cancer (p < 0.01); however, this was not true for other thyroid diseases, including thyroid cancer. No variant of breast cancer was predominant, and only thyroid…

Oncologymedicine.medical_specialtyendocrine systemendocrine system diseases030209 endocrinology & metabolismmedicine.disease_causeAutoimmunityThyroid carcinomaClinical Trial Evaluation03 medical and health sciences0302 clinical medicineBreast cancerbreast cancerInternal medicinethyroid dysfunctionsmedicineRisk factorskin and connective tissue diseasesbusiness.industryThyroidRetrospective cohort studymedicine.diseasethyroid autoantibodiesthyroid carcinomaAnti-thyroid autoantibodiesthyroid disordersmedicine.anatomical_structure030220 oncology & carcinogenesisthyroid autoimmunityThyroid autoimmunitybusinessBiotechnologyFuture Science OA
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PTC REFRACTORY TO RADIOIODINE: A CROSS-SECTIONAL STUDY

2015

Papillary Thyroid Carcinoma
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The coexistence of primary hyperparathyroidism and thyroid nodules: Should the preoperative work-up of the parathyroid and the thyroid diseases be sp…

2016

Introduction and objectives. Primary hyperparathyroidism (PHPT) can be found in concomitance with thyroid disease (TD) in a high frequency of cases. In this context the diagnostic exams for localizing the enlarged parathyroid(s) gland(s) could be less reliable or nonconclusive. Moreover, the thyroid carcinoma seems to be more frequent compared to that isolated thyroid desease and, therefore, carefully investigated. The main goal of the present study is to evaluate which diagnostic tool (US, MIBI) is more reliable for localizing the site of the PTH hypersecretion and to confirm if it is always advantageous a combination of both exams. Besides, we evaluated the incidence of thyroid carcinoma …

ParathyroidectomyThyroid nodulesAdultMalemedicine.medical_specialtymedicine.medical_treatmentPrimary hyperparathyroidismPreoperative careClinical PracticeThyroid carcinoma03 medical and health sciences0302 clinical medicineRetrospective StudiePreoperative CareHumansMedicineMIBIThyroid NoduleRetrospective StudiesAgedAged 80 and overbusiness.industryThyroid diseaseThyroidThyroidectomyMiddle Agedmedicine.diseaseThyroid diseaseHyperparathyroidism Primarymedicine.anatomical_structure030220 oncology & carcinogenesisThyroidectomy030211 gastroenterology & hepatologyFemaleRadiologybusinessPrimary hyperparathyroidismHuman
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In Vitro Identification and Characterization of CD133pos Cancer Stem-Like Cells in Anaplastic Thyroid Carcinoma Cell Lines

2008

BackgroundRecent publications suggest that neoplastic initiation and growth are dependent on a small subset of cells, termed cancer stem cells (CSCs). Anaplastic Thyroid Carcinoma (ATC) is a very aggressive solid tumor with poor prognosis, characterized by high dedifferentiation. The existence of CSCs might account for the heterogeneity of ATC lesions. CD133 has been identified as a stem cell marker for normal and cancerous tissues, although its biological function remains unknown.Methodology/principal findingsATC cell lines ARO, KAT-4, KAT-18 and FRO were analyzed for CD133 expression. Flow cytometry showed CD133(pos) cells only in ARO and KAT-4 (64+/-9% and 57+/-12%, respectively). These …

Pathologymedicine.medical_specialtySciencemedicine.medical_treatmentThyroid Nuclear Factor 1Cell Culture TechniquesAntineoplastic AgentsCell SeparationStem cell markerDiabetes and Endocrinology/ThyroidSettore MED/13 - EndocrinologiaAntigens CDThyroid peroxidaseCancer stem cellCell Line TumorBiomarkers TumormedicineHumansANAPLASTIC THYROID CARCINOMA CANCER STEM CELLS CD133AC133 AntigenThyroid NeoplasmsGenetics and Genomics/Cancer GeneticsThyroid cancerTumor Stem Cell AssayCell ProliferationGlycoproteinsOncology/Head and Neck CancersMultidisciplinarybiologyCell growthQCarcinomaRNuclear ProteinsTumor Stem Cell Assaymedicine.diseaseFibronectinsembryonic structuresNeoplastic Stem CellsCancer researchbiology.proteinMedicineThyroglobulinStem cellPeptidesTranscription FactorsResearch ArticlePLoS ONE
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Differential Gene Expression of Medullary Thyroid Carcinoma Reveals Specific Markers Associated with Genetic Conditions

2013

Maliszewska, Agnieszka et al.

Pathologymedicine.medical_specialtyendocrine system diseasesInheritance PatternsMultiple endocrine neoplasia type 2ApoptosisBiologyGermlinePathology and Forensic MedicineThyroid carcinomaAntigens CDCell Line TumormedicineBiomarkers TumorGene silencingCluster AnalysisHumansGenetic Predisposition to DiseaseAC133 AntigenGene SilencingThyroid NeoplasmsRNA Small InterferingGlycoproteinsRegulation of gene expressionTissue microarrayReverse Transcriptase Polymerase Chain ReactionGene Expression ProfilingWnt signaling pathwaymedicine.diseaseImmunohistochemistryCarcinoma NeuroendocrineGene expression profilingGene Expression Regulation NeoplasticGene Knockdown TechniquesCancer researchPeptides
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Medullary Thyroid Carcinoma With Exon 2 p.L56M RET Variant: Clinical Particular Features in Two Patients

2018

RET (REarranged during Transfection) proto-oncogene variants are essential for the development of familial and sporadic forms of medullary thyroid carcinoma (MTC). The most frequent variants are usually located in exons 10, 11, and 13 through 16 of the RET gene. We report two cases of apparently sporadic MTC associated with the variant in exon 2 of RET gene. Patient 1, a 62-year old man who had undergone adrenalectomy for a 5 cm pheochromocytoma, was screened for type 2 multiple endocrine neoplasia (MEN 2) which showed elevated basal and post-intravenous calcium gluconate calcitonin levels. A fine needle aspiration biopsy (FNAB) confirmed the suspicion of MTC. The patient underwent total th…

Pathologymedicine.medical_specialtyendocrine systemMedullary cavityendocrine system diseasesEndocrinology Diabetes and Metabolism030209 endocrinology & metabolismCase ReportL56M; Medullary thyroid carcinoma; MEN2; Pheochromocytoma; RET; Endocrinology Diabetes and Metabolismlcsh:Diseases of the endocrine glands. Clinical endocrinologyThyroid carcinomaPheochromocytoma03 medical and health sciences0302 clinical medicineEndocrinologymedullary thyroid carcinomaBiopsymedicineMultiple endocrine neoplasialcsh:RC648-665medicine.diagnostic_testbusiness.industrySettore MED/13 - ENDOCRINOLOGIAHyperplasiamedicine.diseasepheochromocytomaDiabetes and MetabolismFine-needle aspirationMEN2Calcitonin030220 oncology & carcinogenesisbusinessRETL56MFrontiers in Endocrinology
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Multiple Pluripotent Stem Cell Markers in Human Anaplastic Thyroid Cancer: The Putative Upstream Role of SOX2

2013

Anaplastic thyroid carcinoma (ATC) is a rare and aggressive endocrine tumor with highly undifferentiated morphology. It has been suggested that cancer stem cells (CSCs) might play a central role in ATC. The objectives of this study were (i) to characterize CSCs from ex vivo ATC specimens by investigating the expression of several pluripotent stem cell markers, and (ii) to evaluate in vitro drug resistance modifications after specific CSC transcription factor switch-off.In ex vivo experiments, eight formalin-fixed, paraffin-embedded ATC specimens were analyzed by reverse-transcription and real-time quantitative PCR and immunohistochemistry. In in vitro experiments using ATC SW1736 cells, the…

Pluripotent Stem Cellscongenital hereditary and neonatal diseases and abnormalitiesEndocrinology Diabetes and MetabolismDown-RegulationBiologyThyroid Carcinoma AnaplasticAnaplastic thyroid cancer cancer stem cell SOX-2Settore MED/13 - EndocrinologiaThyroid carcinomaKruppel-Like Factor 4EndocrinologySOX2Cancer stem cellCell Line TumormedicineATP Binding Cassette Transporter Subfamily G Member 2HumansNeoplasmThyroid NeoplasmsAnaplastic thyroid cancerInduced pluripotent stem cellHomeodomain ProteinsSOXB1 Transcription FactorsNanog Homeobox ProteinNanog Homeobox ProteinThyroid Cancer and Nodulesmedicine.diseaseNeoplasm ProteinsUp-RegulationDoxorubicinDrug Resistance NeoplasmCell cultureNeoplastic Stem CellsCancer researchATP-Binding Cassette TransportersCisplatinOctamer Transcription Factor-3Thyroid
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Differential proteomic and phenotypic behaviour of papillary and anaplastic thyroid cell lines.

2013

Abstract Thyroid carcinomas account for a minority of all malignant tumours but, after those of the gonads, they represent the most common forms of endocrine cancers. They include several types, among which the papillary thyroid cancer (PTC) and the anaplastic thyroid cancer (ATC) are the best known. The two hystotypes display significant biological and clinical differences: PTC is a well differentiated form of tumour with a high incidence and a good prognosis, while the ATC is less frequent but represents one of the most aggressive endocrine tumours with morphological features of an undifferentiated type. To date, as far as we know, no conclusive studies, useful to design arrays of molecul…

ProteomicsProteomeendocrine system diseasesProtein Array AnalysisBiophysicsBiologythyroid cell linesThyroid Carcinoma AnaplasticProteomicsBiochemistryPapillary thyroid cancerThyroid carcinomaCell MovementCell Line TumorBiomarkers TumormedicineHumansEndocrine systemThyroid NeoplasmsAnaplastic thyroid cancerThyroid cancerCell ProliferationCarcinomamedicine.diseasePhenotypeCarcinoma PapillaryNeoplasm ProteinsThyroid Cancer PapillaryImmunologyProteomeCancer research
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Role of PTPRJ genotype in papillary thyroid carcinoma risk

2010

The strong genetic predisposition to papillary thyroid carcinoma (PTC) might be due to a combination of low-penetrance susceptibility variants. Thus, the research into gene variants involved in the increase of susceptibility to PTC is a relevant field of investigation. The gene coding for the receptor-type tyrosine phosphatase PTPRJ has been proposed as a cancer susceptibility gene, and its role as a tumor suppressor gene is well established in thyroid carcinogenesis. In this study, we want to ascertain the role of PTPRJ genotype in the risk for PTC. We performed a case–control study in which we determined the PTPRJ genotype for the non-synonymous Gln276Pro and Asp872Glu polymorphisms by PC…

RiskOncologyCancer Researchmedicine.medical_specialtyGenotypeendocrine system diseasesEndocrinology Diabetes and MetabolismBiologyPolymerase Chain ReactionArticleSettore MED/13 - EndocrinologiaThyroid carcinomaEndocrinologyGene FrequencyInternal medicineGenotypeOdds RatiomedicineGenetic predispositionHumansGenetic Predisposition to DiseaseThyroid NeoplasmsAlleleAllele frequencyAllelesGenetic Association StudiesPapillay thyroid carcinomaGeneticsChi-Square DistributionPolymorphism GeneticReceptor-Like Protein Tyrosine Phosphatases Class 3ThyroidCase-control studyCarcinoma PapillaryGenotype frequencymedicine.anatomical_structureOncologyCase-Control Studies
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