Search results for "tipo"
showing 10 items of 704 documents
Chloride, carboxylate and carbonate transport by ortho-phenylenediamine-based bisureas
2013
Highly potent but structurally simple transmembrane anion transporters are reported that function at receptor to lipid ratios as low as 1 : 1 000 000. The compounds, based on the simple ortho-phenylenediamine-based bisurea scaffold, have been studied for their ability to facilitate chloride/nitrate and chloride/bicarbonate antiport, and HCl symport processes using a combination of ion selective electrode and fluorescence techniques. In addition, the transmembrane transport of dicarboxylate anions (maleate and fumarate) by the compounds was examined. Molecular dynamics simulations showed that these compounds permeate the membrane more easily than other promising receptors corroborating the e…
Epigenetic modifiers are necessary but not sufficient for reprogramming non-myelinating cells into myelin gene-expressing cells.
2010
Background Modifications on specific histone residues and DNA methylation play an essential role in lineage choice and cellular reprogramming. We have previously shown that histone modifications or combinatorial codes of transcription factors (TFs) are critical for the differentiation of multipotential progenitors into myelinating oligodendrocytes. In this study we asked whether combining global manipulation of DNA methylation and histone acetylation together with the expression of oligodendrocyte- specific TFs, was sufficient to switch the identity of fibroblasts into myelin gene-expressing cells. Methodology/Principal Findings Transfection of six oligodendrocyte-specific TFs (Olig1, Olig2…
Centrosome structure is very similar in eupyrene and apyrene spermatocytes ofEphestia kuehniella(Pyralidae, Lepidoptera, Insecta)
1997
Summary The higher Lepidoptera produce two types of sperm, eupyrene and apyrene. Eupyrene spermatozoa are fertile, while apyrene spermatozoa are anucleate and, therefore, sterile. Meiosis differs between the two developmental lines. One of the most obvious differences is the aberrant organization of the apyrene spindles. They possess fewer microtubules than eupyrene spindles and chromosome segregation is irregular. To determine whether micotubule nucleation is impaired in the aprene spindles, the present fine structure study concentrated on the centrosomes in both spermatocyte types. In addition, the presence of gamma-tubulin, a newly discovered tubulin isoform which is prevalent in centros…
Análisis coste-utilidad de la triple terapia con telaprevir en pacientes con hepatitis C no tratados previamente
2014
Introducción: En España, con una prevalencia del 2,5%, la hepatitis C (VHC) se asocia a una elevada morbi-mortalidad. El tratamiento combinado de telaprevir y peginterferon/ribavirina ([T/PR]) es eficaz en pacientes con VHC-G1. El objetivo primario de este estudio fue evaluar la relación coste-utilidad (RCUI) de [T/PR] versus peginterferon alfa 2a/ribavirina ([PR]) en pacientes naïve VHC-G1, según el grado de fibrosis y bajo la perspectiva del sistema sanitario español. Metodología: La eficacia y la incidencia de efectos adversos (EAs) se obtuvieron de los estudios ADVANCE y OPTIMIZE. La estimación de los costes de monitorización, de manejo de EAs y de la enfermedad por estados de salud (,…
Tipogrāfs Gerhards Šrēders un latīņu okazionālā dzeja
2019
Rakstā atainota Rīgas pilsētas otrā tipogrāfa Gerharda Šrēdera (Gerhard Schröder, ?-1657) darbības vide un dzīvesgājums. Vispirms iezīmēti grāmatiespiešanas pirmsākumi Rīgā, tipogrāfa pienākumi, pasūtījumu klāsts, atlīdzība par darbu un iegūstamās privilēģijas. Tad aplūkoti priekšnoteikumi, kas Gerhardam Šrēderam bija jāizpilda, lai iegūtu Rātes atļauju pārņemt darbu Nikolaja Mollīna (Niclaes Mollijns, ap 1550/1555-1625) spiestuvē. Tipogrāfijas kvalitātes un iespieddarbu specifikas raksturošanai pētīti okazionālās dzejas iespieddarbi: apskatīts poligrāfiskais izpildījums (vienā iespieddarbā izmantoto dažādo izmēru un veidu burtu komplektu skaits, dekoratīvo elementu, kokgrebumu un gravīru p…
Predictive Role of Caregiver Type, Dependency Level and Time Caring on the Impact of Caring for a Dependent Relative as a Stressor
2014
This work presents the evaluation of the stress symptoms associated to the task of caring for a dependent relative at home. The role played by variables such as type of caregiver (nurse/non-nurse), the relative dependency level, the number of hours per day dedicated to caring and the years the caregiver had been caring for the relative was studied. The sample was made up of 100 caregivers, and the variables associated to stress studied in the present work were intrusion, avoidance and activation. Results showed that non-nurse caregivers caring for a low dependency relative for a period of less than two years were those suffering a higher impact, with more symptoms associated to stress. Hour…
DcuA of aerobically grownEscherichia coliserves as a nitrogen shuttle (L‐aspartate/fumarate) for nitrogen uptake
2018
DcuA of Escherichia coli is known as an alternative C4 -dicarboxylate transporter for the main anaerobic C4 -dicarboxylate transporter DcuB. Since dcuA is expressed constitutively under aerobic and anaerobic conditions, DcuA was suggested to serve aerobically as a backup for the aerobic (DctA) transporter, or for the anabolic uptake of C4 -dicarboxylates. In this work, it is shown that DcuA is required for aerobic growth with L-aspartate as a nitrogen source, whereas for growth with L-aspartate as a carbon source, DctA was needed. Strains with DcuA catalyzed L-aspartate and C4 -dicarboxylate uptake (like DctA), or an L-aspartate/C4 -dicarboxylate antiport (unlike DctA). DcuA preferred L-asp…
Nuova galassia tipografico-digitale
2007
Nell’era digitale nella quale viviamo, che la grafica sia “fuori delle regole” è una constatazione ormai pacifica e condivisa. Con l’avvento del (personal) computer, negli anni ottanta, si determina infatti un momento cruciale nella storia della comunicazione visiva (il Mac è del 1984). Il computer imprime un drastico rinnovamento delle tecniche operative, accelerando il processo (già in corso) da un metodo di progetto essenzialmente razionale a modalità di comunicazione sempre più impattanti, e sempre meno ancorate alle regole.
Can bone marrow-derived multipotent adult progenitor cells regenerate infarcted myocardium?
2006
Objectives: To assess the functional effects of multipotent adult progenitor cells (MAPCs) transplanted in a rat model of chronic myocardial infarction. Methods: Forty-four rats underwent coronary ligation and, 14 days later, were randomly allocated to receive in-scar injections (5×106 cells/150 μL) of green fluorescent protein (eGFP)-transduced allogeneic MAPCs ( n =25) or culture medium (controls, n =19). Nine of the MAPC-treated hearts were employed for functional studies while the remaining 16 received cells co-labeled with Resovist™ and were only used for serial histological assessments. Left ventricular (LV) function was assessed echocardiographically before transplantation and 1 mont…
Letras de cine : tipografía queer para formar a docentes en diversidad y cultura visual
2021
En este trabajo presentamos una serie de propuestas para innovar en el ámbito de la formación de docentes desde una perspectiva crítica. Basándonos en el arte y el diseño incorporamos aspectos creativos que van desde los discursos textuales de la cultura visual (cine) o el diseño (tipografías) hasta cuestiones de diversidad sexual y disidencias queer. Impulsamos experiencias creativas introduciendo como elemento de referencia el estudio de las tipografías diseñadas para películas de temática LGTB. Revisamos la tradición tipográfica de los elementos gráficos vinculados al cine como los carteles o las cabeceras de películas. Abordamos cuestiones transversales desde una óptica multidisciplinar…