6533b860fe1ef96bd12c3c28
RESEARCH PRODUCT
Breast cancer in previously thyroidectomized patients: which thyroid disorders are a risk factor?
G. MelfaGabriella MilitelloBrenda RandisiGiuseppina OrlandoGiuseppa GraceffaGregorio ScerrinoCalogero CipollaIole LaiseGianfranco CocorulloS Mazzolasubject
Oncologymedicine.medical_specialtyendocrine systemendocrine system diseases030209 endocrinology & metabolismmedicine.disease_causeAutoimmunityThyroid carcinomaClinical Trial Evaluation03 medical and health sciences0302 clinical medicineBreast cancerbreast cancerInternal medicinethyroid dysfunctionsmedicineRisk factorskin and connective tissue diseasesbusiness.industryThyroidRetrospective cohort studymedicine.diseasethyroid autoantibodiesthyroid carcinomaAnti-thyroid autoantibodiesthyroid disordersmedicine.anatomical_structure030220 oncology & carcinogenesisthyroid autoimmunityThyroid autoimmunitybusinessBiotechnologydescription
The aim of this study was to evaluate whether there are thyroid diseases in which breast cancer will appear later as well as the role of autoimmunity. This was a retrospective observational study. A total of 410 females (thyroid surgery and later breast cancer) and 524 females (thyroid surgery only) were compared with regard to pathological thyroid findings, thyroid hormones, thyroid autoimmunity and type of breast cancer. Thyroid autoimmunity, especially antithyroid peroxidase antibodies, significantly increased the risk of breast cancer (p < 0.01); however, this was not true for other thyroid diseases, including thyroid cancer. No variant of breast cancer was predominant, and only thyroid autoimmunity was associated with the risk of breast cancer. Further research is needed to explain the impacts of different antithyroid antibodies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-03-01 | Future Science OA |